Yazar "Alkan, Selman" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Changes in cerebral oxygen saturation with the Trendelenburg position and increased intraabdominal pressure in laparocopic rectal surgery(Turkish Surgical Assoc, 2022) Alkan, Selman; Cakir, Murat; Senturk, Mustafa; Varman, Alper; Buyukbezirci, Gulcin; Yildirim, Mehmet Aykut; Bicer, MehmetObjective: Position changes and increased intra-abdominal pressure in laparoscopic interventions lead to some physiopathological changes. There is no definite information in the literature regarding cerebral oxygen saturation in patients undergoing colorectal surgery. Our aim was to investigate whether there is oxygen saturation change in the brain tissue in pneumoperitoneum and the Trendelenburg position during laparoscopic rectal surgery. Material and Methods: Cerebral oxygen saturation was measured in 35 patients who underwent laparoscopic rectal surgery in the Trendelenburg position. Measurements were made under general anesthesia in the pneumoperitoneum and the Trendelenburg position. Results: The values that are statistically affected by the position are systolic blood pressure, mean arterial blood pressure and cerebral oxygen saturation. The Trendelenburg position does not disturb the cerebral oxygen saturation and it causes an increase in saturation. After pneumoperitoneum occurred, changes in systolic blood pressure, mean arterial blood pressure and brain oxygen saturation were detected. Cerebral oxygen saturation increases with the formation of pneumoperitoneum. Conclusion: The Trendelenburg position and increased intraabdominal pressure during laparoscopic rectal surgery do not impair brain oxygen saturation.Öğe Comparison of primary repair and repair with polyglycolic acid coated tube in recurrent laryngeal nerve cuts (an experimental study)(Excerpta Medica Inc-Elsevier Science Inc, 2020) Senturk, Mustafa; Cakir, Murat; Tekin, Ahmet; Kucukkartallar, Tevfik; Yildirim, Mehmet Aykut; Alkan, Selman; Findik, SiddikaBackground: Recurrent laryngeal nerve (RLN) injury is an important complication of thyroid surgery. In our study, we aimed to compare the effects of primary repair and polyglycolic acid (PGA) coated tube repair on nerve function and regeneration in RLN cuts in rats. Methods: Twenty seven rats were used for the study. Group-1 with only nerve cuts, group-2 with primary repair, and group-3 with conduit repair. The study was planned over two-stage surgery. In the first step, nerve defect formation and nerve repair were performed in the same session. In the second step, samples were taken from the subjects for histopathological. Results: Vocal cord mobility was proportionally higher in group-3 than other groups. However, there was no statistically significant difference between the groups (p < 0.239). The mean number of highest axons were detected the group-3. Conclusions: We think that PGA coated conduit can provide a more accurate orientation of nerve fibers by creating an isolated environment when compared to the primary repair. And this may be the cause of functional improvement in the nerve. (C) 2019 Elsevier Inc. All rights reserved.Öğe Effective anticancer agents based-on two Pillar[5]arene derivatives for pancreas cancer cell lines: synthesis, apoptotic effect, caspase pathway(Springer, 2023) Karaselek, Mehmet Ali; Kuccukturk, Serkan; Duran, Tugce; Kursunlu, Ahmed Nuri; Ozmen, Mustafa; Bozdag, Ceren; Alkan, SelmanThis study aimed to evaluate the possible anticancer effects of two different pillar[5]arene derivatives (5Q-[P5] and 10Q-P[5]) on two different pancreatic cancer cell lines in vitro. For this purpose, changes in the expression of major genes that play a role in apoptosis and caspase pathways were investigated. Panc-1 and BxPC-3 cell lines were used in the study and the cytotoxic dose of pillar[5]arenes was determined by the MTT method. Changes in gene expression after pillar[5]arenes treatment were evaluated by real-time polymerase chain reaction (qPCR). Apoptosis was studied by flow cytometry. As a result of analysis, it was determined that proapoptotic genes and genes involved in major caspase activation were upregulated and antiapoptotic genes were down-regulated in Panc-1 cell line treated with pillar[5]arenes. Flow cytometric apoptosis analysis also showed an increased apoptosis rate in this cell line. On the contrary, although MTT analysis showed cytotoxic effect in BxPC-3 cell line treated with two pillar[5]arene derivatives, the apoptosis pathway was not active. This suggested that it may activate different death pathways for BxPC-3 cell line. Thus, it was first determined that the pillar[5]arene derivatives reduced cancer cell proliferation on pancreatic cancer cells.Öğe Emergency and elective approaches to femoral hernias(Bayrakol Medical Publisher, 2023) Varman, Alper; Alkan, SelmanAim: Femoral hernias often occur with incarceration, resulting in obstruction and strangulation. They usually require emergency surgical intervention and sometimes bowel resection may be required. The aim of this study is to compare the surgical results of femoral hernia cases in emergency or elective conditions.Material and Methods: The medical files of 38 patients who underwent surgery in January 2015-March 2022 with the diagnosis of femoral hernia at the general surgery service at Necmettin Erbakan University Meram Medical Faculty Hospital were retrospectively examined. Demographic data, party-relevant information, surgical technique, content of sac, length of hospital stay, recurrence and complications according to the last polyclinic were retrieved from the patient files and electronic database.Results: The gender distribution of the cases was 81.6% (n=31) females and 11.5% (n=7) males. The mean age was 45.74 +/- 16.11 years. The complication rate among the groups was significantly higher in those undergoing emergency surgery (p=0.014). No significant difference was found between the two groups in terms of the side of hernia (p=0.671).Discussion: Femoral hernia is more common in women. There are different repair techniques. More extensive prospective research is needed to compare surgical techniques and outcomes.