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Öğe The effect of Halofuginone in the amelioration of radiation induced-lung fibrosis(Churchill Livingstone, 2013) Yavas, Guler; Calik, Mustafa; Calik, Goknil; Yavas, Cagdas; Ata, Ozlem; Esme, HidirThe lung is one of the most sensitive organs to ionizing radiation, and damage to normal lung tissue remains a major dose limiting factor for patients receiving radiation to the thorax. Radiation induced lung injury (RILI) which is also named as radiation pneumonpathy is a continuous process and regarded as the result of an abnormal healing response. It has been shown that transforming growth factor beta-1 (TGF-beta 1) plays an integral role in the radiation induced lung fibrosis formation by promoting the chemoattraction of fibroblasts and their conversion to myofibroblasts. Halofuginone is a, low molecular weight plant derived alkaloid, isolated from the Dichroa febnfuga plant that exhibits antifibrotic activity and inhibition of type I collagen synthesis. Halofuginone has been shown to protect against radiation induced soft tissue fibrosis by virtue of inhibiting various members of TFG-beta signaling pathway. By the light of these findings, we hypothesize that Halofuginone may be able to ameliorate the radiation induced lung fibrosis. (C) 2013 Elsevier Ltd. All rights reserved.Öğe Effect of morphine sulphate on histopathologic changes in lung tissue after ischemia reperfusion injury(European Respiratory Soc Journals Ltd, 2018) Duzgun, Nuri; Esme, Hidir; Karabagli, Pinar; Iyisoy, Mehmet Sinan; Duran, Melike[Abstract Not Availabe]Öğe Effects of topical mitomycin-C on the tracheal epithelia of rabbits following tracheostomy(Tubitak Scientific & Technological Research Council Turkey, 2021) Calik, Saniye Goknil; Calik, Mustafa; Kasdogan, Zumrut Ela Arslan; Avunduk, Mustafa Cihat; Aribas, Olgun Kadir; Esme, HidirBackground/aim: We aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model. Materials and methods: Twenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Tracheostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC). Results: There was a statistically significant difference between the two tracheostomy groups themselves and the control group for LD (p = 0.035), CV (p = 0.006), SETT, fibroblasts, and IC (p < 0.001). Histopathological analysis showed the decreased LD, CV, SETT, IC, and fibroblasts compared to MMC with tracheostomy groups. MMC was more effective than saline for LD, CV, SETT, IC, and fibroblasts. Conclusion: Wound healing modulation may prevent scar formation. Fibrosis decreased following tracheostomy in the group treated with MMC. Fibroblasts appear to be key cells mediating these effects.Öğe Evaluation of rhomboid intercostal and subserratus plane block under direct vision for postoperative analgesia in thoracic surgeries: a prospective, randomized controlled trial(Oxford Univ Press Inc, 2022) Kozanhan, Betul; Semerkant, Tolga; Esme, Hidir; Canitez, Ahmet; Iyisoy, Mehmet SinanOBJECTIVES: This study is designed to evaluate the efficacy of rhomboid intercostal and subserratus plane (RISS) block under the surgeon's direct vision for providing postoperative pain relief after thoracic surgeries. METHODS: Forty patients who underwent thoracotomy were prospectively recruited and randomly assigned to group R (intravenous patient-controlled analgesia + continued RISS block; n = 20) and group C (intravenous patient-controlled analgesia; n = 20). Numeric rating scale at rest and cough, at post-anaesthetic care unit, 1, 2, 6, 9, 12, 24 and 48 h, was used as the primary outcome measure. Secondary outcome measures were the amount of tramadol consumption, the number of patients required rescue analgesia, the occurrence of postoperative adverse effects, pulmonary functions and the overall satisfaction with pain management. RESULTS: Numeric rating scale scores both at rest and during coughing were significantly lower in group R than in group C at all time intervals (P < 0.001 in each). Tramadol consumption at 24 and 48 h was significantly lower in the group R block than in group C (P < 0.001 for each). None of the patients in group R requires rescue analgesia. The incidence of nausea and vomiting was similar among the groups. Compared with group C, change in lung function from baseline levels was significantly less in group R (P = 0.047 and P = 0.04 for FEV1 and FVC, respectively). The satisfaction scores in group R were significantly higher than that in group C (P < 0.001). CONCLUSIONS: Continuous RISS block improved postoperative outcomes of thoracic surgery in terms of reduced postoperative pain scores, sparing opioid consumption, pulmonary function and patient satisfaction.Öğe Headscarf Pin Localized in the Right Main Bronchus and Two Pins in the Abdomen(Modestum Ltd, 2015) Apilliogullari, Burhan; Duzgun, Nuri; Esme, Hidir; Yavsan, MehmetTracheobronchial foreign body aspiration is a serious condition that might result in mortality and it necessitates emergency intervention. Studies in literature report cases of pin aspiration related to headscarf use in Muslim countries. The most frequent symptom in foreign body aspirations is coughing. Radio-opaque foreign bodies can be detected through lung radiology. Following diagnosis, the foreign body needs to be removed as soon as possible. The removal procedure is carried out by flexible fiberoptic bronchoscopy or rigid bronchoscope. We hereby present the case of a patient who presented to the emergency department with headscarf pin aspiration and whose radiography results revealed 2 pins in the abdomen and one pin in the right main bronchus.Öğe Headscarf Pin Localized in the Right Main Bronchus and Two Pins in the Abdomen(Modestum Ltd, 2015) Apilliogullari, Burhan; Duzgun, Nuri; Esme, Hidir; Yavsan, MehmetTracheobronchial foreign body aspiration is a serious condition that might result in mortality and it necessitates emergency intervention. Studies in literature report cases of pin aspiration related to headscarf use in Muslim countries. The most frequent symptom in foreign body aspirations is coughing. Radio-opaque foreign bodies can be detected through lung radiology. Following diagnosis, the foreign body needs to be removed as soon as possible. The removal procedure is carried out by flexible fiberoptic bronchoscopy or rigid bronchoscope. We hereby present the case of a patient who presented to the emergency department with headscarf pin aspiration and whose radiography results revealed 2 pins in the abdomen and one pin in the right main bronchus.Öğe Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury(Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2014) Apiliogullari, Burhan; Kesli, Recep; Esme, Hidir; Yuceaktas, Ali; Yoldas, BanuBackground: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R). Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated. Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S. Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury.
