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    DOES PRIMARY TUMOR RESECTION AFFECT SURVIVAL IN ELDERLY PATIENTS WITH METASTATIC GASTRIC CANCER?
    (Gunes Kitabevi Ltd Sti, 2016) Yalcin Musri, Fatma; Mutlu, Hasan; Karaagac, Mustafa; Gunduz, Seyda; Karakurt Eryilmaz, Melek; Kivrak Salim, Derya; Tazegul, Gokhan
    Introduction: In this study, the effect of primary tumor resection (PTR) on the survival of patients with metastatic gastric carcinoma (mCG) aged over 65 years was aimed to be searched. Materials and Method: In total, 98 patients with mCG from the Akdeniz University, Necmettin Erbakan University, and Antalya Training and Research Hospital databases who were aged over 65 years were retrospectively evaluated. The patients were divided into two groups based on PTR: PTR (+) and PTR (-). Results: The median progression-free survival in the PTR (+) group was 10.2 months (95% confidence interval [CI] 6.6-13.7) and in the PTR (-) group was 5.9 months (95% CI 2.6-9.3) (p=0.054). When we evaluated the overall survival (OS) of the groups, the median OS was significantly higher in the PTR (+) group (11.5 months, 95% CI 8.4-14.6) than in the PTR (-) group (7.2 months, 95% CI 4.3-10.0) (p=0.001). In the final multivariate analysis, none of the parameters studied were independent prognostic factors. Conclusion: PTR may be beneficial for the survival of patients with mGC aged over 65 years.
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    Primary Tumor Resection and Survival in Patients with Stage IV Gastric Cancer
    (Korean Gastric Cancer Assoc, 2016) Musri, Fatma Yalcin; Mutlu, Hasan; Karaagac, Mustafa; Eryilmaz, Melek Karakurt; Gunduz, Seyda; Artac, Mehmet
    Purpose: The aim of this study was to determine whether surgical resection of the primary tumor contributes to survival in patients with metastatic gastric cancer. Materials and Methods: A total of 288 patients with metastatic gastric cancer from the Akdeniz University, Antalya Training and Research Hospital, and the Meram University of Konya database were retrospectively analyzed. The effect of primary tumor resection on survival of patients with metastatic gastric cancer was investigated using the log-rank test. Kaplan-Meier survival estimates were calculated. Multivariate analysis was performed using Cox proportional hazards regression modeling. Results: The median overall survival was 12.0 months (95% confidence intewrval [CI], 10.4 similar to 13.6 months) and 7.8 months (95% CI, 5.5 similar to 10.0 months) for patients with and without primary tumor resection, respectively (P<0.001). The median progression-free survival was 8.3 months (95% CI, 7.1 similar to 9.5 months) and 6.2 months (95% CI, 5.8 similar to 6.7 months) for patients with and without primary tumor resection, respectively (P=0.002). Conclusions: Non-curative gastrectomy in patients with metastatic gastric cancer might increase their survival rate regardless of the occurrence of life-threatening tumor-related complications.