Ursodeoxycholic acid treatment for duodenogastric reflux in childhood

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dc.contributor.authorAgin, Mehmet
dc.contributor.authorGumus, Meltem
dc.contributor.authorYucel, Aylin
dc.contributor.authorYuksekkaya, Hasan Ali
dc.contributor.authorAydogdu, Sema
dc.contributor.authorTumgor, Gokhan
dc.date.accessioned2024-02-23T14:49:26Z
dc.date.available2024-02-23T14:49:26Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: The purpose of this study was to determine the clinical and histopathological features of duodenogastric reflux (DGR) in children and the effectiveness of ursodeoxycholic acid (UDCA) therapy. Design: Prospective Setting: Cukurova University Medical Faculty Pediatric Gastroenterology Clinic and Necmettin Erbakan University Medical Faculty Pediatric Gastroenterology Clinic, Adana and Konya, Turkey Subjects: One hundred and four children Intervention: One hundred and four patients with DGR were assessed in terms of their history, physical examination, endoscopy, histopathology and response to UDCA therapy. Main outcome measure: Positive results were obtained by administering UDCA treatment in addition to stomach drugs. Results: Eighty-two (79%) patients had previously used various antacids and proton pump inhibitors for dyspeptic symptoms. Gastritis was detected with upper gastrointestinal system endoscopy in all patients. Symptoms decreased by more than half or resolved completely in 97 patients (93%) at the 3-month follow-up interval. Conclusion: DGR should be considered in the etiology of patients with dyspeptic symptoms who fail to respond to antacid and proton pump inhibitor therapy. The majority of patients with DGR responded well to three months of UDCA therapy.en_US
dc.identifier.endpage245en_US
dc.identifier.issn0023-5776
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85127113667en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18182
dc.identifier.volume53en_US
dc.identifier.wosWOS:000701389600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKuwait Medical Assocen_US
dc.relation.ispartofKuwait Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectDuodenogastric Refluxen_US
dc.subjectDyspepsiaen_US
dc.subjectEndoscopyen_US
dc.subjectUrsodeoxycholic Aciden_US
dc.titleUrsodeoxycholic acid treatment for duodenogastric reflux in childhooden_US
dc.typeArticleen_US

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