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    Association of adverse outcomes of intrahepatic cholestasis of pregnancy with zonulin levels
    (Taylor & Francis Inc, 2021) Deniz, Cigdem Damla; Ozler, Sibel; Sayin, Fatma Kubra
    Our aim was to investigate serum zonulin levels in intrahepatic cholestasis of pregnancy (ICP) and to determine the usefulness of zonulin in ICP follow-up. A prospective case-control study was carried out which included 88 pregnant women (44 patients with ICP and 44 controls). Maternal serum samples obtained from all participants and zonulin levels were determined by enzyme-linked immunosorbent assay (ELISA). Compared with controls, women with ICP had significantly higher zonulin levels (mean 0.728 +/- 0.520 ng/mL vs. 1.303 +/- 0.63 ng/mL, p 001). According to the receiver operating characteristic (ROC) analysis performed for the predictive value of zonulin levels for ICP, the area under the curve (AUC) was 0.761 (95% CI: 0.661-0.860). Multivariable logistic regression analysis revealed serum zonulin levels was independently associated with adverse perinatal outcomes (OR = 1.278, 95% CI: 0.232-7.041), severity ICP (OR: 7.535, 95% CI: 1.597-13.553) and also unresponsiveness to treatment in ICP (OR: 4.178, 95% CI: 0.929-8.784). IMPACT STATEMENT What is already known on this subject? Zonulin is a regulator protein that increases the intestinal permeability by modulating the intercellular tight junctions (TJ). It is the only physiological protein known to control intestinal permeability and damage of the intestinal barrier is one of the causes of absorption disorders, inflammation and autoimmunity. ICP is a relatively non-threatening condition to women but is linked with a higher risk of preterm delivery, foetal distress and foetal death. What do the results of this study add? This study showed that increased levels of zonulin are associated with adverse perinatal outcomes, severity of ICP and unresponsiveness to treatment in ICP. What are the implications of these findings for clinical practice and/or further research? Focussing on preservation of intestinal permeability may be an alternative preventive strategy to reduce the adverse perinatal outcomes and severity of ICP. Further longitudinal studies are needed to verify the relationships among zonulin levels and pregnancy-related diseases.
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    Associations between Emotional Eating and Metabolic Risk Factors at Adolescents with Obesity
    (Lifescience Global, 2020) Sayin, Fatma Kubra; Buyukinan, Muammer; Deniz, Cigdem Damla; Arslan, Derya
    Purpose: This study aimed to determine whether emotional eating (EE) and uncontrolled eating (UCE) scores affect the metabolic risk factors in obese adolescents. Methods: A sample of 100 adolescents have BMI-SDS between 1.41 and 2.83 (aged 12-17 years) was selected. EE and UCE scores were estimated using the TFEQ21. The association of EE and UCE with anthropometric data, lipid profile, glucose profile, liver enzymes, and inflammation factors was assessed in boys and girls. Results: Using Spearman rank correlation, EE scores significantly correlated with uric acid (r = 0.393 and P = 0.001), CRP (r = 0.273 and P = 0.017), TG (r = 0.317 and P = 0.001), TC (r = 0.258 and P = 0.019) and VAI (r = 0.276 and P = 0.034). Also UCE scores were showed positive correlation with CRP (r = 0.257 and P = 0.024). Conclusion: In conclusion, interrelationships tend to exist between EE and triglyceride, uric acid, visceral adiposity index, and CRP levels among obese adolescents.
