Telomere Length in Idiopathic Recurrent Pregnancy Loss

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dc.contributor.authorOnat, Taylan
dc.contributor.authorCaltekin, Melike Demir
dc.contributor.authorInandiklioglu, Nihal
dc.contributor.authorBaser, Emre
dc.contributor.authorKirmizi, Demet Aydogan
dc.contributor.authorKara, Mustafa
dc.contributor.authorErcan, Fedi
dc.date.accessioned2024-02-23T14:16:50Z
dc.date.available2024-02-23T14:16:50Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective Telomere length is used as an indicator of biological aging. It is well known that one of the most remarkable risk factors of recurrent pregnancy losses is advanced maternal age. The objective of this study was to investigate the correlation between idiopathic recurrent pregnancy loss and telomere length. Method The study group included 40 women, while the control group consisted of 41 healthy women whose age and body mass index were matched. A venous blood sample was taken from all participants into EDTA tubes in the early follicular phase, and telomere length was measured through the qPCR technique. Results When the mean TL of the groups was compared, it was determined that TL was significantly shorter among the iRPL group (7763.89924.58 base pair) compared to the control group (8398.84 +/- 1102.95 base pair) (p<0.006). Whereas FSH and E2 were higher in the iRPL group, TAFC was lower (p<0.001). When the correlation between telomere length and endocrine parameters was statistically tested in the iRPL group, a negative correlation was found between FSH and telomere length (r=-0.437; p<0.001). Conclusion Shortened telomere length might play a role in the etiology of iRPL. We are of the opinion that patients with RPL should be screened for the presence of cardiovascular diseases and other chronic diseases, as is the case for POF.en_US
dc.description.sponsorshipYozgat Bozok University Project Co-ordination Application and Research Center [6602a-TF/18-202]en_US
dc.description.sponsorshipThis study was supported by Yozgat Bozok University Project Co-ordination Application and Research Center (6602a-TF/18-202).en_US
dc.identifier.doi10.1055/a-1345-9821
dc.identifier.endpage124en_US
dc.identifier.issn0948-2393
dc.identifier.issn1439-1651
dc.identifier.issue2en_US
dc.identifier.pmid33530115en_US
dc.identifier.scopus2-s2.0-85100566765en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1055/a-1345-9821
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12824
dc.identifier.volume225en_US
dc.identifier.wosWOS:000613901100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofZeitschrift Fur Geburtshilfe Und Neonatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRecurrent Pregnancy Lossen_US
dc.subjectTelomere Lengthen_US
dc.subjectBiological Ageen_US
dc.titleTelomere Length in Idiopathic Recurrent Pregnancy Lossen_US
dc.typeArticleen_US

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