SERUM UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE PANCREATITIS
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobel Ilac
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Acute pancreatitis (AP) is an inflammatory disease in which digestive enzymes produced by pancreas destroy the gland via protease pancreatic au todigestion. Soluble urokinase-type plasminogen activator receptor (suPAR), an inflammatory biomarker, is responsible for various immunological functions, including inflammation, cell adhesion, migration and proteolysis. The main goal of our study was to evaluate serum suPAR level in patients with mild AP, compared with controls. Material and Method: The study was performed on 40 patients with mild AP and 50 healthy controls. Controls were matched with patients as to age and body mass index (BMI). The diagnosis of AP was established under the Ranson criteria. Serum suPAR levels were measured through ELISA method. Results: Serum suPAR levels of patients were significantly higher than those of control subjects (4.81 +/-.3.30; 1.98 +/- 1. 78 ng/ml, respectively) (p<0.001). No significant correlation was found between suPAR levels, amylase, lipase, CRP, hs-CRP and fibrinogen levels (p>0.05 for all parameters). Conclusion: Our study indicated that serum suPAR may play an important role in the inflammatory process in AP, and suPAR could be used as a clinically beneficial marker in the diagnosis of AP.
Açıklama
Anahtar Kelimeler
Acute Pancreatitis, Soluble Urokinase-Type Plasminogen Activator Receptor, Inflammation
Kaynak
Nobel Medicus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
17
Sayı
1
