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Öğe Do We Need to Replace GH to Correct Anemia in Hypopituitarism?(Endocrine Soc, 2014) Kulaksizoglu, Mustafa; Ipekci, Suleyman Hilmi; Gonulalan, Gulsum; Ozturk, Mine; Kaya, Ahmet; Gonen, Mustafa Sait; Cakir, Mehtap[Abstract Not Availabe]Öğe The Effect of Hypothyroidism on Color Contrast Sensitivity: A Prospective Study(Karger, 2015) Cakir, Mehtap; Ozturk, Banu Turgut; Turan, Elif; Gonulalan, Gulsum; Polat, Ilker; Gunduz, KemalBackground: Thyroid hormone has been shown to control retinal cone opsin expression, the protein of color vision, in adult rodents. Objectives: The aim of this study was to evaluate the effect of hypothyroidism on color contrast sensitivity in adult overt hypothyroid patients. Methods: Thirtyeight overt hypothyroid (31 females, 7 males) subjects and 20 euthyroid (16 females, 4 males) controls were studied prospectively. Color vision examination was performed by Chromatest, a software program analyzing the tritan (blueyellow) color contrast threshold (tritan CCT) and protan (redgreen) color contrast threshold (protan CCT). Color contrast sensitivity analyses of hypothyroid subjects were performed on admission and after L -thyroxine treatment when biochemical euthyroidism was achieved. Results: After a median period of 90 (90-210) days, 24 (19 females, 5 males) patients were euthyroid and eligible for a second color vision examination. Baseline tritan CCT and protan CCT values were significantly higher in the hypothyroid group compared to euthyroid controls, which clinically translates into impaired color contrast sensitivity (p < 0.001 and p < 0.001, respectively). There was a significant decrease in tritan CCT (p = 0.002) and protan CCT (p < 0.001) values in the hypothyroid group after euthyroidism was achieved, which denotes improvement in color contrast sensitivity. Conclusions: It is a novel finding of the current study that color contrast sensitivity is impaired in hypothyroidism and significantly improves after euthyroidism is achieved. (C) 2015 European Thyroid Association Published by S. Karger AG, BaselÖğe Hyperosmolar Nonketotic State Associated with Quetiapine(Galenos Yayincilik, 2014) Kaya, Ahmet; Turan, Elif; Ozlurk, Mine; Savut, Bulent; Kulaksizoglu, Mustafa; Gonulalan, GulsumA 67-year-old man was admitted to our hospital because of decreased oral intake and confusion. He had a 2-year history of diabetes mellitus and he had a good glycaemic control with oral antidiabetic drugs (latest HbA1C: 7.2%). Quetiapine was initiated 15 days ago in a psychiatric clinic because of depression. The patient was taken to the intensive care unit with the diagnosis of hyperosmolar nonketotic state and acute renal failure. All the medications were discontinued; intravenous hydration and insulin infusion were started. The relationship between secondgeneration antipsychotics (SGAs) and hyperglycemia is a topic of interest and insulin resistance is commonly accepted as the mechanism for hyperglycemia. Patients receiving SGAs should be followed more closely for metabolic disorders.Öğe Oxidant and antioxidant parameters in prediabetes and diabetes(Springer India, 2015) Erdem, Said Sami; Toker, Aysun; Kayrak, Mehmet; Cicekler, Humeyra; Gonulalan, Gulsum; Abdulhalikov, Turyan; Yerlikaya, Fatma HumeyraThe aim of our study was to evaluate serum paraoxonase (PON1), total antioxidant status (TAS), total oxidant status (TOS), and ischemia-modified albumin (IMA) levels in patients with prediabetes, diabetes, and in healthy control subjects. The subjects were aged between 20 and 60 years. Forty diabetic subjects (mean age 46.6 +/- 9.7 years), 39 prediabetic subjects (mean age 44.0 +/- 9.3 years) and 24 healthy control subjects (mean age 43.7 +/- 9.7 years). Lipid profile, PON1, TAS, TOS and IMA levels were measured. The serum TOS and IMA levels in diabetes were significantly higher than those of the control subjects (P=0.024 and P=0.012, respectively), while the serum PON1 levels of the diabetes patients were significantly lower than those of the control subjects (P=0.039). The serum TOS levels of the diabetes patients were significantly higher than those of the subjects with prediabetes (P=0.013). There were no significant differences between the serum IMA and PON1 levels of the prediabetes and diabetes groups (P=0.075 and P=0.110, respectively). The serum TAS levels of the three groups were similar. The present study demonstrated that in diabetes there is greater oxidative stress. Patients with type 2 diabetes had higher TOS and IMA levels, but lower PON1 values, than controls. There were no differences in oxidative stress markers between prediabetic patients and healthy subjects.