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    Associations between night eating syndrome and metabolic parameters in pregnant women
    (Galenos Yayincilik, 2019) Deniz, Cigdem Damla; Ozler, Sibel; Sayin, Fatma Kubra; Eryilmaz, Mehmet Ali
    Objective: In this study, we aimed to evaluate the incidence of night eating in pregnancy and the relationship between night eating scores and nutritional status, insulin resistance, and lipid profile in pregnant women. Materials and Methods: In this study, 148 pregnant women who presented to the Gynecology and Obstetrics Clinics at Konya Training and Research Hospital in Konya were divided into two groups according to their night eating scores. These two groups were compared in terms of their nutritional attitudes and metabolic parameters. Results: Comparisons of participants meeting night eating syndrome (NES) scores versus women without NES indicated that patients with NES exhibited fever hunger at breakfast time, more breakfast skipping (p<0.05) than those without NES. Also homeostatic model assessment insulin resistance, insulin, and high-density lipoprotein cholesterol parameters were significantly higher in pregnant women in the NES group (p<0.05). Also, correlations were found between higher night eating questionnaire total scores and higher HbA1c, insulin resistance, insulin, and more breakfast skipping. Conclusion: The results of this study suggest that night eating symptoms during pregnancy may increase and this is able to effect glucose metabolism.
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    Dynamic thiol disulphide homeostasis in operating theater personnel exposed to anesthetic gases
    (Wiley, 2017) Kozanhan, Betul; Inanli, Ikbal; Deniz, Cigdem Damla; Iyisoy, Mehmet Sinan; Neselioglu, Salim; Sahin, Osman; Akin, Fatma
    Background: The purpose of this study was to investigate the association between dynamic thiol/disulphide homeostasis and occupational exposure to volatile anesthetic gases in operating theater personnel. Decreased blood thiol levels and raised blood disulphide levels serve as biomarkers of oxidative stress. Methods: Weincluded 65 subjects occupationally exposed and 55 unexposed healthy medical professionals into the study. A novel method enabled separate measurements of components involved in dynamic thiol/disulphide homeostasis (native thiol, disulphide, and total thiol). To control for the potential confounding effect on oxidative stress of psychological symptoms potentially caused by occupational stress, we used scores obtained from four different anxiety and depression inventories. Results: Mean +/- standard deviation native thiol was found to be 433.35 +/- 30.68 in the exposed group, lower than among controls, 446.61 +/- 27.8 (P = 0.02). Disulphide in the exposed group was 15.78 +/- 5.12, higher than among controls, 12.14 +/- 5.33 (P < 0.001). After adjusting for anxiety and depression scores, age and gender, native thiol remained lower and disulphide higher in the exposed group (P = 0.008 and P < 0.001). Conclusion: Dynamic thiol/disulphide homeostasis in workers exposed to anesthetic gases was found to be disturbed after adjusting for the possible contribution of anxiety. We infer that this is due to the oxidative effect of exposure to anesthetic gases.
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    Dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with urolithiasis
    (Korean Urological Assoc, 2019) Sonmez, Mehmet Giray; Kozanhan, Betul; Deniz, Cigdem Damla; Iyisoy, Mehmet Sinan; Kilinc, Muzaffer Tansel; Ecer, Gokhan; Ozturk, Ahmet
    Purpose: A dynamic thiol/disulfide balance is pivotal in organizing anti-oxidant defense, detoxification, apoptosis, and enzyme activities, as well as transcription and cellular signal-transfer mechanisms. The connection between urolithiasis and oxidant/antioxidant status, which can be assessed through thiol-disulfide homeostasis (TDH), has not yet been examined. In this study, we evaluated the effects of TDH on the formation, size, and location of stones by examining the associations between TDH parameters and urolithiasis. Materials and Methods: Patients with urolithiasis and healthy controls were recruited. The patients were divided into subgroups in terms of stone size (>15 mm or <= 15 mm) and stone location (nephrolithiasis or ureterolithiasis). TDH parameters were measured using a novel automatic and spectrophotometric method and compared statistically. Results: TDH parameters were different between the urolithiasis and control groups. TDH tended towards the disulfide side in the urolithiasis group. Stone size increased an average 0.14 mm with a 1 mu mol/L increase in disulfide level and decreased an average 0.058 mm with a 1 mu mol/L increase in native thiol level. Disulfide and native thiol levels were found to be different across patients with stone size >15 mm, <= 15 mm, and controls (p<0.001 and p<0.001, respectively). However, the nephrolithiasis and ureterolithiasis groups were similar in respect of TDH parameters. Conclusions: In this study, it was found that patients with urolithiasis displayed oxidative stress characterized by a TDH tendency towards the disulfide side, and an inadequate antioxidant response identified by a lower level of native thiol as compared with healthy controls.
