Skin Findings in Cystic Fibrosis Cases

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dc.contributor.authorDaye, Munise
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorMevlitoglu, Inci
dc.date.accessioned2024-02-23T14:41:03Z
dc.date.available2024-02-23T14:41:03Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND/AIMS Clinical trials investigating skin findings of cystic fibrosis are limited. The aim of the present study was to evaluate the dermatological findings of patients with cystic fibrosis. MATERIAL and METHODS Twenty-six patients diagnosed with cystic fibrosis by the Department of Pediatric Chest Diseases were included in the study. In the pediatric chest diseases outpatient clinic, full blood, vitamin D, vitamin E, albumin, and IgE tests were recorded. In addition to the routine dermatological examination required from the pediatric chest diseases polyclinic, a diagnosis of aquagenic wrinkling was made. The cases were contacted with water at at 39 degrees-40 degrees C in 27 degrees C room temperature conditions, and the water-related wrinkle was assessed after 3 and 5 min of contact. RESULTS There were 12 male and 14 female cases. The average age of the patients was 78.80 (8-192) months, and the mean disease duration was 52.53 (2-180) months. In the dermatological examination of the cases, xerosis cutis (18 cases, 69.2%) was most frequently found. Aquagenic palmar wrinkles were observed in 20 (76.9%) cases, and palmar wrinkles were >30% at 5 min. In 5 (25%) cases, delta F508 mutation was present. In 7 (26.9%) cases, pili annulati was observed by light microcopy. CONCLUSION The most common skin finding in cystic fibrosis cases is xerosis. The percentage of aquagenic wrinkling is 76.9%. To our knowledge, the association of cystic fibrosis with pili annulation is a previously unreported finding and was reported for the first time in our study.en_US
dc.identifier.doi10.5152/cjms.2018.596
dc.identifier.endpage153en_US
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue3en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.5152/cjms.2018.596
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16685
dc.identifier.volume3en_US
dc.identifier.wosWOS:000459392500005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofCyprus Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCystic Fibrosisen_US
dc.subjectDermatologic Findingsen_US
dc.subjectPili Annulatien_US
dc.subjectAquagenic Palmar Wrinkleen_US
dc.titleSkin Findings in Cystic Fibrosis Casesen_US
dc.typeArticleen_US

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