DSpace Arşivi :: by Yazar "Can, Ummugulsum" değerine göre listeleniyor

Yazar "Can, Ummugulsum" seçeneğine göre listele

Listeleniyor 1 - 15 / 15

Are decreased cocaine- and amphetamine regulated transcript and Agouti-related peptide levels associated Eating behavior in medication-free children with attention deficit and hyperactivity disorder?
(Pergamon-Elsevier Science Ltd, 2024) Tezcan, Mustafa Esad; Ugur, Cuneyt; Can, Ummugulsum; Ucak, Ekrem Furkan; Ekici, Fatih; Duymus, Fahrettin; Korucu, Agah Tugrul
This study aimed to investigate plasma levels of cocaine-and amphetamine-regulated transcript (CART), agouti-related protein (AgRP), cholecystokinin (CCK) and peptide YY (PYY) and their relationship with eating behaviors among children with attention deficit hyperactivity disorder (ADHD) and healthy controls. A total of 94 medication-free children with ADHD and 82 controls aged 8-14 years were included in this study. The Plasma levels of CART, AgRP, CCK and PYY were measured using enzyme-linked immunosorbent assay kits. The Chil-dren's Eating Behavior Questionnaire (CEBQ) was used to assess eating behaviors in children. CART and AgRP levels were found to be significantly lower in the ADHD group than in the control group, while CCK levels were found to be significantly higher in the ADHD group than in the control group. However, there was no significant difference in PYY levels between the groups. Compared to controls, those with ADHD demonstrated significantly higher scores on the CEBQ subscales of food responsiveness, emotional overeating, desire to drink, enjoyment of food, and food fussiness, and significantly lower scores on the slowness of eating subscale. CART was signifi-cantly correlated with emotional overeating and enjoyment of food scores, while AgRP was significantly correlated with emotional undereating scores. Covariance analysis was performed by controlling potential confounders such as body mass index, age and sex, and the results were found to be unchanged. It was concluded that CART, AgRP, and CCK may play a potential role in the pathogenesis of ADHD.
Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis
(Springer, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Yerlikaya, Fatma Humeyra; Aslan, Uysaler; Hidayetoglu, Bahauddin Taha
Oxidative stress results from either overproduction of free radicals or insufficiency of several antioxidant defense systems. It leads to oxidation of main cellular macromolecules and a resultant molecular dysfunction. Thyroid hormones regulate oxidative metabolism and, thus, play a role in free radical production. Studies evaluating oxidative stress in patients with hypothyroidism and hyperthyroidism have been encountered in recent years; however, oxidative status in patients with euthyroid autoimmune thyroiditis (AIT) was not investigated previously. Thirty-five subjects with euthyroid AIT and 35 healthy controls were enrolled in the study. Serum oxidative status was determined by the measurement of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and oxidized-low density lipoprotein (ox-LDL) levels. Serum TAS levels were significantly lower (p < 0.001), while serum TOS levels and IMA levels were significantly higher (p < 0.001 and p = 0.020, respectively) in patients compared to controls. In both groups, ox-LDL levels were similar (p = 0.608). Serum TAS levels were negatively correlated with antithyroid peroxidase and anti-thyroglobulin (anti-TG) levels (rho = -0.415, p = 0.001 and rho = -0.484, p < 0.001, respectively). Serum TOS was positively correlated with anti-TG levels (rho = 0.547, p < 0.001). Further, TAS was positively correlated with free T4 levels (r = 0.279, p = 0.043). No correlation was observed between thyrotropin, free T3 levels, and TOS and TAS levels. These results suggest that oxidants are increased, and anti-oxidants are decreased in patients with euthyroid AIT, and oxidative/anti-oxidative balance is shifted to the oxidative side. Increased oxidative stress might have a role in thyroid autoimmunity.
Can YKL-40 be an Inflammatory Biomarker in Vitamin D Deficiency?
