Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-alpha) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-alpha levels in newborn infants of women with and without OCD. Methods: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-alpha level was obtained from the umbilical cord during delivery. Results: Cord blood TNF-alpha levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-alpha levels in newborn infants of women with OCD. Conclusion: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-alpha. (C) 2014 Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
[Keyword Not Available]
Kaynak
Comprehensive Psychiatry
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
55
Sayı
4
