Tear Function Alterations and Conjunctival Impression Cytology Findings in Patients With Gout

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dc.contributor.authorBelviranli, Selman
dc.contributor.authorTurk, Huseyin B.
dc.contributor.authorOltulu, Pembe
dc.contributor.authorTurk, Nazli
dc.contributor.authorMirza, Enver
dc.contributor.authorKucuk, Adem
dc.contributor.authorAydemir, Harun
dc.date.accessioned2024-02-23T14:21:10Z
dc.date.available2024-02-23T14:21:10Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjectives: The aim of this study was to evaluate the tear functions and conjunctival impression cytology (CIC) findings of patients with gout and compare them with healthy controls. Methods: Thirty-four patients with gout (group 1) and 32 age-matched and gender-matched healthy individuals (group 2) were included in this cross-sectional study. Schirmer 1 test, tear breakup time (TBUT), Ocular Surface Disease Index (OSDI) score, and CIC grade were evaluated and compared between the groups. Results: There was no significant difference between the groups in gender and age (P=0.923 and P=0.078, respectively). The mean of Schirmer 1 test result was significantly lower in group 1 (9.74 +/- 6.03 mm) than that in group 2 (17.16 +/- 9.33 mm) (P<0.001). The TBUT was also significantly lower in group 1 (7.00 +/- 2.09 seconds) than that in group 2 (12.75 +/- 5.25 seconds) (P<0.001). The OSDI score (20.04 +/- 12.92) was significantly higher in group 1 than that in group 2 (6.19 +/- 10.07) (P<0.001). Although 10 patients (29.4%) in group 1 had the CIC grade of 2 to 3, none of the controls had CIC grade 2 to 3. The mean CIC grade in group 1 (1.15 +/- 0.89) was significantly higher than that in group 2 (0.47 +/- 0.51) (P<0.001). Conclusions: The results of this study suggest that ocular surface alterations assessed by CIC and tear function abnormalities are more common in patients with gout.en_US
dc.identifier.doi10.1097/ICL.0000000000000832
dc.identifier.endpage650en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue12en_US
dc.identifier.pmid34417788en_US
dc.identifier.scopus2-s2.0-85122111746en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage647en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000832
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13462
dc.identifier.volume47en_US
dc.identifier.wosWOS:000863357900005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science And Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSchirmer Testen_US
dc.subjectTear Breakup Timeen_US
dc.subjectOcular Surface Disease Indexen_US
dc.subjectConjunctival Squamous Metaplasiaen_US
dc.subjectGoblet Cell Lossen_US
dc.subjectDry Eye Diseaseen_US
dc.titleTear Function Alterations and Conjunctival Impression Cytology Findings in Patients With Gouten_US
dc.typeArticleen_US

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