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    The association of decreased testosterone with atherosclerosis and inflammation in male predialysis patients with chronic kidney disease
    (Elsevier, 2020) Aydemir, Harun; Guney, Ibrahim; Duran, Cevdet; Gencer, Vedat; Akbayrak, Sahabettin; Kurku, Huseyin; Akgul, Yavuz Sultan Selim
    Purpose: To investigate the frequency of hypogonadism and its relationship to inflammation and carotid intima-media thickness (CIMT) in male patients with predialysis chronic kidney disease (CKD). Methods: A total of 105 patients with CKD, 55 (52.4%) as stage 3, 33 (31.4%) as stage 4 and 17 (16.2%) as stage 5, were enrolled into the study. Total testosterone (TT) and free testosterone (FT), interleukin 6 (IL-6), C-reactive protein (CRP) levels, and CIMT were measured. Results: According to TT and FT, hypogonadism was detected in 18 (17.1%) and 22 (20.9%) patients, respectively. There was no difference in terms of TT and FT, CIMT, CRP and IL-6 between the stages of CKD. According to TT, the patients with hypogonadism had significantly higher CRP and high-density lipoprotein cholesterol (HDL-cholesterol) levels (p=0.004 and p=0.005, respectively). There was no significant difference in other parameters. According to FT, the patients with hypogonadism had significantly higher CRP (p=0.017), and TT were negatively correlated with body mass index (BMI), waist circumference (WC), hip circumference, and CRP levels. FT was negatively correlated with age, waist circumference, systolic blood pressure, diastolic blood pressure (DBP) and CRP. Conclusions: The frequency of hypogonadism was found around 17-21% among the patients with CKD. Despite similar IL-6 and CIMT levels, CRP was found to be higher in the patients with hypogonadism. We consider that further studies with larger populations are needed to elucidate the entity. (C) 2020 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.
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    Tear Function Alterations and Conjunctival Impression Cytology Findings in Patients With Gout
    (Lippincott Williams & Wilkins, 2021) Belviranli, Selman; Turk, Huseyin B.; Oltulu, Pembe; Turk, Nazli; Mirza, Enver; Kucuk, Adem; Aydemir, Harun
    Objectives: The aim of this study was to evaluate the tear functions and conjunctival impression cytology (CIC) findings of patients with gout and compare them with healthy controls. Methods: Thirty-four patients with gout (group 1) and 32 age-matched and gender-matched healthy individuals (group 2) were included in this cross-sectional study. Schirmer 1 test, tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) score, and CIC grade were evaluated and compared between the groups. Results: There was no significant difference between the groups in gender and age (P=0.923 and P=0.078, respectively). The mean of Schirmer 1 test result was significantly lower in group 1 (9.74 +/- 6.03 mm) than that in group 2 (17.16 +/- 9.33 mm) (P<0.001). The TBUT was also significantly lower in group 1 (7.00 +/- 2.09 seconds) than that in group 2 (12.75 +/- 5.25 seconds) (P<0.001). The OSDI score (20.04 +/- 12.92) was significantly higher in group 1 than that in group 2 (6.19 +/- 10.07) (P<0.001). Although 10 patients (29.4%) in group 1 had the CIC grade of 2 to 3, none of the controls had CIC grade 2 to 3. The mean CIC grade in group 1 (1.15 +/- 0.89) was significantly higher than that in group 2 (0.47 +/- 0.51) (P<0.001). Conclusions: The results of this study suggest that ocular surface alterations assessed by CIC and tear function abnormalities are more common in patients with gout.
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    Thoracic Complications in Behcet's Disease: Imaging Findings
    (Hindawi Ltd, 2020) Odev, Kemal; Tunc, Recep; Varol, Salih; Aydemir, Harun; Yilmaz, Pinar Didem; Korkmaz, Celalettin
    Behcet's disease (BD) causes vascular inflammation and necrosis in a wide range of organs and tissues. In the thorax, it may cause vascular complications, affecting the aorta, brachiocephalic arteries, bronchial arteries, pulmonary arteries, pulmonary veins, capillaries, and mediastinal and thoracic inlet veins. In BD, chest radiograph is commonly used for the initial assessment of pulmonary symptoms and complications and for follow-up and establishment of the response to treatment. With the advancement of helical or multislice computed tomography (CT) technologies, such noninvasive imaging techniques have been employed for the diagnosis of vascular lesions, vascular complications, and pulmonary parenchymal manifestations of BD. CT scan (especially, CT angiography) has been used to determine the presence and severity of pulmonary complications without resorting to more invasive procedures, in conjunction with gadolinium-enhanced three-dimensional (3D) gradient-echo magnetic resonance (MR) imaging with the subtraction of arterial phase images. These radiologic methods have characteristics that are complementary to each other in diagnosis of the thoracic complications in BD. 3D ultrashort echo time (UTE) MR imaging (MRI) could potentially yield superior image quality for pulmonary vessels and lung parenchyma when compared with breath-hold 3D MR angiography.