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Öğe 8-F2-isoprostane, thioredoxin and thioredoxin reductase levels in children with obsessive-compulsive disorder(Taylor & Francis Ltd, 2018) Bilgic, Ayhan; Sivri, Rukiye Colak; Kilinc, IbrahimPurpose: Accumulating data demonstrate that oxidative stress may play a crucial role in obsessive-compulsive disorder (OCD). This study aimed to investigate the role of 8-F2-isoprostane, thioredoxin (Trx), and thioredoxin reductase (TrxR) in children with OCD.Materials and methods: Thirty-three drug-free children with OCD and 35 healthy controls were included in this study. The severity of OCD symptoms was assessed via the Children's Yale Brown Obsessive-Compulsive Scale. The severity of anxiety levels was determined through the Screen for Child Anxiety-Related Emotional Disorders. Plasma levels of 8-F2-isoprostane, Trx, and TrxR were measured using commercial enzyme-linked immunosorbent assay kits.Results: Plasma 8-F2-isoprostane, Trx, and TrxR levels did not show any significant differences between patient and control groups. There were no significant correlations between plasma levels of these antioxidants and severity of OCD.Conclusions: Findings of this study did not support the involvement of oxidative stress in the etiology of childhood OCD.Öğe ADHD symptoms, breast-feeding and obesity in children and adolescents(Wiley, 2015) Turkoglu, Serhat; Bilgic, Ayhan; Akca, Omer FarukBackgroundAttention-deficit-hyperactivity disorder (ADHD) has been found to be related to overweight/obesity in children and adolescents, but it is a heterogeneous disorder, and the relationships between the dimensions of ADHD and overweight/obesity are not clear. The aim of this study was to explore which dimensions of the disorder are specifically associated with overweight/obesity. MethodsThe study sample consisted of 300 treatment-naive children with ADHD and 75 healthy controls aged 7-17 years. The ADHD module of the Kiddie Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version was used to diagnose ADHD. The severity of ADHD symptoms was assessed via Conners' Parent Rating Scale (CPRS). The weight, height, and breast-feeding duration of the study samples and controls were recorded. Body mass index (BMI) was categorized according to the national age/sex-specific reference values. ResultsThe rate of overweight/obese children was higher in the ADHD group. The association between ADHD symptoms and BMI percentile scores was evaluated using structural equation modeling. In that model, it was observed that the Cognitive Problems/Inattentive and Oppositional subscores of the CPRS had a positive predictive effect on the BMI percentile scores, but breast-feeding duration had a negative predictive effect on the BMI percentile scores. ConclusionInattention, oppositionality and breast-feeding duration were associated with overweight/obesity in children and adolescents with ADHD. Longitudinal studies are needed to more fully understand this relationship and the mechanisms underlying the association between ADHD and overweight/obesity.Öğe Altered kynurenine pathway metabolite levels in toddlers and preschool children with autism spectrum disorder(Taylor & Francis Ltd, 2022) Bilgic, Ayhan; Abusoglu, Sedat; Sadic celikkol, Cagla; Oflaz, Mehmet Burhan; Akca, Omer Faruk; Sivrikaya, Abdullah; Baysal, TamerAim There are increasing reports about the potential role of kynurenine pathway metabolites in autism spectrum disorder (ASD). Early childhood is a very crucial period of time for the etiopathogenesis of ASD and previous studies reported an age-dependent alteration in kynurenine metabolism. However, no study specifically examined kynurenine metabolites in very young children with ASD. This study aimed to investigate kynurenine pathway metabolite levels, kynurenine pathway enzyme activities and neuroprotective index (kynurenic acid/3-hydroxykynurenine ratio) in toddlers and preschool children with ASD. Materials and Methods A total of 68 children with ASD and 44 healthy controls aged between 18 and 60 months were included in this study. Serum levels of kynurenine pathway metabolites were determined by liquid chromatography-mass spectrometry/mass spectrometry system. Results Serum 3-hydroxykynurenine and kynurenic acid concentrations were significantly higher in the ASD group than in the control group, whereas serum 3-hydroxyanthranilic acid concentrations were significantly lower. Conclusions These findings showed that the kynurenine pathway may play a role in the etiopathogenesis of ASD in early childhood.