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Öğe Evaluation of oxidant/anti-oxidants status in patients with mild acute pancreatitis(Univ Catholique Louvain-Ucl, 2016) Baser, Husniye; Can, Ummugulsum; Karasoy, Deniz; Ay, Abdulhalim Serden; Baser, Salih; Yerlikaya, Fatma Humeyra; Ecirli, SamilBackground and aim : Acute pancreatitis (AP), an inflammatory disorder of the pancreas, is associated with significant morbidity and mortality. The pathogenesis of AP has been suggested to involve high oxidative stress (OS), combined with inadequate antioxidant status. We aimed to investigate the levels of serum total anti-oxidant status (TAS), total oxidant status (TOS) and ischemia-modified albumin (IMA) in patients with mild AP. Methods : Thirty subjects with mild AP and 29 healthy controls were enrolled into the study. The levels of TAS, TOS and IMA, Creactive protein (CRP), high sensitivity CRP (hs-CRP) and fibrinogen were measured in both groups. Results : TAS levels were significantly lower (p = 0.037), while IMA levels were significantly higher (p < 0.001) in patients, compared to controls. TOS levels were similar between two groups. Fibrinogen, CRP and hs-CRP levels were significantly higher in patients than those of controls (p < 0.001 for all parameters). IMA levels were positively correlated with amylase and lipase levels (r = 0.448, p = 0.001 and r = 0.469, p < 0.001, respectively). There was a negative correlation between TAS levels, and amylase and lipase levels (r = -0.277, p = 0.035 and r = -0.278, p = 0.034, respectively). Conclusions : OS is reported to be associated with the inflammatory process and the severity of AP. In our study, among OS parameters, an increase in IMA levels and a decrease in TAS levels were observed in mild AP patients.Öğe SERUM UROKINASE-TYPE PLASMINOGEN ACTIVATOR RECEPTOR IN PATIENTS WITH ACUTE PANCREATITIS(Nobel Ilac, 2021) Can, Ummugulsum; Baser, Salih; Yerlikaya, Fatma Humeyra; Karasoy, DenizObjective: Acute pancreatitis (AP) is an inflammatory disease in which digestive enzymes produced by pancreas destroy the gland via protease pancreatic au todigestion. Soluble urokinase-type plasminogen activator receptor (suPAR), an inflammatory biomarker, is responsible for various immunological functions, including inflammation, cell adhesion, migration and proteolysis. The main goal of our study was to evaluate serum suPAR level in patients with mild AP, compared with controls. Material and Method: The study was performed on 40 patients with mild AP and 50 healthy controls. Controls were matched with patients as to age and body mass index (BMI). The diagnosis of AP was established under the Ranson criteria. Serum suPAR levels were measured through ELISA method. Results: Serum suPAR levels of patients were significantly higher than those of control subjects (4.81 +/-.3.30; 1.98 +/- 1. 78 ng/ml, respectively) (p<0.001). No significant correlation was found between suPAR levels, amylase, lipase, CRP, hs-CRP and fibrinogen levels (p>0.05 for all parameters). Conclusion: Our study indicated that serum suPAR may play an important role in the inflammatory process in AP, and suPAR could be used as a clinically beneficial marker in the diagnosis of AP.