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    The Effects of Low Dose Zinc Supplementation on the Development of New Bone in Rabbits
    (Istanbul Training & Research Hospital, 2020) Calik, Mustafa; Calik, Saniye Goknil; Dagli, Mustafa; Avunduk, Mustafa Cihat
    Introduction: Zinc (Zn) is an essential element for the healthy bone metabolism. It promotes bone formation by stimulating the proliferation and differentiation of osteoblasts, and increases the stimulation of osteoblastic bone mineralisation. Also, it suppresses the differentiation of osteoclasts while inhibiting bone resorption. The purpose of this study is to investigate the effects of low-dose Zn supplementation on new bones grown in rabbits. Methods: We evaluated 40 male white rabbits aged six weeks from New Zealand in 8 groups, with each including 5 subjects. All the groups underwent subperichondrial costal cartilage resections from the third rib on the right hemithorax. Rabbits in first and second groups underwent the partial resection of two ribs, and rabbits in third and fourth groups underwent total rib resection. Rabbits in fifth and sixth groups underwent the partial resection of four ribs, whereas rabbits in seventh and eighth groups underwent total resection. Rabbits in Groups 2, 4, 6, and 8 were treated with 6 mg/kg/day intraperitoneal Zn for four weeks after the operation. All groups were followed up to the 24th week of their lives. Results: We detected a statistically significant difference for both osteoblasts and osteoclasts among all the subgroups. Additionally, we also detected a significant increase in bone consolidation by Zn supplementation. Our study found that Zn suppresses osteoblastic bone absorption by stimulating osteoblastic bone formation in the light of the literature. Conclusion: Low-dose Zn administration in rabbits has been found to expedite the rib consolidation. Zn can be used to increase the bone maturation such as at the site of new bone formation in rib fracture and after all kinds of operations related to bones.
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    Rib fractures: Could we accelerate the healing?
    (Bayrakol Medical Publisher, 2020) Calik, Mustafa; Calik, Saniye Goknil; Dagli, Mustafa; Avunduk, Mustafa Cihat
    Aim: We thought about How fractures are improving more rapidly. For this purpose, we made an experimental model to investigate the effect of zinc supplementation on the development of new bone in young rabbits. Material and Method: Six weeks of age, male New Zealand white rabbits were evaluated in four groups, each including five subjects. To simulate the RFs, subperichondrial costal cartilage resections beginning from the third costal cartilage were carried out in the right hemithorax according to groups. Rabbits in Group 1 and 2 underwent partial resection of the two ribs; rabbits in Group 3 and 4 underwent total resection of those. Zinc was administered by intraperitoneal injection of 6 mg/kg/ day for four weeks after the surgery for group 2 and 4. The animals were followed-up at the twenty-fourth week of their life. Results: We analyzed histologic changes in the bone. There were statistically significant differences for osteoblasts and osteoclasts among all subgroups. Histologic consolidation was significantly increased by zinc supplementation. According to the literature, in our study, while zinc stimulates osteoblastic bone formation, suppresses osteoclastic bone resorption. Discussion: Although the proper treatment of rib fracture (RF), long-term disability and persistent chest wall pain frequently develop and may take several months to recover, leads to the high hospital, medicine, labor, and social burden. Our findings indicate that zinc supplementation accelerates the consolidation of ribs. Zinc can be used to increase the bone maturation such as the site of new bone formation in RF.