Yazar "Cakir-Koc, Rabia" seçeneğine göre listele

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    Green synthesis of silver nanoparticles using Thymbra spicata L. var. spicata (zahter) aqueous leaf extract and evaluation of their morphology-dependent antibacterial and cytotoxic activity
    (Taylor & Francis Ltd, 2018) Erci, Fatih; Cakir-Koc, Rabia; Isildak, Ibrahim
    Silver (Ag) nanoparticles (NPs) were green synthesized at room temperature using different concentrations of the Thymbra spicata L. var. spicata (Zahter) aqueous leaf extracts for the first time. With the synthesis of AgNPs using the leaf extract of Cynara scolymus (Artichoke) and Mentha piperita (Peppermint), the biological activities of the nanoparticles synthesized using leaf extract of three economically significant plants have been studied comparatively. Nanoparticles were characterized by different spectroscopic and microscopic analysis. TEM analysis of the biosynthesized AgNPs revealed that the size and shape of the AgNPs were changed with the plant extract concentration. Biologically synthesized AgNPs from leaf extracts of the three different plants displayed significant differences in antibacterial activity against two different gram-negative and gram-positive bacteria. Also, the results from this study show the shape dependence of the antibacterial and cytotoxic activity of silver nanoparticles synthesized using T. spicata leaf extract. The nanoparticles with different shapes exhibited the strongest antibacterial and cytotoxic activity compared to mostly spherical nanoparticles. Present results clearly indicate that biological activities of silver nanoparticles were affected by nanoparticle shape and the source of the plant extract used in the synthesis.
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    Microwave-irradiated green synthesis of metallic silver and copper nanoparticles using fresh ginger (Zingiber officinale) rhizome extract and evaluation of their antibacterial potentials and cytotoxicity
    (Taylor & Francis Inc, 2021) Jahan, Israt; Erci, Fatih; Cakir-Koc, Rabia; Isildak, Ibrahim
    Herein the microwave-assisted green synthesis of both silver (Ag) and copper (Cu) nanoparticles (NPs) by microwave irradiation have been successfully carried out using fresh ginger rhizome extract. Different analytical methods were used for the characterization of the nanoparticles. The size distribution of AgNPs was found from the range of 2.68 nm to 42.69 nm, whereas for CuNPs the size range was run from 11.32 nm to 33.70 nm in diameter. From the antibacterial assay, we found that both silver and copper nanoparticles demonstrated significant potentials against tested bacterial strains. Besides,in vitrocytotoxic effects of NPs were also tested on the L929 mouse fibroblast cell line through XTT cell viability assay which confirmed the non-toxic nature of AgNPs and CuNPs at all tested concentrations. Thus, the obtained biological properties, suggested the use of rhizome extract ofZingiber officinalemediated non-toxic AgNPs and CuNPs in further biomedical and clinical applications.
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    Rapid green synthesis of noncytotoxic iron oxide nanoparticles using aqueous leaf extract ofThymbra spicataand evaluation of their antibacterial, antibiofilm, and antioxidant activity
    (Taylor & Francis Inc, 2021) Erci, Fatih; Cakir-Koc, Rabia
    Herein the green synthesis of iron oxide (FeO) nanoparticles (NPs) was achieved by usingThymbra spicataleaf extract. The antibacterial activity of FeONPs was evaluated against both gram-positive and gram-negative bacteria by using broth microdilution assay. Further, the antioxidant and cytotoxic potential of FeONPs was determined by using standard protocols. The effects of nanoparticles onStaphylococcus aureusgrowth and on their biofilm formation were investigated. FeONPs at the concentration of 100 mu g/mL exhibited excellent bactericidal action againstSalmonella typhimurium. Also, the biogenic nanoparticles inhibited the growth rate ofS. aureus.Furthermore, FeONPs showed noncytotoxic characteristics on L929 mouse fibroblast cells. All these results revealed that FeONPs obtained by simple and eco-friendly synthesis process throughT. spicataextract could be considered a promising candidate as antibacterial agent for many different applications. Also, biogenic FeONPs with their antibiofilm activity onS. aureuscould serve as potent antibacterial agents against pathogenic biofilm-forming bacteria.
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    Synthesis of biologically active copper oxide nanoparticles as promising novel antibacterial-antibiofilm agents
    (Taylor & Francis Inc, 2020) Erci, Fatih; Cakir-Koc, Rabia; Yontem, Mustafa; Torlak, Emrah
    In this study, we aimed to synthesize copper oxide nanoparticles (CuONPs) mediated by plant extract in an environmentally friendly way and to reveal their potential biological activities. Here we synthesized CuONPs by using different concentrations of aqueous leaf extract of Thymbra spicata at 80 degrees C to obtain Ts1CuONPs and Ts2CuONPs. Biosynthesized nanoparticles were characterized by using UV-Vis, AFM, FTIR, SEM-EDS, TEM, DLS and zeta potential analysis. The antibacterial activity of the nanoparticles was determined by calculation of the inhibition zone and minimum inhibitory concentration against selected bacterial strains. Moreover, the antioxidant activity of the as-synthesized nanoparticles was evaluated based on DPPH radical scavenging activity. The results indicate that the as-synthesized NPs have an average size of 26.8 and 21 nm for Ts1CuONPs and Ts2CuONPs, respectively. The formed CuONPs have more antibacterial action on gram-positive bacteria compared to gram-negative bacteria. In addition, CuONPs demonstrated good inhibition activity against biofilm formation of Staphylococcus aureus (S. aureus). Furthermore, the results showed that the smaller size of the CuONPs caused the higher cytotoxicity on L929 mouse fibroblast cells. The as-synthesized CuONPs exhibit antibacterial and antibiofilm potential against S. aureus, indicating that they may be attractive candidates to use in future therapeutic applications.
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    Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
    (Biointerface Research Applied Chemistry, 2021) Kocabas, Erdal; Sariguney, Ahmet Burak; Erci, Fatih; Cakir-Koc, Rabia; Kocabas, Hilal Ozen; Torlak, Emrah; Coskun, Ahmet
    In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.