Dynamic thiol disulphide homeostasis in operating theater personnel exposed to anesthetic gases

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dc.contributor.authorKozanhan, Betul
dc.contributor.authorInanli, Ikbal
dc.contributor.authorDeniz, Cigdem Damla
dc.contributor.authorIyisoy, Mehmet Sinan
dc.contributor.authorNeselioglu, Salim
dc.contributor.authorSahin, Osman
dc.contributor.authorAkin, Fatma
dc.date.accessioned2024-02-22T20:49:59Z
dc.date.available2024-02-22T20:49:59Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: The purpose of this study was to investigate the association between dynamic thiol/disulphide homeostasis and occupational exposure to volatile anesthetic gases in operating theater personnel. Decreased blood thiol levels and raised blood disulphide levels serve as biomarkers of oxidative stress. Methods: Weincluded 65 subjects occupationally exposed and 55 unexposed healthy medical professionals into the study. A novel method enabled separate measurements of components involved in dynamic thiol/disulphide homeostasis (native thiol, disulphide, and total thiol). To control for the potential confounding effect on oxidative stress of psychological symptoms potentially caused by occupational stress, we used scores obtained from four different anxiety and depression inventories. Results: Mean +/- standard deviation native thiol was found to be 433.35 +/- 30.68 in the exposed group, lower than among controls, 446.61 +/- 27.8 (P = 0.02). Disulphide in the exposed group was 15.78 +/- 5.12, higher than among controls, 12.14 +/- 5.33 (P < 0.001). After adjusting for anxiety and depression scores, age and gender, native thiol remained lower and disulphide higher in the exposed group (P = 0.008 and P < 0.001). Conclusion: Dynamic thiol/disulphide homeostasis in workers exposed to anesthetic gases was found to be disturbed after adjusting for the possible contribution of anxiety. We infer that this is due to the oxidative effect of exposure to anesthetic gases.en_US
dc.identifier.doi10.1002/ajim.22764
dc.identifier.endpage1009en_US
dc.identifier.issn0271-3586
dc.identifier.issn1097-0274
dc.identifier.issue11en_US
dc.identifier.pmid28857280en_US
dc.identifier.scopus2-s2.0-85028534253en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1003en_US
dc.identifier.urihttps://doi.org/10.1002/ajim.22764
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10514
dc.identifier.volume60en_US
dc.identifier.wosWOS:000416694900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAmerican Journal Of Industrial Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthetic Gasesen_US
dc.subjectAnxietyen_US
dc.subjectOccupational Exposureen_US
dc.subjectOxidative Stressen_US
dc.subjectThiol/Disulphide Homeostasisen_US
dc.titleDynamic thiol disulphide homeostasis in operating theater personnel exposed to anesthetic gasesen_US
dc.typeArticleen_US

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