Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives

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dc.contributor.authorKocabas, Erdal
dc.contributor.authorSariguney, Ahmet Burak
dc.contributor.authorErci, Fatih
dc.contributor.authorCakir-Koc, Rabia
dc.contributor.authorKocabas, Hilal Ozen
dc.contributor.authorTorlak, Emrah
dc.contributor.authorCoskun, Ahmet
dc.date.accessioned2024-02-23T14:34:51Z
dc.date.available2024-02-23T14:34:51Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIn this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.en_US
dc.description.sponsorshipNecmettin Erbakan University Research Projects Board [171210015]en_US
dc.description.sponsorshipThis research was funded by Necmettin Erbakan University Research Projects Board, grant number 171210015.en_US
dc.identifier.doi10.33263/BRIAC114.1217812185
dc.identifier.endpage12185en_US
dc.identifier.issn2069-5837
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85100042653en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage12178en_US
dc.identifier.urihttps://doi.org/10.33263/BRIAC114.1217812185
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15761
dc.identifier.volume11en_US
dc.identifier.wosWOS:000606325300076en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBiointerface Research Applied Chemistryen_US
dc.relation.ispartofBiointerface Research In Applied Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiazoleen_US
dc.subjectPyrrolidineen_US
dc.subjectAntibacterial Activityen_US
dc.subjectCytotoxicityen_US
dc.titleSynthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivativesen_US
dc.typeArticleen_US

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