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    THE COMPARISON OF VITAMIN D LEVELS OF HEALTHY AND GESTATIONAL DIABETIC PREGNANT WOMEN
    (Derman Medical Publ, 2017) Pekgor, Selma; Basaran, Mustafa; Cihan, Fatma Goksin; Pekgor, Ahmet
    Aim: To evaluate and compare 25-hydroxyvitamin D [25(OH)D3] levels of women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT). Material and Method: A total of 40 women (20 with GDM and 20 with NGT) admitted to the clinic of obstetrics and gynecology due to follow-ups between the 24th and 28th gestational weeks and exposed to 50 and/or 100 gr oral glucose tolerance testing (OGTT) were enrolled into this prospective case-controlled study. Patients with GDM and controls with NGT were defined according to the 2013 criteria of the American College of Obstetricians and Gynecologists (ACOG). Age, height, weight, body mass index (BMI), history of previous diseases and surgeries, vitamin D replacement, clothing style (in this region 95% of participants dress in a style that prevents the sun from reaching skin) exercising status, and familial history were recorded. Serum samples were collected between the 24th and 28th gestational weeks to measure 25(OH)D3 levels via the chemiluminescence method. Results: Mean 25(OH)D3 levels were found as 8.71 +/- 3.36 ng/mL (ranging from 4.20 to 18.84). Vitamin D deficiency (< 10 ng/mL) and insufficiency( 10-30 ng/ml) were observed at the rate of 70% and 30%, respectively. 25(OH)D3 levels were 9.40 +/- 3.53ng/mL in patients with GDM and 8.0 +/- 3.11 ng/mL in controls with NGT. In terms of vitamin D deficiency, no statistically significant difference was found between the GDM and NGT groups. Discussion: 25(OH)D3 levels were found to be similar or lower in patients with GDM and those with NGT. We consider that prospective, randomized-controlled and comprehensive studies with larger populations are needed to illuminate the role of 25(OH)D3 levels in the development of GDM.
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    Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels
    (Pergamon-Elsevier Science Ltd, 2013) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, Gulsum
    Objectives: The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD. Methods: Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery. Results: Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels. Conclusions: The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. (C) 2013 Elsevier Inc. All rights reserved.
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    Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels
    (W B Saunders Co-Elsevier Inc, 2014) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, Gulsum
    Objective: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-alpha) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-alpha levels in newborn infants of women with and without OCD. Methods: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-alpha level was obtained from the umbilical cord during delivery. Results: Cord blood TNF-alpha levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-alpha levels in newborn infants of women with OCD. Conclusion: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-alpha. (C) 2014 Elsevier Inc. All rights reserved.