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Öğe Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood(Korean Coll Neuropsychopharmacology, 2019) Sonmez, Erdem Onder; Uguz, Faruk; Sahingoz, Mine; Sonmez, Gulsum; Kaya, Nazmiye; Camkurt, Mehmet Akif; Gokmen, ZeynelObjective: We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. Methods: A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. Results: The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn't find any correlation between the umbilical cord blood BDNF levels and BDI scores. Conclusion: The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.Öğe The haemodynamic effects of umbilical cord milking in term infants: a randomised controlled trial(Wolters Kluwer Medknow Publications, 2023) Tekin, Mehmet; Gokdemir, Mahmut; Toprak, Erzat; Silahli, Musa; Energin, Hasan; Gokmen, ZeynelIntroduction: Umbilical cord milking (UCM) is a method that allows for postnatal placental transfusion. The benefits of UCM have been demonstrated in some studies, but knowledge about its haemodynamic effects in term infants is limited. The aim of this study was to evaluate the haemodynamic effects of UCM in term infants. Methods: In this prospective, randomised controlled study, 149 healthy term infants with a birth week of >= 37 weeks were randomly assigned to either the UCM or immediate cord clamping (ICC) group. Blinded echocardiographic evaluations were performed in all the neonates in the first 2-6 h. Results: Superior vena cava (SVC) flow measurements were higher in the UCM group compared to the ICC group (132.47 +/- 37.0 vs. 126.62 +/- 34.3 mL/kg/min), but this difference was not statistically significant. Left atrial diameter (12.23 +/- 1.99 vs. 11.43 +/- 1.78 mm) and left atrium-to-aorta diastolic diameter ratio (1.62 +/- 0.24 vs. 1.51 +/- 0.22) were significantly higher in the UCM group. There were no significant differences in other echocardiographic parameters between the two groups. Conclusion: We found no significant difference in the SVC flow measurements in term infants who underwent UCM versus those who underwent ICC. This lack of significant difference in SVC flow may be explained by the mature cerebral autoregulation mechanism in term neonates.Öğe Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels(Pergamon-Elsevier Science Ltd, 2013) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, GulsumObjectives: The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD. Methods: Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery. Results: Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels. Conclusions: The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. (C) 2013 Elsevier Inc. All rights reserved.Öğe Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: A comparative study on cord blood tumor necrosis factor-alpha levels(W B Saunders Co-Elsevier Inc, 2014) Uguz, Faruk; Sonmez, Erdem Onder; Sahingoz, Mine; Gokmen, Zeynel; Basaran, Mustafa; Gezginc, Kazim; Sonmez, GulsumObjective: The relationship between maternal psychiatric disorders and fetal neurodevelopment is unclear. Obsessive-compulsive disorder (OCD) is relatively frequent during pregnancy. The study aimed to investigate whether maternal OCD during pregnancy affects fetal circulating tumor necrosis factor-alpha (TNF-alpha) levels, an important pro-inflammatory cytokine, by comparing cord blood TNF-alpha levels in newborn infants of women with and without OCD. Methods: The study sample included 7 women with OCD and 30 healthy women. OCD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of TNF-alpha level was obtained from the umbilical cord during delivery. Results: Cord blood TNF-alpha levels in newborn infants exposed to maternal OCD were significantly higher compared to non-exposed infants. Maternal anxiety symptom level was found to positively correlate with cord blood TNF-alpha levels in newborn infants of women with OCD. Conclusion: The study results imply that maternal OCD during pregnancy may lead to neuroinflammation in the developing fetal brain through higher levels of circulating TNF-alpha. (C) 2014 Elsevier Inc. All rights reserved.
