A cross-sectional study to assess the association between major depression and inflammatory markers in patients with acute ischemic stroke

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dc.contributor.authorKozak, Hasan Huseyin
dc.contributor.authorUguz, Faruk
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorTokgoz, Osman Serhat
dc.contributor.authorGuney, Figen
dc.contributor.authorOzer, Nejla
dc.date.accessioned2024-02-23T14:37:55Z
dc.date.available2024-02-23T14:37:55Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractBackground: Increased interest in the relationship between affective disorder and long-term health consequences has generated recent examinations of depression and stroke. Observations suggest that depressive disorder is associated with abnormal physiological and immunological responses and a resultant increase in inflammatory markers. Given the high prevalence of stroke and associated costs for the community, it is important to understand the mechanisms that may impact on the outcome to achieve the best possible prognosis. Aims: The view that inflammatory factors contribute to depression is predicated on findings that circulating cytokines and other inflammatory factors are increased in depressed patients. Therefore, it has been hypothesized that inflammation could be one of the mechanisms by which depression increases risk for ischemic stroke. Our aim was to determine whether there is any relationship between major depression and tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), IL-18, brain-derived neurotrophic factor (BDNF), and neuron-specific enolase (NSE) in patients with acute ischemic stroke (AIS). Study Design: This was as a cross-sectional design. Materials and Methods: This study has a cross-sectional design, and it was conducted in Necmettin Erbakan University, the Meram Faculty of Medicine in Konya, Turkey, between 2014 and 2015. Fifty-three AIS patients admitted to the hospital within the first 24 h after stroke onset were recruited. Major depression was ascertained by means of the structured clinical interview for the diagnostic and statistical manual of mental disorders, Fourth Edition/Clinical Version. The enzyme-linked immunosorbent assay was used to measure the serum levels of TNF-alpha, IL-1 beta, IL-18, BDNF, and NSE at admission. Results: A total of 53 patients with a mean age of 65.9 years were recruited. Of these patients, 17 (32.1%) had major depression. Depressive and nondepressive patients had similar demographical and clinical features. There was no significant statistical difference between depressive and nondepressive patients with AIS with respect to levels of TNF-alpha, IL-1 beta, IL-18, BDNF, and NSE. Conclusion: This study suggests that in patients who have experienced AIS, there is no significant relationship between major depression and basal proinflammatory cytokines (TNF-alpha, IL-1 beta, IL-18), BDNF, and NSE.en_US
dc.description.sponsorshipresearch foundation of the Meram Medical Faculty of Necmettin Erbakan Universityen_US
dc.description.sponsorshipThis research was supported by the research foundation of the Meram Medical Faculty of Necmettin Erbakan University.en_US
dc.identifier.doi10.4103/psychiatry.IndianJPsychiatry_175_18
dc.identifier.endpage289en_US
dc.identifier.issn0019-5545
dc.identifier.issn1998-3794
dc.identifier.issue3en_US
dc.identifier.pmid31142907en_US
dc.identifier.scopus2-s2.0-85066147009en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.4103/psychiatry.IndianJPsychiatry_175_18
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16286
dc.identifier.volume61en_US
dc.identifier.wosWOS:000468922200012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytokineen_US
dc.subjectDepressionen_US
dc.subjectInflammationen_US
dc.subjectStrokeen_US
dc.titleA cross-sectional study to assess the association between major depression and inflammatory markers in patients with acute ischemic strokeen_US
dc.typeArticleen_US

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