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    Analysis of navicular drop test values of patients with plantar fasciitis
    (Bayrakol Medical Publisher, 2022) Dikici, Rumeysa; Uysal, Ismihan Ilknur; Karahan, Ali Yavuz; Fazliogullari, Zeliha
    Aim: The aim of this study is to investigate the usability of navicular drop test (NDT) in the diagnosis of plantar fasciitis (PFs). Material and Methods: Fifty patients aged 35-60 years who were diagnosed with PF in the physical therapy clinic and 50 healthy participants in the same age range were included in this study. Age, height, weight, dominant lower extremity of all participants were determined and body mass index was calculated. The navicular drop test measurements of all participants were performed. Data were compared between the two groups. Results: The body mass index (BMI) in the PFs group was statistically significantly higher than in the control group (p<0.05). The right foot was dominant (93%) in both groups and PFs was more common on the right side in the patient group (p<0,05). The NDT data were statistically significantly higher in the PFs group on the right and left sides. Discussion: Besides the fact that BMI is an important risk factor for the formation of PF, an increase in the amount of displacement in the navicular tubercle due to overloading of the extremity may further increase this risk. We believe that the diagnosis of PFs can be supported by NDT in physical examination.
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    Classification and volumetric study of the sphenoid sinus on MDCT images
    (Springer, 2019) Pirinc, Busra; Fazliogullari, Zeliha; Guler, Ibrahim; Unver Dogan, Nadire; Uysal, Ismihan Ilknur; Karabulut, Ahmet Kagan
    Purpose We aimed to determine the position and size of the sphenoid sinus (SS) in our study and compare the results of the measurements relative to age, gender, and the presence of pituitary adenoma using multidetector computerized tomography (MDCT). Methods We retrospectively evaluated the paranasal sinus computerized tomography (CT) images of 200 individuals (age range of all the individuals 4-84 years; 101 females, 99 males; age range of individuals with pituitary adenoma 15-63 years; 15 females, 9 males) with 24 pituitary adenomas. The shape of SS were identified and classified, volume were measured by MDCT also for individuals with pituitary adenoma. Results It was determined that the volume averages were significantly affected by the type of SS. Among all the individuals studied, the sellar type of SS was most frequently observed (41.5%), followed by the postsellar type (38.5%), and the least observed was the presellar type (9%). The volume of the SS is bigger in males than females although the volume is not affected by the presence of pituitary adenomas. The development of the SS continues until the age of nine. Conclusion The morphology and morphometry of the SS show individual differences. These anatomic variations are important for decision making and application for surgical interventions (especially transsphenoidal surgery).
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    Clinical evaluation of cerebral MRI findings in children with cerebral palsy
    (Bayrakol Medical Publisher, 2022) Durmaz, Sevda Canbay; Karabulut, Ahmet Kagan; Gungor, Serdal; Fazliogullari, Zeliha; Uysal, Ismihan Ilknur; Unver Dogan, Nadire
    Aim: In this study, we aimed to investigate the frequency of lesions, which show the hypoxic-ischemic brain damage, their anatomical localization, the timing of the occurrence of the lesions and the causes using the magnetic resonance imaging (MRI) method.Material and Methods: MRI findings of 150 patient with cerebral palsy (CP) were analyzed. MRI findings, patients' ages, gender, type of birth, birth ages, relationship of parents, additional diseases to CP and clinical type of CP were evaluated. As a control group, 100 healthy children with normal MRI findings of the same age, their gender, types of birth, birth ages, parents relationship and data were compared with the data of children with CPResults: When etiological factors of CP and the control group were compared, male children were found to be more affected than female. In the age groups, children aged 1-5 were determined to have cerebral palsy more than in the other groups. Related with CP ethiogenesis, prematurity and low birth weight play important roles. On the other hand, negative hospital conditions during and after the birth as well as the curative effect of rapidly developing medical technologies on the babies with high mortality, also have important effects on CP ethiogenesis.Discussion: Our results show that there are some similarities and differences between the cerebral palsy group and the controls. It was also determined that the MRI method is important in CP diagnosis. Anatomical localisations of the lesions in the brain support the relevant clinical symptoms and thus play an important role in the differential diagnosis.
