Foetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitus

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dc.contributor.authorBayman, Melike Geyik
dc.contributor.authorInal, Zeynep Ozturk
dc.contributor.authorHayiroglu, Fatih
dc.contributor.authorOzturk, Elif Nur Yildirim
dc.contributor.authorGezginc, Kazim
dc.date.accessioned2024-02-23T14:17:13Z
dc.date.available2024-02-23T14:17:13Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractThe aim of our study was to investigate whether gestational diabetes mellitus (GDM) affects brain-derived neurotrophic factor (BDNF) levels in foetal umbilical cord blood. A total of 96 participants were divided into a GDM group (n = 43) and a non-diabetic control group (n = 53). Cord blood samples of approximately 5 cc were taken immediately after the foetal umbilical cord was clamped during delivery in order to determine BDNF levels. While the mean age, body mass index, birth weight, rate of caesarean delivery, rate of infant macrosomia, and neonatal intensive care unit admission of women with GDM were significantly higher compared to the non-diabetic control group (p < .05), pregnancy complications were comparable between the groups (p > .05). Although no significant differences were noted between the groups with respect to cord blood BDNF levels (0.79 +/- 0.37 ng/ml vs. 0.69 +/- 017 ng/ml, p = .122), cord blood BDNF values were higher in female infants compared to male infants (0.85 +/- 0.33 ng/ml vs. 0.66 +/- 0.23 ng/ml, p = .001) and in patients using insulin compared to those not using insulin in the GDM group (0.78 +/- 0.14 ng/ml vs. 0.62 +/- 0.09 ng/ml, p < .001). This study found that GDM has no effect on cord blood BDNF levels. More in-depth studies with larger series are needed to validate the results of the present study.Impact statement What is already known on this subject? Gestational diabetes mellitus (GDM) negatively affects the foetal neurodevelopment due to inflammation and oxidative stress caused by hyperglycaemia. Brain-derived neurotrophic factor (BDNF) expression has been shown to modulate oxidative stress and inflammation, and there may be a relationship between varying BDNF concentrations and GDM. What do the results of this study add? Our study showed that no significant differences were noted between the groups with respect to cord blood BDNF levels, cord blood BDNF values were higher in female infants compared to male infants, and in patients using insulin compared to those not using insulin in the GDM group. What are the implications of these findings for clinical practice and/or further research? GDM negatively affects the foetal neurodevelopment due to inflammation and oxidative stress caused by hyperglycaemia. BDNF expression has also been shown to modulate oxidative stress and inflammation, and there may be a relationship between varying BDNF concentrations and GDM. The association between BDNF expression and GDM has not been clearly elucidated in the literature. More in-depth studies with larger series are needed to determine this relationship.en_US
dc.identifier.doi10.1080/01443615.2021.2006159
dc.identifier.endpage1102en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue5en_US
dc.identifier.pmid34989285en_US
dc.identifier.scopus2-s2.0-85122502980en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1097en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2021.2006159
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12998
dc.identifier.volume42en_US
dc.identifier.wosWOS:000739736500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Obstetrics And Gynaecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectGestational Diabetes Mellitusen_US
dc.subjectUmbilical Cord Blooden_US
dc.titleFoetal umbilical cord brain-derived neurotrophic factor (BDNF) levels in pregnancy with gestational diabetes mellitusen_US
dc.typeArticleen_US

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