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    Evaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation in rats
    (Oxford Univ Press, 2019) Deniz, Cigdem Damla; Aktan, Meryem; Erel, Ozcan; Gurbilek, Mehmet; Koc, Mehmet
    Ionizing radiation-induced free radicals cause functional and structural harmful effects. Thiol, an important antioxidant, plays a major role in the eradication of reactive oxygen molecules. Thiol/disulphide homeostasis is a marker of oxidative stress. The objective of this study was to assess the potential radioprotective effects of thymoquinone (TQ) on the dynamic thiol/disulphide homeostasis of rats receiving total-body irradiation (IR). Twenty-two rats were divided into three groups to test the radioprotective effectiveness of TQ. The sham control group did not receive TQ or IR. The IR group received only total-body IR. The TQ + IR group received IR plus TQ. Following IR, blood samples were taken. The thiol/disulphide homeostasis parameters were analysed by a newly established method. In the IR group, native thiol and the native thiol/total thiol ratio were significantly decreased (P = 0.003 and P = 0.003, respectively), whereas the disulphide/native thiol and disulphide/total thiol ratios were significantly increased when compared with those of the sham control group (P = 0.003 and P = 0.003, respectively). In the TQ + IR group, the mean disulphide, native thiol and total thiol levels and the disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were not found to be significantly different when compared with those of the sham control group (P > 0.05 for all). Thiol/disulphide homeostasis was found to be disturbed after IR exposure. The results showed that TQ had antioxidant effects and reduced the IR-induced oxidative stress, which was demonstrated through the dynamic thiol/disulphide homeostasis. Thus, the use of TQ before radiation treatment helped protect the rats from oxidant side effects.
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    THE USE OF ACUTE-PHASE PROTEINS APACHE II AND SOFA TO PREDICT THE MORTALITY OF COVID-19 PATIENTS
    (Nobel Ilac, 2023) Deniz, Cigdem Damla; Visneci, Emin Fatih; Eryilmaz, Mehmet Ali; Tutar, Mahmut Sami; Iyisoy, Mehmet Sinan; Ugur, Ayse Ruveyda; Koc, Mehmet
    Objective: Acute-phase proteins are a family of proteins synthesized by the liver. With this study, we aimed to investigate the effects of COVID-19 infection on acute phase reactants (AFR) and determine the usability of AFRs as prognostic factors in COVID-19 disease.Material and Method: Serum samples taken for routine analysis of the patients admitted to the Emergency Department and diagnosed with COVID-19, were used. AFR levels of 30 patients who resulted in mortality and 30 recovered patients were evaluated. C-reactive protein (CRP), ferritin (FER), ceruloplasmin (Cp), albumin (Alb), prealbumin (Prealb), transferrin (Trf), lactate, Acute Physiology and Chronic Health Evaluation (APACHE), and Sequential Organ Failure Assessment (SOFA) assessment was performed.Results: The hazard ratio and 95% confidence interval for FER, CRP, lactate, Alb, Cp, Prealb, Trf, Age, SOFA, and APACHE were 1.001 (1.000-1.001), 1.005 (1.001- 1.008), 1.141 (1.016-1.243), 1.016 (0.740-1.399), 1.016 (0.740-1.399), 1.056 (1.017-1.100), 0.978 (0.917-1.035), 1.000 (0.995-1.006), 1.032 (1.004- 1.064), 1.104 (0.971-1.247), and 1.012 (0.974-1.051), respectively, in univariable model. Only CRP, lactate, and FER found significant in multivariable model. In addition, patients in the nonsurvivors group had significantly higher FER, CRP, lactate, APACHE, age, and SOFA. Nonsurvivors also had lower Alb, Prealb, and serum Trf level compared to survivors.Conclusion: CRP, lactate, and FER, which we have shown to be significantly higher in severe COVID-19 patients, will be valuable parameters that will contribute to clinical improvement if they are used in the follow-up of patients due to their easy measurement and predictive values.