Intra-ovarian stem cell transplantation in management of premature ovarian insufficiency: towards the induced Oogonial Stem Cell (iOSC)

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dc.contributor.authorCelik, Onder
dc.contributor.authorAk, Mehmet
dc.contributor.authorSahin, Erdem
dc.contributor.authorSenturk, Senol
dc.contributor.authorUgur, Kader
dc.contributor.authorCelik, Sudenaz
dc.contributor.authorCelik, Nilufer
dc.date.accessioned2024-02-23T14:31:37Z
dc.date.available2024-02-23T14:31:37Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractThe specialized resident-stem cells in gonads are tasked with restorating damaged ovarian cells following injury to maintain sequential reproductive events. When we talk about premature ovarian insufficiency (POI) we accept the existence of decreased stem cell and their regenerative abilities. The present study was to explain how restorating damaged ovarian cells following injury to maintain sequential reproductive events in evidence-based medicine indexed in PubMed and Web of Science. The exact mechanism is unclear stem cells transfer may improve compromised ovarian function and fertility outcome in women with POI. Soluble factors secreted by stem cell may rescue impaired mitochondrial function in oogonial stem cells, enhance metabolic capacity of resident stem cells, induce local neovascularization in the ovary, and activate gene shifting between transferred stem cells and germ cell precursors. This review may provide insight into how stem cells show some of their beneficial effects on compromised ovarian microenvironment and germ cell niche and paves the way for clinical trials for improving ovarian function of women with POI. We also had the opportunity to share our hypothesis about the design and development of induced oogonial stem cell (iOSC) and its use in POI.en_US
dc.identifier.doi10.14715/cmb/2019.66.1.19
dc.identifier.endpage121en_US
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue1en_US
dc.identifier.pmid32359395en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage114en_US
dc.identifier.urihttps://doi.org/10.14715/cmb/2019.66.1.19
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15253
dc.identifier.volume66en_US
dc.identifier.wosWOS:000529791700019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherC M B Assocen_US
dc.relation.ispartofCellular And Molecular Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOogonial Stem Cellen_US
dc.subjectStem Cell Transplantationen_US
dc.subjectPremature Ovarian Insufficiencyen_US
dc.titleIntra-ovarian stem cell transplantation in management of premature ovarian insufficiency: towards the induced Oogonial Stem Cell (iOSC)en_US
dc.typeReview Articleen_US

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