Prognostic Value of Immunosuppressive Acidic Protein (IAP) and Oxidative Stress Status in Critically Ill Patients

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dc.contributor.authorTutuncu, Elif O.
dc.contributor.authorDundar, Zerrin D.
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorTutuncu, Aziz
dc.contributor.authorKocak, Sedat
dc.contributor.authorGirisgin, Abdullah S.
dc.date.accessioned2024-02-23T14:40:53Z
dc.date.available2024-02-23T14:40:53Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIntroduction:The aim of this study was to determine the prognostic value of admission immunosuppressive acidic protein (IAP), interleukin-6 (IL-6), total oxidant status (TOS), and total antioxidant status (TAS) in 161 critically ill patients. Materials and methods: This prospective observational study was carried out in the Emergency Department ICU for 6 months.Critically ill patients were included in the study consecutively. The main outcomes were the need for early mechanical ventilation (MV) and in-hospital mortality. Results:The mean age of 161 patients was 66.5 +/- 17.1 years.The median IL-6 levels of patients who required early MV were significantly higher than ofthe patients who required no MV (p <0.001), and the median IL-6 levels in the non-survivors were significantly higher than in the survivors (p < 0.001). The median IAP levels were not significantly different between the groups (p = 0.464 for early MV and p = 0.340 for the in-hospital mortality group). The AUCs of IL-6 and TOS for predicting in-hospital mortality were 0.819 and 0.608, respectively. Conclusion: The IAP level on admission to ICU is ineffective in predicting the need for early MV and in-hospital mortality; however, iL-6 level on admission is a strong prognostic predictor in critically ill patients. Our findings showed that the burden of oxidative stress was high in general ICU patients. Clinical significance: Our study showed that increased oxidative stress is an important problem in critically ill patients. If measures are taken to reduce oxidative stress by physicians, the prognosis of critically ill patients will be better.en_US
dc.description.sponsorshipResearch Fund of Necmettin Erbakan University [151518006]en_US
dc.description.sponsorshipThe study was supported by the Research Fund of Necmettin Erbakan University (Project no. 151518006).en_US
dc.identifier.doi10.5005/jp-journals-10071-23788
dc.identifier.endpage410en_US
dc.identifier.issn0972-5229
dc.identifier.issn1998-359X
dc.identifier.issue4en_US
dc.identifier.pmid34045807en_US
dc.identifier.scopus2-s2.0-85111785459en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.5005/jp-journals-10071-23788
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16628
dc.identifier.volume25en_US
dc.identifier.wosWOS:000635122500014en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJaypee Brothers Medical Publishers Pvt Ltden_US
dc.relation.ispartofIndian Journal Of Critical Care Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectImmunosuppressive Acidic Proteinen_US
dc.subjectIn-Hospital Mortalityen_US
dc.subjectInterleukinsen_US
dc.subjectOxidative Stressen_US
dc.titlePrognostic Value of Immunosuppressive Acidic Protein (IAP) and Oxidative Stress Status in Critically Ill Patientsen_US
dc.typeArticleen_US

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