(Verlag Hans Huber, 2019) Can, Ummugulsum; Uysal, Saliha; Ugur, Ayse Ruveyda; Toker, Aysun; Aslan, Uysaler; Hidayetoglu, Bahauddin Taha
Vitamin D deficiency is associated with several non-homeostatic conditions and/or diseases like inflammation, atherosclerosis, cardiovascular disease and mortality. YKL-40 is a glycoprotein, secreted by macrophages, neutrophils and different cell types and it is also associated with inflammation and pathological tissue remodeling. In this study, we aimed to evaluate relationship between the proinflammatory biomarkers YKL-40 and hs-CRP levels and vitamin D deficiency. Our study group includes 45 subjects with vitamin D deficiency (Group 1) (20 M, 25 F; mean age 37.72 +/- 7.70 years) and 40 age and sex-matched healthy subjects with normal serum levels of vitamin D (Group 2) (19 M, 21 F; mean age 39.26 +/- 7.41 years). Plasma 25 (OH) vitamin D levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. Plasma YKL-40 analysis was performed by ELISA. Serum hs-CRP levels were measured by nephelometric method. Plasma vitamin D levels below 20 ng/mL were accepted as vitamin D deficiency. Although we could not find any significant differences by means of serum hs-CRP levels between Group 1 and Group 2 (2.21 (0.27-11.70); 1.79 (0.16-9.85) mg/L, p = 0.247), plasma YKL-40 levels were significantly higher in group 1 than group2 (70.47 (17.84-198.50); 47.14 (4.80-135.48) ng/mL, p = 0.047). In literature, vitamin D deficiency is associated with inflammation. In our study, we found similar hs-CRP levels between groups and higher YKL-40 levels in group 1. Vitamin D deficiency may be related to high YKL-40 levels in terms of causing chronic inflammation.
THE EFFECT OF ENVIRONMENTAL ENRICHMENT AND WESTERN DIET ON THE TRACE ELEMENT STATUS AND OXIDATIVE STRESS IN RATS
(Nobel Ilac, 2020) Can, Ummugulsum; Yerlikaya, Fatma Humeyra; Oz, Mehmet; Atalik, Kismet Esra Nurullahoglu; Gergerlioglu, Hasan Serdar
Objective:The Western diet (WD), which is rich in highfat diet (HFD) and high-sucrose diet (HSD), is related to oxidative stress. Enriched environment (EE) with social interaction, physical exercise and continuous learning tasks has been shown to reduce oxidative stress, the inflammatory response, and increase the anti-oxidative defense. Therefore, the present study has aimed to clarify the effects of the EE and WD-fed rats on marker malondialdehyde (MDA) and trace element (TE) levels (iron [Fe], copper [Cu], zinc [Zn], chromium [Cr], selenium [Se], magnesium [Mg] and molybdenum [Mo]). Material and Method: Male Wistar albino rats were housed in either an enrichment (n=24) or standard environment (n=24) and fed with HFD (35% of energy as fat) (n=8), HSD (100% of carbohydrate as sucrose) (n=8), or standard rat chow(n=8), for 4 weeks. Inductively-coupled plasma mass spectrometry was used for determination of the serum TE levels. Results: The serum levels of MDA (p<0.05), Fe, Cu, Mo and Mg increased, while the serum levels of Cr and Se decreased, and additionally, the serum levels of Zn did not changed in the HFD and HSD groups. EE decreased partially the serum levels of MDA, Fe, Mo, and did not affect the serum levels of Cu, while it increased the serum levels of Mg, Cr, Se and Zn; however, there was no significant difference between all of the experimental groups (all; p>0.05). Conclusions: Our study demonstrated that HFD and HSD led to oxidative stress and adversely affected the serum level of TE in rats, and that the EE reversed partially this status.
Evaluation of oxidant/anti-oxidants status in patients with mild acute pancreatitis
(Univ Catholique Louvain-Ucl, 2016) Baser, Husniye; Can, Ummugulsum; Karasoy, Deniz; Ay, Abdulhalim Serden; Baser, Salih; Yerlikaya, Fatma Humeyra; Ecirli, Samil
Background and aim : Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to involve high oxidative stress (OS), combined with inadequate antioxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified albumin (IMA) in patients with mild AP. Methods : Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, Creactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrinogen were measured in both groups. Results : TAS levels were significantly lower (p = 0.037), while IMA levels were significantly higher (p < 0.001) in patients, compared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (p < 0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (r = 0.448, p = 0.001 and r = 0.469, p < 0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (r = -0.277, p = 0.035 and r = -0.278, p = 0.034, respectively). Conclusions : OS is reported to be associated with the inflammatory process and the severity of AP. In our study, among OS parameters, an increase in IMA levels and a decrease in TAS levels were observed in mild AP patients.
