Tear Function Alterations and Conjunctival Impression Cytology Findings in Patients With Gout
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Lippincott Williams & Wilkins
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: The aim of this study was to evaluate the tear functions and conjunctival impression cytology (CIC) findings of patients with gout and compare them with healthy controls. Methods: Thirty-four patients with gout (group 1) and 32 age-matched and gender-matched healthy individuals (group 2) were included in this cross-sectional study. Schirmer 1 test, tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) score, and CIC grade were evaluated and compared between the groups. Results: There was no significant difference between the groups in gender and age (P=0.923 and P=0.078, respectively). The mean of Schirmer 1 test result was significantly lower in group 1 (9.74 +/- 6.03 mm) than that in group 2 (17.16 +/- 9.33 mm) (P<0.001). The TBUT was also significantly lower in group 1 (7.00 +/- 2.09 seconds) than that in group 2 (12.75 +/- 5.25 seconds) (P<0.001). The OSDI score (20.04 +/- 12.92) was significantly higher in group 1 than that in group 2 (6.19 +/- 10.07) (P<0.001). Although 10 patients (29.4%) in group 1 had the CIC grade of 2 to 3, none of the controls had CIC grade 2 to 3. The mean CIC grade in group 1 (1.15 +/- 0.89) was significantly higher than that in group 2 (0.47 +/- 0.51) (P<0.001). Conclusions: The results of this study suggest that ocular surface alterations assessed by CIC and tear function abnormalities are more common in patients with gout.
Açıklama
Anahtar Kelimeler
Schirmer Test, Tear Breakup Time, Ocular Surface Disease Index, Conjunctival Squamous Metaplasia, Goblet Cell Loss, Dry Eye Disease
Kaynak
Eye & Contact Lens-Science And Clinical Practice
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
47
Sayı
12
