Rib fractures: Could we accelerate the healing?
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: We thought about How fractures are improving more rapidly. For this purpose, we made an experimental model to investigate the effect of zinc supplementation on the development of new bone in young rabbits. Material and Method: Six weeks of age, male New Zealand white rabbits were evaluated in four groups, each including five subjects. To simulate the RFs, subperichondrial costal cartilage resections beginning from the third costal cartilage were carried out in the right hemithorax according to groups. Rabbits in Group 1 and 2 underwent partial resection of the two ribs; rabbits in Group 3 and 4 underwent total resection of those. Zinc was administered by intraperitoneal injection of 6 mg/kg/ day for four weeks after the surgery for group 2 and 4. The animals were followed-up at the twenty-fourth week of their life. Results: We analyzed histologic changes in the bone. There were statistically significant differences for osteoblasts and osteoclasts among all subgroups. Histologic consolidation was significantly increased by zinc supplementation. According to the literature, in our study, while zinc stimulates osteoblastic bone formation, suppresses osteoclastic bone resorption. Discussion: Although the proper treatment of rib fracture (RF), long-term disability and persistent chest wall pain frequently develop and may take several months to recover, leads to the high hospital, medicine, labor, and social burden. Our findings indicate that zinc supplementation accelerates the consolidation of ribs. Zinc can be used to increase the bone maturation such as the site of new bone formation in RF.
Açıklama
Anahtar Kelimeler
Zinc, Supplementation, Rib Fracture, Rabbits
Kaynak
Annals Of Clinical And Analytical Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
2