Öğe Association between endocrinological, immunological and psychosocial variables in psoriasis patients(Edizioni Minerva Medica, 2016) Bilgic, Ozlem; Bilgic, Ayhan; Sivrikaya, Abdullah; Selvi, Yavuz; Unlu, Ali; Altinyazar, Hilmi C.BACKGROUND: There is limited data concerning the relationship between psychosocial problems of psoriasis patients and the function of their hypothalamic-pituitary-adrenal (IPA) axis and immunologic markers. This study aimed to determine serum levels of basal cortisol and adrenocorticotropic hormone (ACTH) and circulating levels of various cytokines and chemokines and their association with psychological measures in psoriasis patients. METHODS: Serum concentrations of endocrinological and immunological variables were quantified, and psychiatric questionnaires were completed. RESULTS: In psoriasis patients, serum levels of ACTH, TNF-a, IL-6, IL-23, CCL-17, CCL-27, CCL-20 and CXCL-9, current psychiatric symptoms and childhood neglect scores were all higher than in controls. In addition, in psoriasis patients, physical neglect scores were related to lower basal cortisol, whereas recent stressful life events were related to higher IL-6, IL-23 and CCL-20 levels. CONCLUSIONS: The exposure to stressful life events in childhood and just before a flare-up of psoriasis may be related to altered function of the HPA axis and an immune dysregulation in psoriasis.Öğe Association of Reactive-Proactive Aggression and Anxiety Sensitivity with Internalizing and Externalizing Symptoms in Children with Attention-Deficit/Hyperactivity Disorder(Springer, 2017) Bilgic, Ayhan; Tufan, Ali Evren; Yilmaz, Savas; Ozcan, Ozlem; Ozmen, Sevgi; Oztop, Didem; Turkoglu, SerhatThis study evaluates the associations among the symptoms of anxiety, depression, and disruptive behavioral disorders (DBD) in the context of their relationships with reactive-proactive aggression and anxiety sensitivity in children with attention-deficit/hyperactivity disorder (ADHD). The sample consisted of 342 treatment-naive children with ADHD. The severity of ADHD and DBD symptoms were assessed via parent-and teacher-rated inventories. Anxiety sensitivity, reactive-proactive aggression and severity of anxiety and depression symp-toms of children were evaluated by self-report inventories. According to structural equation modeling, depression and anxiety scores had a relation with the DBD scores through reactive-proactive aggression. Results also showed a negative relation of the total scores of anxiety sensitivity on DBD scores, while conduct disorder scores had a positive relation with anxiety scores. This study suggests that examining the relations of reactive-proactive aggression and anxiety sensitivity with internalizing and externalizing disorders could be useful for understanding the link among these disorders in ADHD.Öğe Children with Migraine and Those with Tension-Type Headache for Psychiatric Symptoms and Quality of Life (vol 19, pg 14, 2021)(Georg Thieme Verlag Kg, 2021) Acikel, Sadettin Burak; Bilgic, Ayhan; Derin, Hatice; Eroglu, Arzu; Akca, Omer Faruk; Caksen, Huseyin[Abstract Not Availabe]Öğe Comparison of Children with Migraine and Those with Tension-Type Headache for Psychiatric Symptoms and Quality of Life(Georg Thieme Verlag Kg, 2021) Acikel, Burak Sadettin; Bilgic, Ayhan; Derin, Hatice; Eroglu, Arzu; Akca, Omer Faruk; Caksen, HuseyinThis study compared the severity of depression, anxiety, somatization, anxiety sensitivity, sleep disturbances, and quality of life (QoL) among children with migraine, children with tension-type headache (TTH), and healthy children. A total of 37 children with migraine, 22 with TTH, and a healthy control group (n =35) participated in this study. Children with migraine exhibited higher depression and somatization and lower QoL scores than those in the control group. General sleep disturbances, bedtime resistance, sleep onset delay, sleep duration, sleep anxiety, night wakings, sleep-disordered breathing, and daytime sleepiness scores were also higher in those in the migraine group than in the control group. Regression models indicated that the severity of headache and depression scores significantly affected the QoLs of children with headache disorder as a whole. Migraine is associated with depression, somatization, sleep disturbances, and poor QoL, whereas TTH is associated with only sleep disturbances in childhood. The impact of headache on the QoL occurs mainly through the headache-specific and psychiatric factors.