Determining Stable Structure and in Vitro Antiproliferative Properties of a Novel 3-(2-((4-Trifluoromethyl)phenyl)amino)thiazol-4-yl)-2H-chromen-2-one Molecule

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dc.contributor.authorSariguney, Ahmet Burak
dc.contributor.authorSarikaya, Ebru Karakas
dc.contributor.authorPehlivanoglu, Suray
dc.date.accessioned2024-02-23T11:26:16Z
dc.date.available2024-02-23T11:26:16Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractSince coumarin and thiazole derivatives are known to have antioxidant properties, a novel derivative was synthesized in this article. 3-(2-((4-(trifluoromethyl)phenyl)amino)thiazol-4-yl)-2H-chromen-2-one (ATC) was synthesized as a novel compound with high yield and characterized by Raman, FT-IR, C-13-NMR, and H-1-NMR spectroscopic procedures and DFT calculations. In this study, the potential in vitro antiproliferative properties of the ATC compound were evaluated on colorectal cancer (HT29) and melanoma (SK-MEL-30) cell lines. According to the results, the compound was found to be significantly active, approximately 2.6-fold, against melanoma cells compared to healthy fibroblast (L929) cells. Unlike melanoma cells, the compound did not have any adverse effects on colorectal cancer cells. Due to these findings, the compound can be harnessed as a promising antiproliferative drug candidate for preclinical studies against melanoma.en_US
dc.identifier.doi10.1002/cbdv.202301216
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.pmid37870095en_US
dc.identifier.scopus2-s2.0-85180638208en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202301216
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10540
dc.identifier.wosWOS:001133657000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Canceren_US
dc.subjectDft Calculationsen_US
dc.subjectIn Vitroen_US
dc.subjectThiazole-Coumarinen_US
dc.subjectFtiren_US
dc.titleDetermining Stable Structure and in Vitro Antiproliferative Properties of a Novel 3-(2-((4-Trifluoromethyl)phenyl)amino)thiazol-4-yl)-2H-chromen-2-one Moleculeen_US
dc.typeArticleen_US

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