Effects of strontium ranelate on sutural bone formation: a histological and immunohistochemical study

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dc.contributor.authorKaratas, Orhan H.
dc.contributor.authorToy, Ebubekir
dc.contributor.authorDemir, Abdullah
dc.contributor.authorToy, Hatice
dc.contributor.authorKozacioglu, Sumeyye
dc.date.accessioned2024-02-23T14:48:55Z
dc.date.available2024-02-23T14:48:55Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractAim: Rapid maxillary expansion is performed to correct a skeletal transverse deficiency of the maxilla, which is a frequently encountered orthodontic anomaly. Strontium ranelate (SrR) is a novel agent that has a dual action, involving anti-resorptive and bone-forming effects. The aim of this study was to evaluate the effects of systemically applied SrR on osteoblastic bone formation after maxillary expansion on the mid-palatal suture of rats using histological and immunohistochemical tests. Materials and methods: A total of 24 Wistar rats were randomly divided into two equal groups. In all animals, five-day inter-premaxillary expansion was applied and maintained for a seven-day retention period, during which 625mg/kg/day SrR diluted with saline solution was administered orally to the experimental group. The rats were sacrificed and the tissues prepared for histological and immunohistochemical examinations after the retention period. Results: Osteoblastic activity and the width of the blood vessels in the suture area were significantly increased in the SrR group compared with the control group (p < 0.05). Ossification was also observed to be active under light microscopy by staining with hematoxylin and eosin in the experimental group. Immunohistochemical labelling performed using osteonectin, osteocalcin, TGF-beta and VEGF antibodies revealed significant immunoreactivity in the experimental group (p < 0.05). Conclusion: It may be concluded that SrR contributed to stimulatory osteogenesis in the expansion region. Therefore, a retention period may be shortened and relapse possibly reduced, following the application of SrR after the expansion.en_US
dc.description.sponsorshipScientific Research Projects Coordinator in Inonii University [2012-129]en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordinator in Inonii University (2012-129).en_US
dc.identifier.endpage147en_US
dc.identifier.issn0587-3908
dc.identifier.issue2en_US
dc.identifier.pmid29509338en_US
dc.identifier.startpage139en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17888
dc.identifier.volume32en_US
dc.identifier.wosWOS:000404498700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAustralian Soc Orthodontists Incen_US
dc.relation.ispartofAustralian Orthodontic Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleEffects of strontium ranelate on sutural bone formation: a histological and immunohistochemical studyen_US
dc.typeArticleen_US

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