3?,4?-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia

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dc.contributor.authorOz, Mehmet
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorCaliskan, Merve
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorAtalik, K. Esra Nurullahoglu
dc.date.accessioned2024-02-23T14:27:12Z
dc.date.available2024-02-23T14:27:12Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractObjectives: In the present study, effects of 3', 4'-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. Methods: The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i. p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively. Results: In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05). Discussion: All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.en_US
dc.identifier.doi10.1179/1476830514Y.0000000159
dc.identifier.endpage126en_US
dc.identifier.issn1028-415X
dc.identifier.issn1476-8305
dc.identifier.issue2en_US
dc.identifier.pmid25290491en_US
dc.identifier.scopus2-s2.0-84978531959en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1179/1476830514Y.0000000159
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14484
dc.identifier.volume20en_US
dc.identifier.wosWOS:000399670000005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNutritional Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiohfen_US
dc.subjectStrokeen_US
dc.subjectLearning And Memoryen_US
dc.subjectAnxiety-Like Behavioren_US
dc.title3?,4?-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemiaen_US
dc.typeArticleen_US

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