Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels

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dc.contributor.authorUguz, Faruk
dc.contributor.authorSonmez, Erdem Onder
dc.contributor.authorSahingoz, Mine
dc.contributor.authorGokmen, Zeynel
dc.contributor.authorBasaran, Mustafa
dc.contributor.authorGezginc, Kazim
dc.contributor.authorSonmez, Gulsum
dc.date.accessioned2024-02-23T14:02:37Z
dc.date.available2024-02-23T14:02:37Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-alpha) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-alpha levels in newborn infants of women with and without OCD. Methods: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-alpha level was obtained from the umbilical cord during delivery. Results: Cord blood TNF-alpha levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-alpha levels in newborn infants of women with OCD. Conclusion: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-alpha. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.comppsych.2013.12.018
dc.identifier.endpage865en_US
dc.identifier.issn0010-440X
dc.identifier.issn1532-8384
dc.identifier.issue4en_US
dc.identifier.pmid24480417en_US
dc.identifier.scopus2-s2.0-84898820997en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage861en_US
dc.identifier.urihttps://doi.org/10.1016/j.comppsych.2013.12.018
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11768
dc.identifier.volume55en_US
dc.identifier.wosWOS:000335094700016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofComprehensive Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleNeuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levelsen_US
dc.typeArticleen_US

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