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Öğe Carbon Monoxide Poisoning and Mechanical Ventilation: Case Report Literature Review(Aves, 2010) Cander, Basar; Dundar, Z. Defne; Yaylali, Cetin; Bayir, Aysegul; Girisgin, SadikCarbon monoxide poisoning is one of the most common lethal poisonings. Neurological or psychiatric sequelae occur in approximately 50-75% of survivors. Carbon monoxide poisoning can be treated with 100% oxygen or hyperbaric oxygen. The Glasgow Coma Scale (GKS) of the male patient who was admitted to our emergency department with CO intoxication due to a heater was 4. The patient's transport to a hyperbaric oxygen treatment center was considered but the conditions were not suitable for transport, so 100% oxygen treatment with mechanical ventilator was initiated. The patient was weaned from the mechanical ventilator at day 5 and he was extubated when his spontaneous breathing was adequate. He was discharged from hospital at the end of the follow-up period, day 14. His general condition was quite good and his GKS was 15 at discharge. Although most of the studies suggested that hyperbaric oxygen treatment was more effi cacious in carbon monoxide poisoning, other studies stated that there was no diff erence between hyperbaric oxygen and 100% oxygen treatment. There is a general opinion that the supportive treatment is very important for survival.Öğe Effectiveness of Dimethylthiourea Treatment in Experimentally Induced Acute Lung Injury by Smoke Inhalation in Rabbits(Aves, 2010) Kara, Hasan; Kafali, Ertugrul; Ozdinc, Serife; Bayir, Aysegul; Ahmet, A. K.; Cander, Baser; Kocak, SedatObjective: To investigate the effectivenes of Dimethylthiourea (DMTU) treatment on lung tissue in experimental smoke inhalation induced Acute Lung Injury (ALI) in rabbits. Materials and Methods: We used 24 New Zealand type female rabbits. We divided then into three groups as control, sham and DMTU (600 mg/kg). The treatment began immediately after smoke inhalation. The inhalation was performed by the bubble-smoke-intubation method. Arterial blood samples, plasma NO levels and biochemical analysis were performed at the 0th 3rd and 96th hours and tissue samples were collected from the lungat the end of the experiment. Results: Arterial pH and PaO2 levels were significantly high in the DMTU group, compared to the sham group. Blood urea, creatinine, ALT, AST levels were also significantly higher. NO levels did not differ between the groups. In the histopathologic examination; atelectasia, neutrophil penetration, edema, alveoli neutrophil and mucus findings were significantly different between DMTU and the other groups. Conclusion: In our study DMTU, an antioxidant agent, had positive effects on patient arterial blood pH, PaO2, blood urea, creatinine, ALT, AST, LDH levels and lung histology in experimental smoke inhalation induced ALI in rabbits.