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Öğe Chronic Inflammation-Related Diffuse Large B-Cell Lymphoma Around the Area of Thoracotomy After Decortication(Derman Medical Publ, 2014) Metin, Bayram; Sahin, Sevinc; Ede, Huseyin; Kaya, Bugra; Erkoc, Mustafa FatihChest wall tumors consist 5% of all tumors in the thorax. Lymphomas compose of less than 5% of all primary chest wall malignancy. Sixty three years old patient who had an operation for pleural thickness two years ago admitted with complaint of left-sided chest pain. Following the detection of mass lesion radiologically at the place of previous operation area, the patient was operated based on needle biopsy result suggesting Ewing /PNET or pulmonary originated tumor. After the operation, pathological examination confirmed chronic inflammation-related diffuse large B-cell lymphoma. Since it has been rarely reported in the literature, we aimed to present the case of chronic inflammation-related diffuse large B-cell lymphoma developed within such a short time as two years on the ground of surgical incision scar tissue together with our radiologic, surgical, and pathological findings.Öğe DETERMINING THE ATTITUDES TOWARDS HEALTH INFORMATION TECHNOLOGIES: A STUDY IN A UNIVERSITY HOSPITAL(Mehmet Akif Ersoy Univ, 2022) Kaya, Bugra; Ileri, Yusuf YalcinThe aim of the study is to determine hospital workers' attitudes towards health information technologies (HIT) and to examine whether their expectations and usage levels of HIT are significant when compared with the descriptive variables in terms of HIT dimensions. In the study, the Use of Health Information Technologies dimension which is the sub-dimension of the Attitude Scale towards Health Information Technologies Use was utilized. This dimension also has 6 sub-dimensions. Confirmatory factor analysis, normality, reliability, percentage, mean, standard deviation, t test and ANOVA test were used to analyze the data. Study findings presents a significant difference between the hospital workers' occupational status variable and the sub-dimensions of intention of use, self-efficacy, and expectation from HIT (p<0.05). A significant difference was found between the groups of hospital workers in the age variable and the IT staff support and HIT infrastructure sub-dimensions (p<0.05). Similarly, a significant difference was found between the groups in the working time variable of hospital workers in the dimensions of IT staff support, HIT Infrastructure, intention of use, HIT selection and expected participation in the design process and (p<0.05). Study results show that hospital workers' intentions and expectations of using HIT were high but their self-efficacy was low. It is recommended that communication channels should be kept open for hospital workers to receive rapid technical support from IT staff for the problems they experience with HIT and regular HIT trainings should be organized to increase their self-efficacy.Öğe Effect of R-CHOP chemotherapy on liver and mediastinal blood pool 18F-FDG standardized uptake values in patients with non-Hodgkin's lymphoma(Elsevier Science Inc, 2015) Kaya, Bugra; Dostbil, Zeki; Ismailoglu, Murat; Tasdemir, Bekir; Sahin, OzlemAim: We aimed to investigate the impact of chemotherapy on F-18-FDG uptake in the liver and mediastinal blood pool (MBP) among patients with non-Hodgkin's lymphoma. Methods: Twenty-three patients with NHL underwent baseline, interim, and postchemotherapy F-18-FDG PET/CT. SUVmax and SUVmean values of the liver and MBP at imaging time were compared statistically. Results: We did not find any significant differences between the liver and mediastinum SUVmean and SUVmax values (P>.05). Conclusions: Our study demonstrates that the F-18-FOG uptake in the liver and MBP are not significantly affected by R-CHOP chemotherapy in patients with NHL. (C) 2015 Elsevier Inc. All rights reserved.Öğe Erlotinib Response in a Non-Small Cell Lung Cancer Patient with EGFR Exon 20 Mutation(Akad Doktorlar Yayinevi, 2016) Korkmaz, Levent; Artac, Mehmet; Karaagac, Mustafa; Er, Zehra; Boruban, Melih C.; Poyraz, Necdet; Kaya, Bugra[Abstract Not Availabe]Öğe F-18 fdg pet/ct imaging in a patient presenting with mediastinal lymphadenopathies: a case of sarcoidosis(Drunpp-Sarajevo, 2012) Dostbil, Zeki; Kaya, Bugra; Sari, Oktay; Varoglu, ErhanF-18 FDG PET/CT has been used increasingly in evaluation of pulmonary and mediastinal lesions. However, inflammatory and granulomatous disorders may show increased F-18 FDG uptake on PET scanning. So, some benign conditions may cause false-positive results in cancer investigation. In this case, F-18 FDG PET/CT findings were presented in a patient with sarcoidosis who was investigated for primarily suspected malignancy.Öğe Hot Lung Sign in Pulmonary Intravascular Large B-Cell Lymphoma on 18F-FDG PET/CT(Lippincott Williams & Wilkins, 2020) Sahin, Ozlem; Kaya, Bugra; Serdengecti, Mustafa; Cizmecioglu, Hilal Akay; Sen, Ahmet ErenIntravascular large B-cell lymphoma is a rare type of non-Hodgkin lymphoma characterized by intravascular proliferation of clonal lymphocytes within the lumen of small vessels, which is often fatal. Diffuse FDG uptake in the lung without clear/evident CT findings, hot lung, is quasi-pathognomonic for lung intravascular large B-cell lymphoma. In this report, we present the case of a 43-year-old man who was diagnosed as having intravascular lymphoma thanks to this rare finding.