Öğe Coprolalia Successfully Treated With Aripiprazole in a Child With Tourette Syndrome(Lippincott Williams & Wilkins, 2019) Saglam, Ebru; Bilgic, Ayhan[Abstract Not Availabe]Öğe Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder(Springer, 2018) Sivri, Rukiye Colak; Bilgic, Ayhan; Kilinc, IbrahimThe aim of this study was to investigate whether the serum levels of IL-12, IL-17, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF are associated with obsessive-compulsive disorder (OCD) in medication-free children. A total of 44 (22 boys/22 girls) medication-free children with OCD and 40 (23 boys/17 girls) healthy controls were included in this study. The severity of the OCD symptoms were assessed by the Children's Yale-Brown Obsessive-Compulsive Scale and the Maudsley Obsessive-Compulsive Inventory. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were applied to the children in order to determine depression and anxiety levels. IL-17, IL-12, TGF beta, TNF-alpha, sTNFR1, sTNFR2, IL-1 beta, CCL3, CCL24, CXCL8, and BDNF levels were measured by enzyme-linked immunosorbent assay. Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on both groups for the levels of serum cytokine, chemokine, and BDNF, an effect that was independent of severities of depression and anxiety [Pillai's Trace V = 0.371, F (11, 70) = 3.756, p < 0.001, hp(2) = 0.187]. Analysis of covariance (ANCOVA) indicated that serum TNF-alpha levels were significantly higher in the OCD group than in the control group (p < 0.001). In contrast, serum IL-12 levels were significantly lower in the OCD group than in the control group (p = 0.014). These findings suggest that TNF-alpha and IL-12 may play a role in the pathophysiology of OCD in children. The causal relationship between these proinflammatory cytokines and pediatric OCD requires further investigation.Öğe Decreased plasma intercellular adhesion molecule-3 levels are associated with obsessive compulsive disorder in medication-free children(Elsevier, 2020) Bilgic, Ayhan; Ileri, Betul Akbas; Kilinc, Ibrahim; Akca, Omer FarukThe objective of this study was to evaluate whether the plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), intercellular adhesion molecule-3 (sICAM-3), vascular cell adhesion molecule-1 (sVCAM-1), and/or platelet endothelial cell adhesion molecule-1 (sPECAM-1) were associated with obsessive compulsive disorder (OCD) in childhood. A total of 42 (25 boys, 17 girls) medication-free children with OCD and 38 (18 boys, 20 girls) healthy controls aged 8-18 years were included in the study. The severity of the OCD symptoms was assessed using the Children's Yale-Brown Obsessive Compulsive Scale. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were used to measure the children's depression and anxiety levels. The sICAM-1, sICAM-3, sVCAM-1, and sPECAM-1 concentrations were measured using an enzyme-linked immunosorbent assay. A multivariate analysis of covariance revealed a significant main effect on both groups in terms of the concentrations of plasma adhesion molecules, which was independent of the severities of depression and anxiety, body mass index percentile, age, and sex. An analysis of covariance showed that plasma sICAM-3 concentrations were significantly lower in the OCD group than in the control group. These data suggest that sICAM-3 may play a role in the etiopathogenesis of OCD in children.Öğe Diagnostic Video of Infantile Masturbation(Georg Thieme Verlag Kg, 2019) Sertdemir, Merve; Bilgic, AyhanIn this case report, the presentation and diagnosis of infantile masturbation by home video footage in a 12-month-old girl are discussed.