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    In vitro study of the toxic and teratogenic effects of prednisolone, azathioprine and mycophenolate mofetile on embryological development of rats
    (Taylor & Francis Ltd, 2022) Fazliogullari, Zeliha; Karabulut, Ahmet Kagan; Unver Dogan, Nadire; Uysal, Ismihan Ilknur; Acar, Hasan
    This study aimed to evaluate the effects of the glucocorticoid prednisolone, the mycophenolic acid prodrug, azathioprine, and the fungi fermentation end product, mycophenolate mofetile on the embryological development of rats. Nine day-old rat embryos were cultured in rat serum containing prednisolone at varying concentrations (5-30 mu g/ml) for 48 h. The test groups were cultured separately in rat serum containing 0.3-10 mu g/ml azathioprine and 1-10 mu g/ml mycophenolate mofetile. Embryonic development parameter effects of both drugs in combination with prednisolone (20 mu g/ml) were studied using morphological methods, with special attention given to the incidence of malformations. The genotoxic effects of agents evaluated with the TUNEL test revealed that prednisolone is not a cause of developmental toxicity. The maximum safe dose of prednisolone that could be used in combination with other immunosuppressive agents was determined to be 20 mu g/ml. Azathioprine was found to be toxic and teratogenic for the rat embryos beginning at a dose of 1 mu g/ml. Dose-dependent toxic and teratogenic effects of mycophenolate mofetile were detected at doses lower than normal clinical ones.
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    Mental foramen and lingual vascular canals of mandible on MDCT images: anatomical study and review of the literature
    (Springer, 2018) Direk, Filiz; Uysal, Ismihan Ilknur; Kivrak, Ali Sami; Fazliogullari, Zeliha; Unver Dogan, Nadire; Karabulut, Ahmet Kagan
    The mental foramen and lingual vascular canals are related to vessels and nerves in the mandibular body. The aim of the present study was to determine the number and location of these structures and to make measurements of them. The archived Multidetector Computed Tomography images of 100 adult (15- to 70-year-old) patients were evaluated retrospectively. The diameters of the mental foramens and their distances from the front, back, upper and lower reference points were measured. The distribution of mental foramens with respect to the teeth was also researched. The presence of lingual vascular canals, and the number of median and lateral canals was determined, and the length of the median lingual vascular canals measured. All measurement parameters were analyzed by gender, side and age group. Eleven patients demonstrated a total of 15 accessory mental foramen. Median lingual vascular canals were observed in 100% of cases, with lateral lingual vascular canals determined in 32%. Significant differences were observed in the results of different gender groups (P < 0.05); in contrast, no significant difference was observed related with age or side. Accessory mental foramen was determined mostly in males, and unilaterally on the right side; also, the distances of mental foramen, except the distance from the back border of the mandible (P < 0.05), were found to be higher, bilaterally, in males. Variation of mental foramen, as well as the presence, position and size of lingual vascular canals can be clearly investigated by multidetector computed tomography. A preoperative knowledge of the positions of neurovascular and bone structures is very important for preventing complications that may occur during or after operations.
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    Reevaluation of Mandibular Morphometry According to Age, Gender, and Side
    (Lippincott Williams & Wilkins, 2018) Direk, Filiz; Uysal, Ismihan Ilknur; Kivrak, Ali Sami; Unver Dogan, Nadire; Fazliogullari, Zeliha; Karabulut, Ahmet Kagan
    Aim: This study aims to reevaluation the linear and angular measurements of mandibles with multidetector computed tomography (MDCT) that is a new method and used frequently in recent years. Materials and Methods: The archived MDCT images of 100 adult patients (age range, 15-74 years) without mandibular operation and trauma history were evaluated retrospectively. Mandibular ramus heights, maximal mandibular length, mandibular symphysis height, mandibular angles, and mandibular foramen distance measurements were performed on MDCT images. All measurement parameters were analyzed by gender, age groups, and sides. Results: Mandibular linear length measurements were higher in males than in females (P<0.05). Only mandibular symphysis height was statistically significantly different in age groups (P<0.05). The Angle 1 (gonial angle) was found to be significantly higher in females (P<0.05). The Angle 3 (right condyle-gnathion-left condyle angle) was observed to be significantly higher in the 60+ age group (P<0.05). The 3 of the mandibular foramen measurements (distance from the front edge, distance to gonion, and height of lingula) were found to be higher in males than in females (P<0.05). There were no significant differences according to age groups in these measurements. The lengths of the mandibular canals were higher in males (44.72mm) than in females (41.68mm). There was no statistically significant difference was found between gender, age groups, and sides of mandibular canal length. Conclusion: The MDCT was found to be a reliable method for the detection of mandibular morphometry when compared with the results of other radiographic images studies.