Impact of Continuous Positive Airway Pressure Treatment on Leptin Levels in Patients with Obstructive Sleep Apnea Syndrome
(Mary Ann Liebert, Inc, 2015) Yosunkaya, Sebnem; Okur, Hacer Kuzu; Can, Ummugulsum; Zamani, Adil; Kutlu, Ruhusen
Background: There is growing evidence that leptin regulation is altered in obstructive sleep apnea syndrome (OSAS). Several potential mechanisms have been purported to explain how sleep apnea may alter leptin levels. We investigated whether repeated apneas, hypoxia, or excessive daytime sleepiness influenced the levels of leptin in OSAS patients. We also evaluated whether a 3-month continuous positive airway pressure (CPAP) treatment affected leptin levels in patients. Methods: Randomly selected 31 untreated, otherwise healthy male, overweight [body mass index (BMI) >25kg/m(2)] obstructive sleep apnea syndrome (OSAS) patients [apnea-hypopnea index (AHI) 15] and 25 control (AHI <5) were included in this study. To confirm the diagnosis, all subjects underwent standard polysomnography. Serum samples were taken at 07:00-08:00 a.m. after overnight fasting. The OSAS patients that had regular CPAP treatment (n=26) were re-evaulated 3 months later. Results: Leptin levels (50.517.5 grams/L in OSAS and 56.3 +/- 25.5 grams/L in controls) and lipid profiles (TC, TGs, HDL-C, and LDL-C) between patient and control groups did not differ (P>0.05). Leptin levels were not correlated with the AHI, oxygen saturation, or excessive daytime sleepiness. CPAP treatment did not significantly change the (BMI), waist and neck circumference, or leptin levels in OSAS patients. Furthermore, we found no correlation between the decrease in serum leptin levels and parameters that were improved by CPAP treatment. Conclusion: Leptin levels and lipid profile of overweight subjects with and without OSAS were not different, and our results suggest that OSAS-related parameters and CPAP treatment do not play a significant role in the serum leptin levels.
The investigation of levels of endothelial cell-specific molecule, progranuline, clusterin, and human epididymis protein 4 in the differential diagnosis of malignant pleural effusions
(Lippincott Williams & Wilkins, 2022) Demirbas, Soner; Yerlikaya, Fatma Humeyra; Yosunkaya, Sebnem; Can, Ummugulsum; Celalettin, Korkmaz
Background:Progranulin (PGRN), endothelial cell-specific molecule-1, clusterin (CLU), and human epididymis protein 4 (HE-4) are novel proteins reported to have diagnostic and prognostic potential in lung cancer. Here, we aimed to identify the markers with high sensitivity and specificity in distinguishing malignant pleural fluids from other pleural fluids. Methods:This prospective, descriptive study was conducted at a medical faculty hospital between 2016 and 2019. The study population consisted of 90 patients <18 years of age with pleural effusion (PE). Levels of pleural fluids of PGRN, endothelial cell-specific molecule-1, CLU, and HE-4 were measured with enzyme-linked immunosorbent assay kits under the manufacturer's manual. Results:Of 90 patients, 54 were men, and 36 were women (mean age 65 +/- 16 years). Of pleural fluids investigated, 23 (25%) and 67 (74%) were transudates and exudates, respectively. Of exudates, while 27 (40%) and 19 (28%) were parapneumonic PE and tuberculous PE, respectively, 20 (29%) were malignant pleural effusion (MPE). Levels of all biomarkers in exudate fluids were found significantly higher than those of transudate fluids. CLU, HE-4, and PGRN levels in MPE were also found significantly higher than benign fluids (P < .05). Cutoff values were achieved by receiver operating characteristics analysis for CLU, HE-4, and PGRN to distinguish between malignant and benign groups. For diagnosis of MPE, the sensitivity and specificity values were found as 0.66 and 0.67 for a cutoff value of CLU of 18.29 mg/L (P = .00), as 0.76 and 0.76 for a cutoff value of HE-4 of 9.33 mg/L (P = .00), and as 0.66 and 0.67 for a cutoff value of PGRN of 105.91 mg/L (P = .001). Conclusion:HE-4 having high sensitivity and specificity can be a potential diagnostic marker in distinguishing between malignant and benign effusions, and these findings can constitute a basis for future research.
Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
(Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
Investigation of the inflammatory biomarkers of metabolic syndrome in adolescents
(Walter De Gruyter Gmbh, 2016) Can, Ummugulsum; Buyukinan, Muammer; Guzelant, Asuman; Ugur, Ayse; Karaibrahimoglu, Adnan; Yabanciun, Sukriye
Background: Metabolic syndrome (MetS) is a chronic and multifactorial syndrome characterized by a low-grade chronic inflammation, and a major risk factor for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). In our study, we aimed to investigate the serum levels of high sensitive C-reactive protein (hs-CRP), haptoglobin (Hp), alpha(2)-macroglobulin (alpha(2)-MG), platelet factor-4 (PF-4), fetuin-A, serum amyloid P (SAP) and alpha(1)-acid glycoprotein (AGP) in an adolescent population with MetS. Methods: This study was performed in 43 (18 males, 25 females) MetS adolescents between the ages of 13 and 17 years (14.70 +/- 1.15) and 43 lean controls were matched for age and sex. The serum levels of Hp, alpha(2)-MG, PF-4, fetuin-A, SAP and AGP were measured by using a multi-ELISA technique. Results: Serum Hp, fetuin-A (p < 0.01) and PF-4, hs-CRP, SAP, AGP (p < 0.001) values of the MetS subjects were significantly higher than those of the controls. No difference was found in serum alpha(2)-MG levels between the MetS and control groups (p = 0.184). Conclusions: This finding suggests the possibility of using these markers in diagnosis of MetS in adolescents to prevent future complications.
Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease
(Lippincott Williams & Wilkins, 2015) Can, Ummugulsum; Yerlikaya, Fatma Humeyra; Yosunkaya, Sebnem
Background: Chronic obstructive pulmonary disease (COPD) has been associated with increased oxidative stress or reduced antioxidant resources. The main goal of this study was to evaluate the levels of serum ischemia-modified albumin (IMA), oxidized low-density lipoprotein (ox-LDL), total oxidant status (TOS), and total antioxidant status in patients with stable COPD, compared with a control group. Methods: This study was performed on 51 patients with stable COPD (42 men and 9 women; mean age 56.92 +/- 3.0 years) and 45 healthy control participants (32 men and 13 women; 54.8 +/- 3.8 years). The levels of serum lipids, IMA, total antioxidant status, TOS, and ox-LDL were measured in all participants. Results: The levels of serum IMA, ox-LDL, and TOS were significantly higher in patients with COPD than those in control individuals. There was no difference between the levels of serum total antioxidant status, triglycerides, total cholesterol, and low-density lipoprotein cholesterol (LDL-C) of patients with COPD and those of control individuals. Serum high-density lipoprotein cholesterol levels were significantly lower in patients with COPD than in control individuals. Conclusion: Our study indicated that serum IMA, ox-LDL, and TOS may be increased as a result of chronic hypoxia, inflammation, and oxidative stress in patients with severe and very severe stable COPD. Our findings also revealed that IMA is higher in. patients with Global Initiative for Chronic Obstructive Lung Disease Stages II, III, and IV, while TOS and ox-LDL are higher in patients with Global Initiative for Chronic Obstructive Lung Disease Stage IV. Measurements of serum IMA, TOS, and ox-LDL levels may be useful markers in the evaluation of stable COPD. Copyright (C) 2015 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.
The Role of Serum Soluble Urokinase-Type Plasminogen Activator Receptor in Stable Chronic Obstructive Pulmonary Disease
(Bmj Publishing Group, 2014) Can, Ummugulsum; Guzelant, Asuman; Yerlikaya, Fatma Humeyra; Yosunkaya, Sebnem
Background: Chronic obstructive pulmonary disease (COPD) results from an abnormal inflammatory response of the lungs to noxious particles or gases. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is a glycoprotein secreted during infections and inflammation. The main goal of this study was to evaluate the serum suPAR level in stable COPD patients compared with a control group. Methods: Forty-six stable COPD patients and 41 control subjects were included in the study. Blood samples were collected from 46 stable COPD patients (40 men, 6 women; mean [SD] age, 55.92 [7.91] years; the forced expiratory volume in 1 second, 45.32% [19.1%] of predicted). Forty-one healthy subjects were selected as control subjects and were matched to COPD patients with respect to age and body mass index. Serum suPAR and plasma fibrinogen levels were measured in stable COPD patients and control subjects. Results: Serum suPAR levels of the COPD patients were significantly higher than those of the control subjects (4.94 [2.79] and 2.40 [2.01] ng/mL, respectively; P < 0.001). Plasma fibrinogen levels of the COPD patients were significantly higher than those of the control subjects (406.77 [172.6] and 336.53 [96.1] g/L, respectively; P < 0.05). Conclusions: Our study indicated that serum suPAR may play an important role in the inflammatory process of COPD, and this increase may be particularly large for patients in Global Initiative for Chronic Obstructive Lung Disease stages III and IV. Serum suPAR and plasma fibrinogen level measurements may be useful for the evaluation of stable COPD.
