Prognostic Value of Immunosuppressive Acidic Protein (IAP) and Oxidative Stress Status in Critically Ill Patients
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Jaypee Brothers Medical Publishers Pvt Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction:The aim of this study was to determine the prognostic value of admission immunosuppressive acidic protein (IAP), interleukin-6 (IL-6), total oxidant status (TOS), and total antioxidant status (TAS) in 161 critically ill patients. Materials and methods: This prospective observational study was carried out in the Emergency Department ICU for 6 months.Critically ill patients were included in the study consecutively. The main outcomes were the need for early mechanical ventilation (MV) and in-hospital mortality. Results:The mean age of 161 patients was 66.5 +/- 17.1 years.The median IL-6 levels of patients who required early MV were significantly higher than ofthe patients who required no MV (p <0.001), and the median IL-6 levels in the non-survivors were significantly higher than in the survivors (p < 0.001). The median IAP levels were not significantly different between the groups (p = 0.464 for early MV and p = 0.340 for the in-hospital mortality group). The AUCs of IL-6 and TOS for predicting in-hospital mortality were 0.819 and 0.608, respectively. Conclusion: The IAP level on admission to ICU is ineffective in predicting the need for early MV and in-hospital mortality; however, iL-6 level on admission is a strong prognostic predictor in critically ill patients. Our findings showed that the burden of oxidative stress was high in general ICU patients. Clinical significance: Our study showed that increased oxidative stress is an important problem in critically ill patients. If measures are taken to reduce oxidative stress by physicians, the prognosis of critically ill patients will be better.
Açıklama
Anahtar Kelimeler
Immunosuppressive Acidic Protein, In-Hospital Mortality, Interleukins, Oxidative Stress
Kaynak
Indian Journal Of Critical Care Medicine
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
25
Sayı
4