Öğe Effect of adenotonsillectomy on sleep problems, attention deficit hyperactivity disorder symptoms, and quality of life of children with adenotonsillar hypertrophy and sleep-disordered breathing(Sage Publications Inc, 2019) Turkoglu, Serhat; Somuk, Battal Tahsin; Sapmaz, Emrah; Bilgic, AyhanObjective Chronic adenotonsillar hypertrophy is the most common etiologic reason for upper airway obstruction in childhood and has been found to be associated with a variety of psychiatric disorders and poor quality of life. In the present study, we investigated the impact of adenotonsillectomy on attention deficit hyperactivity disorder symptoms, sleep problems, and quality of life in children with chronic adenotonsillar hypertrophy. Methods The parents of children with chronic adenotonsillar hypertrophy filled out the Conners's Parent Rating Scale-Revised Short form (CPRS-RS), Children's Sleep Habits Questionnaire (CSHQ), and Pediatric Quality of Life Inventory, Parent version (PedsQL-P) before and six months after adenotonsillectomy. Results A total of 64 children were included in the study (mean age = 6.8 +/- 2.4 years; boy:girl ratio= 1). The mean attention deficit hyperactivity disorder index and oppositionality subdomain scores of the CPRS-RS and all of the CSHQ subdomain scores (bedtime resistance, sleep-onset delay, sleep anxiety, night waking, parasomnias, sleep-disordered breathing, and daytime sleepiness) except for sleep duration significantly decreased after adenotonsillectomy (p < 0.05). The PedsQL-P total score and both PedsQL-P physical health and psychosocial health subdomain scores were significantly higher at six months after adenotonsillectomy (p < 0.001). Conclusions Child and adolescent psychiatrists should check the symptoms of chronic adenotonsillar hypertrophy to identify children with chronic adenotonsillar hypertrophy who suffer from sleep disturbance, attention deficit hyperactivity disorder symptoms, and oppositionality. Adenotonsillectomy seems to be beneficial for coexisting attention deficit hyperactivity disorder and sleep disorder symptoms and quality of life in these children.Öğe The Effect of Clonazepam on Sleep Terror and Co-Occuring Nocturnal Enuresis in an Adolescent(Mary Ann Liebert, Inc, 2016) Acikel, Sadettin Burak; Bilgic, Ayhan[Abstract Not Availabe]Öğe Effect of OROS methylphenidate on encopresis in children with ADHD: a retrospective chart review(Springer, 2013) Yilmaz, Savas; Bilgic, Ayhan; Herguner, Sabri[Abstract Not Availabe]Öğe Effect of OROS Methylphenidate on Encopresis in Children with Attention-Deficit/Hyperactivity Disorder(Mary Ann Liebert, Inc, 2014) Yilmaz, Savas; Bilgic, Ayhan; Herguner, SabriObjectives: Although encopresis shows a high rate of comorbidity in patients with attention-deficit/hyperactivity disorder (ADHD), the etiologic origin of this relationship and the effect of ADHD drugs on encopresis are unclear. In this chart review, we explored the effect of OROS long-acting methylphenidate (MPH) treatment on encopresis in children with ADHD. We also evaluated the relationship between the clinical variables of ADHD and encopresis. Methods: The sample consisted of 21 children and adolescents (20 boys and 1 girl) with encopresis and coexisting ADHD 7-15 years of age. Their clinical characteristics and baseline (visit 1) and end of the second months' (visit 2) Conners' Parent Rating Scale (CPRS) subscores were recorded. Retrospective clinician determinations were made using the Clinical Global Impressions-Severity subscale (CGI-S) for encopresis severity and the Clinical Global Impressions-Improvement subscale (CGI-I) for encopresis response. Results: According to the CGI-I, 14 subjects (71.4 %) showed much or very much improvement in their encopresis at the second visit. All of the CPRS scores showed a significant reduction during the second visit. No association was found between the CGI-I score and the changes in any of the CPRS scores. Baseline oppositional defiant disorder (ODD) and conduct disorder (CD) scores were correlated with the CGI-S score; however, no association was found between core ADHD symptom severity and the CGI-S score. With regard to the encopresis outcome, the baseline CD score was negatively correlated with the CGI-I score, and the baseline ODD score was prone to show a negative correlation with the CGI-I score. Conclusions: These results suggest that coexisting behavioral problems may be a vulnerability factor based on the severity of encopresis, and that MPH treatment may have a positive effect on encopresis in children and adolescents with ADHD.