Serum levels of soluble urokinase plasminogen activator receptor as a new inflammatory marker in adolescent obesity
(Wolters Kluwer Medknow Publications, 2017) Can, Ummugulsum; Buyukinan, Muammer; Yerlikaya, Fatma Humeyra
Background & objectives: Obesity is known for low-grade inflammatory state with enhanced production of inflammatory mediators in children and adolescents. Soluble urokinase plasminogen activator receptor (suPAR) can be generated as a pro-inflammatory marker. This study was conducted to evaluate the role of suPAR, and its association with leptin, adiponectin, interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP) and fibrinogen in adolescent obesity. Methods: A total of 98 participants, 55 obese individuals and 43 healthy controls, aged between 10 and 17 yr, were included in the study. Serum suPAR, IL-6, leptin and adiponectin were measured using ELISA method. Results: Serum suPAR, IL-6, fibrinogen, hsCRP and leptin levels in obese individuals were significantly higher than those of controls (P < 0.05 & P < 0.001). Serum adiponectin levels in obese individuals were significantly lower than those of controls (P < 0.01). Interpretation & conclusions: Our findings showed that suPAR, IL-6, fibrinogen, hsCRP and leptin were significantly higher in the obese individuals than those of controls. suPAR may be a good novel biomarker for systemic subclinical inflammation and immune activation linked to adolescent obesity.
Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency
(Sbem-Soc Brasil Endocrinologia & Metabologia, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Hidayetoglu, Bahauddin Taha; Aslan, Uysaler; Buyuktorun, Ilker; Yerlikaya, Fatma Humeyra
Objective: Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D. Materials and methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D. Results: Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels. Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.
Serum total oxidant/anti-oxidant status, ischemia-modified albumin and oxidized-low density lipoprotein levels in patients with vitamin D deficiency
(Sbem-Soc Brasil Endocrinologia & Metabologia, 2015) Baser, Husniye; Can, Ummugulsum; Baser, Salih; Hidayetoglu, Bahauddin Taha; Aslan, Uysaler; Buyuktorun, Ilker; Yerlikaya, Fatma Humeyra
Objective: Oxidative damage may be responsible for the pathogenesis and complications of many diseases. Vitamin D deficiency has been suggested as a potential mediator of various extra-skeletal pathologies. However, there are limited data on anti-oxidant properties of vitamin D. Materials and methods: Forty-one subjects with vitamin D deficiency and 30 healthy controls were enrolled into the study. The levels of total anti-oxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), oxidized-low density lipoprotein (ox-LDL), high-sensitivity C-reactive protein (hs-CRP) and fibrinogen were measured in both groups. The measurements were repeated in 17 patients after the replacement of vitamin D. Results: Serum IMA and TOS levels were significantly higher (p < 0.001 and p = 0.035, respectively), while TAS levels were significantly lower in patients, compared to controls (p < 0.001). Additionally, fibrinogen was significantly higher in patients than controls (p = 0.003), while ox-LDL and hs-CRP levels were similar between two groups. After the replacement of vitamin D, TAS level significantly increased (p = 0.037), and TOS and fibrinogen levels significantly decreased (p = 0.043 and p = 0.010, respectively). Vitamin D levels were negatively correlated with IMA and fibrinogen levels (r = -0.500, p < 0.001 and r = -0.391, p = 0.002, respectively), although positively correlated with TAS levels (r = 0.430, p < 0.001). No correlation was found between vitamin D levels, and the TOS, ox-LDL and hs-CRP levels. Conclusions: In this study, while serum IMA, TOS and fibrinogen levels were increased, TAS levels were seen to be decreased in patients with vitamin D deficiency. These results suggest that oxidative/anti-oxidative balance shifts in favours of oxidative status in vitamin D deficiency.
SERUM UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE PANCREATITIS
(Nobel Ilac, 2021) Can, Ummugulsum; Baser, Salih; Yerlikaya, Fatma Humeyra; Karasoy, Deniz
Objective: Acute pancreatitis (AP) is an inflammatory disease in which digestive enzymes produced by pancreas destroy the gland via protease pancreatic au todigestion. Soluble urokinase-type plasminogen activator receptor (suPAR), an inflammatory biomarker, is responsible for various immunological functions, including inflammation, cell adhesion, migration and proteolysis. The main goal of our study was to evaluate serum suPAR level in patients with mild AP, compared with controls. Material and Method: The study was performed on 40 patients with mild AP and 50 healthy controls. Controls were matched with patients as to age and body mass index (BMI). The diagnosis of AP was established under the Ranson criteria. Serum suPAR levels were measured through ELISA method. Results: Serum suPAR levels of patients were significantly higher than those of control subjects (4.81 +/-.3.30; 1.98 +/- 1. 78 ng/ml, respectively) (p<0.001). No significant correlation was found between suPAR levels, amylase, lipase, CRP, hs-CRP and fibrinogen levels (p>0.05 for all parameters). Conclusion: Our study indicated that serum suPAR may play an important role in the inflammatory process in AP, and suPAR could be used as a clinically beneficial marker in the diagnosis of AP.

Yazar "Can, Ummugulsum" seçeneğine göre listele

Sayfa Başına Sonuç

Sıralama seçenekleri