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    Acute Deep Venous Thrombosis Associated with Acute Brucellosis: A Case Report
    (Aves, 2012) Kocak, Sedat; Dikmetas, Cesarettin; Dundar, Zerrin D.; Erdemir, Esma; Kesli, Recep
    Brucellosis continues to be one of the most widespread zoonoses worldwide. Human brucellosis is a multisystem disease that may present with a broad spectrum of clinical manifestations, but it may also be asymptomatic with only serological evidence of infection. In this paper, a case report is presented of deep venous thrombosis (DVT) developing after a diagnosis of acute brucellosis in a young slaughterhouse worker. A 26-year-old man was diagnosed with DVT which had presented with the complaints of weakness and fever and a one-week history of pain and swelling in the right leg. Ultrasound revealed that the right femoral and popliteal veins were occluded with thrombi. Brucella was diagnosed using Rose-Bengal, tube agglutination, the Brucellacapt test and an enzyme-linked immunoassay using anti-Brucella abortus IgM/G antibody detection at another institution. Although rare, some infectious agents may cause vascular pathologies. These conditions may be life-threatening. Thus, it should be kept in mind that vascular complications may occur during infectious disease and patients should be monitored. Additionally, patients presenting with symptoms of DVT or similar vascular pathologies should be assessed for infectious agents, particularly Brucella and Salmonella, as well as other risk factors.
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    Prognostic Value of Immunosuppressive Acidic Protein (IAP) and Oxidative Stress Status in Critically Ill Patients
    (Jaypee Brothers Medical Publishers Pvt Ltd, 2021) Tutuncu, Elif O.; Dundar, Zerrin D.; Kilinc, Ibrahim; Tutuncu, Aziz; Kocak, Sedat; Girisgin, Abdullah S.
    Introduction:The aim of this study was to determine the prognostic value of admission immunosuppressive acidic protein (IAP), interleukin-6 (IL-6), total oxidant status (TOS), and total antioxidant status (TAS) in 161 critically ill patients. Materials and methods: This prospective observational study was carried out in the Emergency Department ICU for 6 months.Critically ill patients were included in the study consecutively. The main outcomes were the need for early mechanical ventilation (MV) and in-hospital mortality. Results:The mean age of 161 patients was 66.5 +/- 17.1 years.The median IL-6 levels of patients who required early MV were significantly higher than ofthe patients who required no MV (p <0.001), and the median IL-6 levels in the non-survivors were significantly higher than in the survivors (p < 0.001). The median IAP levels were not significantly different between the groups (p = 0.464 for early MV and p = 0.340 for the in-hospital mortality group). The AUCs of IL-6 and TOS for predicting in-hospital mortality were 0.819 and 0.608, respectively. Conclusion: The IAP level on admission to ICU is ineffective in predicting the need for early MV and in-hospital mortality; however, iL-6 level on admission is a strong prognostic predictor in critically ill patients. Our findings showed that the burden of oxidative stress was high in general ICU patients. Clinical significance: Our study showed that increased oxidative stress is an important problem in critically ill patients. If measures are taken to reduce oxidative stress by physicians, the prognosis of critically ill patients will be better.