SERUM UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE PANCREATITIS

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dc.contributor.authorCan, Ummugulsum
dc.contributor.authorBaser, Salih
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorKarasoy, Deniz
dc.date.accessioned2024-02-23T14:49:27Z
dc.date.available2024-02-23T14:49:27Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective: Acute pancreatitis (AP) is an inflammatory disease in which digestive enzymes produced by pancreas destroy the gland via protease pancreatic au todigestion. Soluble urokinase-type plasminogen activator receptor (suPAR), an inflammatory biomarker, is responsible for various immunological functions, including inflammation, cell adhesion, migration and proteolysis. The main goal of our study was to evaluate serum suPAR level in patients with mild AP, compared with controls. Material and Method: The study was performed on 40 patients with mild AP and 50 healthy controls. Controls were matched with patients as to age and body mass index (BMI). The diagnosis of AP was established under the Ranson criteria. Serum suPAR levels were measured through ELISA method. Results: Serum suPAR levels of patients were significantly higher than those of control subjects (4.81 +/-.3.30; 1.98 +/- 1. 78 ng/ml, respectively) (p<0.001). No significant correlation was found between suPAR levels, amylase, lipase, CRP, hs-CRP and fibrinogen levels (p>0.05 for all parameters). Conclusion: Our study indicated that serum suPAR may play an important role in the inflammatory process in AP, and suPAR could be used as a clinically beneficial marker in the diagnosis of AP.en_US
dc.identifier.endpage53en_US
dc.identifier.issn1305-2381
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18192
dc.identifier.volume17en_US
dc.identifier.wosWOS:000648280400006en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherNobel Ilacen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectSoluble Urokinase-Type Plasminogen Activator Receptoren_US
dc.subjectInflammationen_US
dc.titleSERUM UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE PANCREATITISen_US
dc.typeArticleen_US

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