Öğe The Investigation of 14 Appendiceal Mucocele Cases Encountered in 4850 Appendectomy Patients(Springer, 2021) Senturk, Mustafa; Yavuz, Yusuf; Alkan, Selman; Kafadar, Mehmet TolgaBackground Appendiceal mucocele is a rarely seen disease which occurs when the appendix lumen is filled and obstructed by mucous. In our study, we aimed to reveal the surgical approach of our clinic, features of tumors, and clinical presentations in line with literature in cases of appendix mucocele. Methods Fourteen appendix mucocele patients who were admitted in our hospital between 2012 and 2019 were examined retrospectively in the electronic recording medium. Our patients were evaluated in terms of age, gender, clinical status, operation, imaging results, and pathology results. Results Of the fourteen patients, 12 applied to the emergency department and 2 to the general surgery clinic. All of our patients had abdominal pain at the time of admission. In the physical examination, 5 (35%) patients had defenses, 10 (71%) patients had rebound tenderness, and 12 (85%) patients had tenderness. In preoperative imaging studies, 11 patients were interpreted as having acute appendicitis and 3 patients were evaluated as having appendix mucocele. The pathological results were reported as 6 patients had appendiceal mucocele and 8 patients had appendiceal mucocele together with acute appendicitis. Conclusion Appendiceal mucocele is a disease which generally causes similar clinical findings of acute appendicitis. Ultrasound and CT may be useful in preoperative diagnosis. Surgical treatment options of mucocele are open or laparoscopic appendectomy, cecum resection, and right hemicolectomy. Although its incidence is low, due to pseudomyxoma peritonei, it is a pathology that requires careful surgery.Öğe Our clinical experiences in patients with de novo and secondary metastatic breast cancers(Bayrakol Medical Publisher, 2023) Tasci, Halil Ibrahim; Alkan, Selman; Varman, AlperAim: While breast cancer may be de novo, that is, metastatic at the time of diagnosis, a local tumor at initial diagnosis may metastasize to other regions over the course of treatment and follow-up. This study aimed to reveal the clinical, pathological, and survival differences in patients with de novo metastatic and secondary metastatic breast cancer who were followed up and treated in our clinic, and to investigate factors that may have an effect on survival.Material and Methods: The data of female patients who were diagnosed with metastatic breast cancer, treated, and followed up in our clinic between January 2000 and May 2021 were retrospectively analyzed. Patients were divided into two groups: the de novo metastatic disease group (Group 1) and the secondary metastatic disease group (Group 2). Clinical and pathological data of the groups were analyzed.Results: Patients with de novo metastatic disease most commonly had bone metastases. But in the secondary metastatic disease group, the most common metastasis type was multiorgan metastases. The rate of triple negativity was significantly lower in Group 1. When the groups were analyzed in terms of survival, the median time was 77 +/- 10.89 months in the de novo metastatic group and 66 +/- 10.15 months in the secondary metastatic group (p=0.05).Discussion: Our study demonstrated that de novo metastatic breast cancers had a better prognosis than secondary metastatic breast cancers even though they tend to metastasize early.Öğe Papiller tiroid kanserlerinde preoperatif ince iğne aspirasyon biyopsisinde BRAFV600e pozitifliğinin nüks ve kötü prognozla ilişkisi(2019) Alkan, Selman; Aksoy, FarukPapiller tiroid kanserlerinde cerrahi sonrası oluşan nükslerde BRAFv600e pozitifliğinin preoperatif ince iğne aspirasyon biyopsilerinden tespit edilebilmesi ve bu pozitifliğin nüksü etkileyen diğer faktörlerle beraber nüks ile ilişkisini ortaya koymak. Yöntem: Papiller tiroid kanseri nedeni ile daha önce ameliyat edilmiş ve nüks gelişmiş olan hastaların ameliyat öncesi yapılan ince iğne aspirasyon biyopsi preparatları temin edildi. Bu preparatlar üzerinden kanserli bölge işaretlendi ve işaretli alanlardaki hücrelerden DNA izole edildi. İzole edilen DNA üzerinde pyrosequence dizi analizi yöntemi ile BRAFV600E mutasyonu varlığı araştırıldı. Hastaların papiller tiroid kanseri açısından diğer prognostik kriterleri de kayıt altına alınarak BRAFV600E mutasyonu ile ilişkileri istatistiksel olarak analiz edildi. Bulgular: Papiller tiroid kanserlerinde nüks nedeni ile ameliyat edilen hastalarda tüm çalışma grubunda BRAFV600E pozitifliği oranı %70,8 olarak bulunmuştur. Ayrıca kapsül invazyonu, yumuşak doku invazyonu, evresi, nüks zamanı ve lenf nodu metastazı ile BRAFV600E mutasyonu arasında pozitif korelasyon gösterilmiştir. Sonuç: BRAFV600E mutasyonu ile papiller tiroid kanserlerindeki bazı kötü prognostik kriterler arasında pozitif ilişki gösterilmiş olmasına rağmen bu konuda karşılaştırmalı geniş seriler ile yeni çalışmalara ihtiyaç olduğu bir gerçektir.