Dynamic thiol disulphide homeostasis in operating theater personnel exposed to anesthetic gases
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: The purpose of this study was to investigate the association between dynamic thiol/disulphide homeostasis and occupational exposure to volatile anesthetic gases in operating theater personnel. Decreased blood thiol levels and raised blood disulphide levels serve as biomarkers of oxidative stress. Methods: Weincluded 65 subjects occupationally exposed and 55 unexposed healthy medical professionals into the study. A novel method enabled separate measurements of components involved in dynamic thiol/disulphide homeostasis (native thiol, disulphide, and total thiol). To control for the potential confounding effect on oxidative stress of psychological symptoms potentially caused by occupational stress, we used scores obtained from four different anxiety and depression inventories. Results: Mean +/- standard deviation native thiol was found to be 433.35 +/- 30.68 in the exposed group, lower than among controls, 446.61 +/- 27.8 (P = 0.02). Disulphide in the exposed group was 15.78 +/- 5.12, higher than among controls, 12.14 +/- 5.33 (P < 0.001). After adjusting for anxiety and depression scores, age and gender, native thiol remained lower and disulphide higher in the exposed group (P = 0.008 and P < 0.001). Conclusion: Dynamic thiol/disulphide homeostasis in workers exposed to anesthetic gases was found to be disturbed after adjusting for the possible contribution of anxiety. We infer that this is due to the oxidative effect of exposure to anesthetic gases.
Açıklama
Anahtar Kelimeler
Anesthetic Gases, Anxiety, Occupational Exposure, Oxidative Stress, Thiol/Disulphide Homeostasis
Kaynak
American Journal Of Industrial Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
60
Sayı
11
