Production of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing material

Basit Öğe Kaydı
dc.contributor.authorMutlu, Betul
dc.contributor.authorErci, Fatih
dc.contributor.authorKoc, Rabia Cakir
dc.date.accessioned2024-02-23T14:26:58Z
dc.date.available2024-02-23T14:26:58Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe incorporation of herbal extracts in wound dressing materials is an important concept that has been researched recently. In this study, alginate films incorporated in the various ratio (0.25-1% v/v) of Hypericum perforatum extract (HPE) for potential applications of wound dressing were successfully prepared by solvent-casting method. The obtained films were examined for cytotoxicity, in vitro wound healing potential, swelling behavior, antioxidant, and antibacterial properties. When compared to the alginate film (Al) alone, HPE incorporated alginate films (HPE/Al) exhibit improved antioxidant properties according to the results of CUPRAC assay and antioxidant activity increases with the rate of HPE. Also, HPE/Al films exhibited antibacterial activity against E. coli and S. aureus, and addition with the HPE extract into films significantly increased the antibacterial activity against S. aureus. All film samples had no cytotoxic effects on fibroblast cell line and HPE/Al films showed a proliferative effect with high extract concentrations (1%) compared to extract free-films. Also, scratch assay results show that films containing 0.5% (v/v) HPE may have a positive effect on wound healing. The results have shown that the newly developed HPE incorporated alginate films are a candidate as antibacterial, and antioxidant wound dressing for use on burn or excision wounds.en_US
dc.identifier.doi10.1177/08839115211073155
dc.identifier.endpage148en_US
dc.identifier.issn0883-9115
dc.identifier.issn1530-8030
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85124883943en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage134en_US
dc.identifier.urihttps://doi.org/10.1177/08839115211073155
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14396
dc.identifier.volume37en_US
dc.identifier.wosWOS:000758730300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Bioactive And Compatible Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlginateen_US
dc.subjectHypericum Perforatumen_US
dc.subjectWound Dressingen_US
dc.subjectWound Healingen_US
dc.titleProduction of alginate films containing Hypericum perforatum extract as an antibacterial and antioxidant wound dressing materialen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu