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    Dynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver disease
    (Walter De Gruyter Gmbh, 2018) Asil, Mehmet; Dertli, Ramazan; Biyik, Murat; Yolacan, Ramazan; Erel, Ozcan; Neselioglu, Salim; Ataseven, Huseyin
    Background: Oxidative stress has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Plasma thiols are major defense mechanisms against oxidative stress and undergo oxidation to form disulfides under oxidative conditions. This study was conducted to investigate thiol-disulfide homeostasis in NAFLD patients. Methods: Thirty patients with biopsy proven non-alcoholic steatohepatitis (NASH), 40 patients with simple steatosis and 50 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the Erel and Neselioglu's method. Results: The mean serum total thiol concentrations in the NASH, simple steatosis and control groups were 415 +/- 64 mu mol/L, 447 +/- 38 mu mol/L and 480 +/- 37 mu mol/L, respectively (p < 0.001). The mean serum native thiol concentrations in the NASH, simple steatosis and control groups were 378 +/- 62 mu mol/L, 416 +/- 41 mu mol/L and 451 +/- 36 mu mol/L, respectively (p < 0.001). The mean serum disulfide concentrations in the NASH, simple steatosis and control groups were 18.5 +/- 6.3 mu mol/L, 15.5 +/- 4.8 mu mol/L and 14.9 +/- 3.6 mu mol/L, respectively (p = 0.005). The native thiol/total thiol ratio was significantly lower and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the NASH group than in the simple steatosis and control groups. Conclusions: Thiol-disulfide homeostasis is disturbed and shifted toward disulfide side in NAFLD and NASH patients.
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    Dynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver disease
    (Walter De Gruyter Gmbh, 2018) Asil, Mehmet; Dertli, Ramazan; Biyik, Murat; Yolacan, Ramazan; Erel, Ozcan; Neselioglu, Salim; Ataseven, Huseyin
    Background: Oxidative stress has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Plasma thiols are major defense mechanisms against oxidative stress and undergo oxidation to form disulfides under oxidative conditions. This study was conducted to investigate thiol-disulfide homeostasis in NAFLD patients. Methods: Thirty patients with biopsy proven non-alcoholic steatohepatitis (NASH), 40 patients with simple steatosis and 50 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the Erel and Neselioglu's method. Results: The mean serum total thiol concentrations in the NASH, simple steatosis and control groups were 415 +/- 64 mu mol/L, 447 +/- 38 mu mol/L and 480 +/- 37 mu mol/L, respectively (p < 0.001). The mean serum native thiol concentrations in the NASH, simple steatosis and control groups were 378 +/- 62 mu mol/L, 416 +/- 41 mu mol/L and 451 +/- 36 mu mol/L, respectively (p < 0.001). The mean serum disulfide concentrations in the NASH, simple steatosis and control groups were 18.5 +/- 6.3 mu mol/L, 15.5 +/- 4.8 mu mol/L and 14.9 +/- 3.6 mu mol/L, respectively (p = 0.005). The native thiol/total thiol ratio was significantly lower and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the NASH group than in the simple steatosis and control groups. Conclusions: Thiol-disulfide homeostasis is disturbed and shifted toward disulfide side in NAFLD and NASH patients.
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    Evaluation of the radioprotective effects of thymoquinone on dynamic thiol-disulphide homeostasis during total-body irradiation in rats
    (Oxford Univ Press, 2019) Deniz, Cigdem Damla; Aktan, Meryem; Erel, Ozcan; Gurbilek, Mehmet; Koc, Mehmet
    Ionizing radiation-induced free radicals cause functional and structural harmful effects. Thiol, an important antioxidant, plays a major role in the eradication of reactive oxygen molecules. Thiol/disulphide homeostasis is a marker of oxidative stress. The objective of this study was to assess the potential radioprotective effects of thymoquinone (TQ) on the dynamic thiol/disulphide homeostasis of rats receiving total-body irradiation (IR). Twenty-two rats were divided into three groups to test the radioprotective effectiveness of TQ. The sham control group did not receive TQ or IR. The IR group received only total-body IR. The TQ + IR group received IR plus TQ. Following IR, blood samples were taken. The thiol/disulphide homeostasis parameters were analysed by a newly established method. In the IR group, native thiol and the native thiol/total thiol ratio were significantly decreased (P = 0.003 and P = 0.003, respectively), whereas the disulphide/native thiol and disulphide/total thiol ratios were significantly increased when compared with those of the sham control group (P = 0.003 and P = 0.003, respectively). In the TQ + IR group, the mean disulphide, native thiol and total thiol levels and the disulphide/native thiol, disulphide/total thiol and native thiol/total thiol ratios were not found to be significantly different when compared with those of the sham control group (P > 0.05 for all). Thiol/disulphide homeostasis was found to be disturbed after IR exposure. The results showed that TQ had antioxidant effects and reduced the IR-induced oxidative stress, which was demonstrated through the dynamic thiol/disulphide homeostasis. Thus, the use of TQ before radiation treatment helped protect the rats from oxidant side effects.
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    Impaired Thiol-Disulfide Balance in Acute Brucellosis
    (Natl Inst Infectious Diseases, 2017) Kolgelier, Servet; Ergin, Merve; Demir, Lutfi Saltuk; Inkaya, Ahmet Cagkan; Demir, Nazlim Aktug; Alisik, Murat; Erel, Ozcan
    The objective of this study was to examine a novel profile: thiol-disulfide homeostasis in acute brucellosis. The study included 90 patients with acute brucellosis, and 27 healthy controls. Thiol-disulfide profile tests were analyzed by a recently developed method, and ceruloplasmin levels were determined. Native thiol levels were 256.72 +/- 48.20 mu mol/L in the acute brucellosis group and 461.13 +/- 45.37 mu mol/L in the healthy group, and total thiol levels were 298.58 +/- 51.78 mu mol/L in the acute brucellosis group and 504.83 +/- 51.05 mu mol/L in the healthy group (p < 0.001, for both). The disulfide/native thiol ratios and disulfide/total thiol ratios were significantly higher, and native thiol/total thiol ratios were significantly lower in patients with acute brucellosis than in the healthy controls (p < 0.001, for all ratios). There were either positive or negative relationships between ceruloplasmin levels and thiol-disulfide parameters. The thiol-disulfide homeostasis was impaired in acute brucellosis. The strong associations between thiol-disulfide parameters and a positive acute-phase reactant reflected the disruption of the balance between the antioxidant and oxidant systems. Since thiol groups act as anti-inflammatory mediators, the alteration in the thiol-disulfide homeostasis may be involved in brucellosis.
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    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.
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    Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia
    (Walter De Gruyter Gmbh, 2019) Arican, Sule; Hacibeyoglu, Gulcin; Ulukaya, Sinan Oguzhan; Avcioglu, Gamze; Reisli, Ruhiye; Uzun, Sema Tuncer; Erel, Ozcan
    Background: Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods: A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to measure serum IMA levels. Results: Serum IMA levels were 1.21 +/- 0.58 AU and 0.75 +/- 0.09 AU in the PHN and control groups, respectively (p <0.001). Serum total thiol concentrations were found to be 421.62 +/- 90.28 mu mol/L and 598.36 +/- 73.63 mu mol/L in the PHN and control groups, respectively (p <0.001). Serum native thiol concentrations were found to be 365.75 +/- 92.07 mu mol/L and 531.90 +/- 72.9 mu mol/L in the PHN and control groups, respectively (p < 0.001). Serum disulfide concentrations were found to be 33.23 +/- 5.33 mu mol/L and 27.93 +/- 7.81 mu mol/L in the PHN and control groups, respectively (p= 0.003). The native thiol/total thiol ratio was significantly lower, and the disulfide/total thiol and disulfide/native thiol ratios were significantly higher in the PHN group compared to the controls. Conclusions: IMA levels are high and dynamic thiol/disulfide homeostasis is disrupted in PHN patients.