The Relationship Between Osteoprotegerin/RANKL Axis and Arterial Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipients

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dc.contributor.authorKocyigit, Ismail
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorDogan, Ender
dc.contributor.authorGungor, Ozkan
dc.contributor.authorOrscelik, Ozcan
dc.contributor.authorKarakukcu, Cigdem
dc.contributor.authorEroglu, Eray
dc.date.accessioned2024-02-23T14:41:25Z
dc.date.available2024-02-23T14:41:25Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: Cardiovascular diseases are the main reason of death in patients with renal transplantation (Rtx). Osteoprotegerin (OPG) is produced by osteoblasts and is linked to increased cardiovascular risk in Rtx. OPG acts as a decoy receptor binding receptor activator of nuclear factor kappa-B ligand (RANKL) and this interaction plays a role in bone resorption and vascular function. This study aimed to investigate the relation between OPG, RANKL, osteoporosis and arterial stiffness in Rtx patients. MATERIAL and METHODS: This cross-sectional study included 80 adult Rtx recipients. Femoral neck mineral density was obtained by dual-energy X-ray absorptiometry. Serum OPG and RANKL were measured by the ELISA method. Pulse-wave analysis was measured in the carotid and femoral arteries using a pulse wave velocity (PWV) machine. RESULTS: Patients were divided into two groups as normal (n:24) and osteopenia/osteoporosis group (n: 56). Body mass index was significantly lower in the osteopenic/osteoporotic group compared to the normal group. Pulse wave velocity was positively correlated with age (r:0.204,p:0.072), osteoprotegerin (r:0.219,p:0.052), calcium x phosphate product (r:0.605,p:<0.001), and systolic blood pressure (r:0.198,p:0.058) and negatively correlated with RANKL (r:-0.261,p:0.020) and creatinine clearance (r:-0.220,p:0.051). PWV was independently predicted by calcium x phosphate product but not creatinine clearance, RANKL, osteoprotegerin and systolic blood pressure. CONCLUSION: In our study, serum calcium x phosphate product but not OPG and RANKL levels were found to be the main predictor of arterial stiffness in Rtx patients.en_US
dc.identifier.doi10.5262/tndt.2015.1002.07
dc.identifier.endpage188en_US
dc.identifier.issn1300-7718
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84929725527en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2015.1002.07
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16845
dc.identifier.volume24en_US
dc.identifier.wosWOS:000374928100007en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis And Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Transplantationen_US
dc.subjectOsteoporosisen_US
dc.subjectOsteoprotegerinen_US
dc.subjectRanklen_US
dc.subjectPulse Wave Velocityen_US
dc.titleThe Relationship Between Osteoprotegerin/RANKL Axis and Arterial Stiffness in Osteopenic/Osteoporotic Renal Transplantation Recipientsen_US
dc.typeArticleen_US

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