Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Biointerface Research Applied Chemistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.
Açıklama
Anahtar Kelimeler
Thiazole, Pyrrolidine, Antibacterial Activity, Cytotoxicity
Kaynak
Biointerface Research In Applied Chemistry
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
11
Sayı
4