Öğe Effectiveness of Atomoxetine in the Treatment of Children With Encopresis(Lippincott Williams & Wilkins, 2015) Turkoglu, Serhat; Bilgic, Ayhan; Uzun, Necati[Abstract Not Availabe]Öğe Evaluation of Appetite-Regulating Hormones in Young Children with Autism Spectrum Disorder(Springer/Plenum Publishers, 2021) Sadic, Cagla Celikkol; Bilgic, Ayhan; Kilinc, Ibrahim; Oflaz, Mehmet Burhan; Baysal, TamerThis study aimed to investigate the role of leptin, ghrelin, neuropeptide Y, and nesfatin-1 in young children with autism spectrum disorder (ASD). A total of 44 children with ASD and 44 healthy controls aged 18-60 months were included. Plasma levels of hormones were measured using commercial enzyme-linked immunosorbent assay kits. Plasma leptin and ghrelin levels were significantly higher in the ASD group than in the control group. However, no significant difference for plasma neuropeptide Y and nesfatin-1 levels was detected between the groups. No relation was found between the severity of ASD symptoms, severity of eating problems, and plasma levels of hormones. Leptin and ghrelin may play a potential role in the pathogenesis of ASD.Öğe Excessive Masturbation Successfully Treated with Fluoxetine in an Adolescent with Autism Spectrum Disorder and Coexisting Depression(Mary Ann Liebert, Inc, 2018) Celikkol, Cagla; Bilgic, Ayhan[Abstract Not Availabe]Öğe Excessive Masturbation Successfully Treated With Methylphenidate in a 6-Year-Old Child With Autism Spectrum Disorder Accompanied by Attention Deficit Hyperactivity Disorder(Lippincott Williams & Wilkins, 2021) Ferahkaya, Hursit; Bilgic, AyhanChildren with autism spectrum disorder frequently exhibit inappropriate sexual behaviors, such as excessive masturbation. However, research on the control and management of excessive masturbation in these children is very limited. In this presentation, excessive masturbation that responded to treatment with methylphenidate is described in a young boy diagnosed with autism spectrum disorder and comorbid attention deficit hyperactivity disorder.Öğe Exploratory study to evaluate plasma vasopressin and apelin-13 levels in children with attention-deficit hyperactivity disorder(Wiley, 2016) Bilgic, Ayhan; Toker, Aysun; Uysal, SalihaAimVasopressin exerts robust influences on social communication and behavior in humans. Apelin is a relatively novel neuropeptide that could counteract vasopressin's actions and has been shown to be closely related with a broad range of physiological functions. Abnormalities in vasopressin and apelin have been detected in a variety of psychiatric disorders, but their relation to attention-deficit hyperactivity disorder (ADHD) is unknown. In the present study, we explored the plasma levels of vasopressin and apelin-13 in children with ADHD. MethodsThirty-four children with ADHD and 36 healthy controls were enrolled in this study. The severity of ADHD symptoms was assessed via Conners' Parent Rating Scale and Conners' Teacher Rating Scale. Plasma levels of vasopressin and apelin-13 were measured using commercial enzyme-linked immunosorbent assay kits. ResultsThe mean plasma apelin-13 levels were significantly higher in male children with ADHD than in male control subjects; no significant difference was found between the groups for plasma apelin-13 levels in girls or in the entire subject cohort. Plasma vasopressin levels did not show any significant differences between groups. There were no significant correlations between plasma levels of these neuropeptides and scores for Conners' Parent Rating Scale and Conners' Teacher Rating Scale. ConclusionOur results suggest a sex-specific association between plasma apelin-13 levels and ADHD. Apelin-13 may play a role in the etiopathogenesis of ADHD either with a direct impact on the apelin receptor or via its opposing effect on the vasopressinergic system.
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