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Öğe Behçet Hastalığında İyatrojenik Sağ İnternal Mamaryan Arter Çalma Sendromu(2014) Erol, Cengiz; Paksoy, Yahya; Kanat, Fikret; Özbek, Seda; Kıvrak, Ali Sami; Koplay, Mustafa; Özbek, OrhanSubklaviyan arter anevrizması nedeniyle opere edilen bir Behcet olgusunda anevrizmaya açılan vertebral arter ve sağ internal mamaryan arterin, anevrizma kesesi içerisinde bırakılması sonucu, post operatif dönemde iatrojenik olarak ortaya çıkan sağ internal mamaryan arter çalma sendromunun görüntüleme bulgularını sunmak istedik. Bizim bilgilerimize göre bugüne kadar, sağ internal mamaryan arterin sorumlu olduğu çalma sendromu literatürde tariflenmemiştir. Kesitsel noninvaziv radyolojik görüntüleme yöntemleri, bu olguda anatomik detayın gösterilmesi, cerrahi sonrası değişen ve yeni ortaya çıkan anatominin ortaya konmasında oldukça başarılı olmuştur.Öğe Correlation of myeloid-derived suppressor cells with C-reactive protein, ferritin and lactate dehydrogenase levels in patients with severe COVID-19(Wiley, 2022) Emsen, Ayca; Sumer, Sua; Tulek, Baykal; Cizmecioglu, Hilal; Vatansev, Husamettin; Goktepe, Mevlut Hakan; Kanat, FikretThe novel coronavirus disease 2019 (COVID-19) remains a global health emergency, and understanding the interactions between the virus and host immune responses is crucial to preventing its lethal effects. The expansion of myeloid-derived suppressor cells (MDSCs) in COVID-19, thereby suppressing immune responses, has been described as responsible for the severity of the disease, but the correlation between MDSC subsets and COVID-19 severity remains elusive. Therefore, we classified patients according to clinical and laboratory findings-aiming to investigate the relationship between MDSC subsets and laboratory findings such as high C-reactive protein, ferritin and lactate dehydrogenase levels, which indicate the severity of the disease. Forty-one patients with COVID-19 (26 mild and 15 severe; mean age of 49.7 +/- 15 years) and 26 healthy controls were included in this study. MDSCs were grouped into two major subsets-polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs-by flow cytometric immunophenotyping, and PMN-MDSCs were defined as mature and immature, according to CD16 expressions, for the first time in COVID-19. Total MDSCs, PMN-MDSCs, mature PMN-MDSCs and monocytic MDSCs were significantly higher in patients with COVID-19 compared with the healthy controls (P < .05). Only PMN-MDSCs and their immature PMN-MDSC subsets were higher in the severe subgroup than in the mild subgroup. In addition, a significant correlation was found between C-reactive protein, ferritin and lactate dehydrogenase levels and MDSCs in patients with COVID-19. These findings suggest that MDSCs play a role in the pathogenesis of COVID-19, while PMN-MDSCs, especially immature PMN-MDSCs, are associated with the severity of the disease.Öğe The Relationship between COVID-19 Severity and Bacillus Calmette-Guerin (BCG)/ Mycobacterium tuberculosis exposure history in healthcare workers: a multi-center study(Taylor & Francis Ltd, 2021) Torun, Serife; Ozkaya, Sevket; Sen, Nazan; Kanat, Fikret; Karaman, Irem; Yosunkaya, Sebnem; Sengoren Dikis, OzlemThe COVID-19 pandemic has brought countries' health services into sharp focus. It was drawn to our group's attention that healthcare workers (HCWs) had a lower mortality rate against higher COVID-19 incidence compared to the general population in Turkey. Since risk of exposure to tuberculosis bacillus among healthcare workers are higher than the population, we aimed to investigate if there is a relationship between BCG and Mycobacterium tuberculosis exposure history with COVID-19 severity in infected HCWs. This study was conducted with 465 infected HCWs from thirty-three hospitals to assess the relationship between COVID-19 severity (according to their hospitalization status and the presence of radiological pneumonia) and BCG and Mycobacterium tuberculosis exposure history. HCWs who required hospital admission had significantly higher rates of chronic diseases, radiological pneumonia, and longer working hours in the clinics. Higher rates of history of contact and care to tuberculosis patients, history of tuberculosis, and BCG vaccine were observed in hospitalized HCWs. HCWs who had radiological pneumonia had a significantly increased ratio of history of care to tuberculosis patients and a higher family history of tuberculosis. The findings from our study suggest that the lower mortality rate despite the more severe disease course seen in infected HCWs might be due to frequent exposure to tuberculosis bacillus and the mortality-reducing effects of the BCG vaccine.Öğe Serum C-reactive protein and procalcitonin levels in non-small cell lung cancer patients(European Respiratory Soc Journals Ltd, 2012) Tulek, Baykal; Koylu, Habibe; Kanat, Fikret; Arslan, Ugur; Ozer, Faruk[Abstract Not Availabe]
