Effectiveness of Dimethylthiourea Treatment in Experimentally Induced Acute Lung Injury by Smoke Inhalation in Rabbits
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Aves
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the effectivenes of Dimethylthiourea (DMTU) treatment on lung tissue in experimental smoke inhalation induced Acute Lung Injury (ALI) in rabbits. Materials and Methods: We used 24 New Zealand type female rabbits. We divided then into three groups as control, sham and DMTU (600 mg/kg). The treatment began immediately after smoke inhalation. The inhalation was performed by the bubble-smoke-intubation method. Arterial blood samples, plasma NO levels and biochemical analysis were performed at the 0th 3rd and 96th hours and tissue samples were collected from the lungat the end of the experiment. Results: Arterial pH and PaO2 levels were significantly high in the DMTU group, compared to the sham group. Blood urea, creatinine, ALT, AST levels were also significantly higher. NO levels did not differ between the groups. In the histopathologic examination; atelectasia, neutrophil penetration, edema, alveoli neutrophil and mucus findings were significantly different between DMTU and the other groups. Conclusion: In our study DMTU, an antioxidant agent, had positive effects on patient arterial blood pH, PaO2, blood urea, creatinine, ALT, AST, LDH levels and lung histology in experimental smoke inhalation induced ALI in rabbits.
Açıklama
Anahtar Kelimeler
Acute Lung Injury, Smoke Inhalation, Antioxidant, Dimethylthiourea
Kaynak
Eurasian Journal Of Emergency Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
9
Sayı
3
