Effectiveness of Dimethylthiourea Treatment in Experimentally Induced Acute Lung Injury by Smoke Inhalation in Rabbits

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dc.contributor.authorKara, Hasan
dc.contributor.authorKafali, Ertugrul
dc.contributor.authorOzdinc, Serife
dc.contributor.authorBayir, Aysegul
dc.contributor.authorAhmet, A. K.
dc.contributor.authorCander, Baser
dc.contributor.authorKocak, Sedat
dc.date.accessioned2024-02-23T14:38:00Z
dc.date.available2024-02-23T14:38:00Z
dc.date.issued2010
dc.departmentNEÜen_US
dc.description.abstractObjective: To investigate the effectivenes of Dimethylthiourea (DMTU) treatment on lung tissue in experimental smoke inhalation induced Acute Lung Injury (ALI) in rabbits. Materials and Methods: We used 24 New Zealand type female rabbits. We divided then into three groups as control, sham and DMTU (600 mg/kg). The treatment began immediately after smoke inhalation. The inhalation was performed by the bubble-smoke-intubation method. Arterial blood samples, plasma NO levels and biochemical analysis were performed at the 0th 3rd and 96th hours and tissue samples were collected from the lungat the end of the experiment. Results: Arterial pH and PaO2 levels were significantly high in the DMTU group, compared to the sham group. Blood urea, creatinine, ALT, AST levels were also significantly higher. NO levels did not differ between the groups. In the histopathologic examination; atelectasia, neutrophil penetration, edema, alveoli neutrophil and mucus findings were significantly different between DMTU and the other groups. Conclusion: In our study DMTU, an antioxidant agent, had positive effects on patient arterial blood pH, PaO2, blood urea, creatinine, ALT, AST, LDH levels and lung histology in experimental smoke inhalation induced ALI in rabbits.en_US
dc.identifier.doi10.4170/jaem.2010.69875
dc.identifier.endpage128en_US
dc.identifier.issn2149-5807
dc.identifier.issn2149-6048
dc.identifier.issue3en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.4170/jaem.2010.69875
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16330
dc.identifier.volume9en_US
dc.identifier.wosWOS:000420118700004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofEurasian Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectSmoke Inhalationen_US
dc.subjectAntioxidanten_US
dc.subjectDimethylthioureaen_US
dc.titleEffectiveness of Dimethylthiourea Treatment in Experimentally Induced Acute Lung Injury by Smoke Inhalation in Rabbitsen_US
dc.typeArticleen_US

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