Öğe Imaging Features of Breast Plasmacytoma(Galenos Publ House, 2022) Babaoglu, Seyma; Poyraz, Necdet; Kaya, Bugra; Findik, Siddika; Demircioglu, Sinan[Abstract Not Availabe]Öğe Late PET/CT Findings of COVID-19 Pneumonia With 2 Different Radiopharmaceuticals in a Patient PSMA Avidity Higher Than FDGs(Lippincott Williams & Wilkins, 2021) Sahin, Ozlem; Kaya, Bugra; Aydin, Zeynep; Karaagac, Mustafa; Kanyilmaz, GulWe present the Ga-68-PSMA and F-18-FDG PET/CT findings comparatively of a 67-year-old prostate cancer and malignant melanoma patient who had COVID-19 pneumonia 3 months ago. In Ga-68-PSMA PET/CT, ground-glass opacities showing markedly increased PSMA uptake were observed in the patient's lungs. It was learned that the patient had COVID-19 pneumonia 3 months ago and was treated in the intensive care unit for 13 days. In F-18-FDG PET/CT, FDG uptake was minimal in the same areas. In the midterm period after COVID-19 pneumonia, lung PSMA uptake is more intense than FDG, which may help better understand the disease's healing phase.Öğe Our transthoracic biopsy practices accompanied by the imaging process: The contribution of positron emission tomography usage to accurate diagnosis(Taylor & Francis Ltd, 2016) Intepe, Yavuz Selim; Metin, Bayram; Sahin, Sevinc; Kaya, Bugra; Okur, AylinObjectives: The objective of this study was to compare the results of transthoracic biopsies performed through the use of FDG PET/CT imaging with the results of transthoracic needle biopsy performed without using the FDG PET/CT imaging.Methods: The medical files of a total of 58 patients with pulmonary and mediastinal masses. A total of 20 patients, who were suspected of malignancy with the SUVmax value of over 2.5 in FDG PET/CT, underwent a biopsy process. Twelve patients with no suspicion of malignancy in accordance with CT images and with the SUVmax value below 2.5 underwent no biopsy procedure, and hence, they were excluded from the study. On the other hand, 26 patients directly went through a biopsy process with the suspicion of malignancy according to CT imaging, regardless of performing any FDG PET/CT imaging.Results: According to the biopsy results, the number of the patients diagnosed with cancer was 20 (43.5%), while the number of non-cancerous patients was 26 (56.5%). When these findings were considered, it was determined that the sensitivity of the whole TTNB (transthoracic needle biopsy) was 80.8%, and the specificity was found as 100%. The positive predictive value of the whole TTNB was 100%, while its negative predictive value was found to be 80%. The sensitivity in TTNB performed together with FDG PET/CT was 90.9%, whereas the specificity was 100%. The positive predictive value of TTNB with FDG PET/CT was 100%, while its negative predictive value was found to be 81.8%. The sensitivity in TTNB performed without the use of FDG PET/CT was 73.3%, whereas the specificity was determined as 100%.Conclusions: Performing FDG PET/CT imaging process prior to a transthoracic biopsy as well as preferring FDG PET/CT for the spot on which the biopsy will be performed during the transthoracic biopsy procedure increases the rate of receiving accurate diagnosis.Öğe Prognostic significance of adipose tissue distribution and metabolic activity in PET-CT images of patients with metastatic colorectal cancer.(Lippincott Williams & Wilkins, 2020) Karacelik, Tuba; Kaya, Bugra; Karaagac, Mustafa; Araz, Murat; Bozcuk, Hakan Sat; Artac, Mehmet[Abstract Not Availabe]Öğe Prognostic Significance of Adipose Tissue Distribution and Metabolic Activity in PET/CT in Patients with Metastatic Colorectal Cancer(Springer, 2023) Karacelik, Tuba; Kaya, Bugra; Korkmaz, Mustafa; Karaagac, Mustafa; Araz, Murat; Eryilmaz, Melek Karakurt; Bozcuk, Hakan SatPurpose In this study, we aimed to evaluate the prognostic significance of adipose tissue distribution and metabolic activity in PET/CT to predict survival in patients with metastatic colorectal cancer (mCRC). Methods The volume, density (HU), and FDG uptake (standardized uptake value (SUV)) of visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and maximum FDG uptake of the tumor tissue were measured. Subcutaneous adipose tissue of volume-to-density ratio (SAT ratio) was calculated. Results The median OS for the patients with SAT ratio value < -1.1 and >= -1.1 were 38.5 (95% CI 31.54-45.58) and 24.5 (95% CI 14.13-34.93) months, respectively (p = 0.05). During follow-up, 69 patients experienced disease progression. The median progression-free survival (PFS) was 11.03 months (95% CI: 9.11-12.95). Median PFS for patients with tumor SUV max value < 11.5 and >= 11.5 were 9.2 (95% CI 7.25-11.27) and 12.6 (95% CI 10.02-15.27) months, respectively (p = 0.14). Forty-eight patients received bevacizumab therapy. VAT SUV mean (HR: 0.09; 95% CI 0.01-0.52, p = 0.008) was significantly associated with PFS in patients receiving bevacizumab. SAT ratio was the significant parameter for the OS (HR: 0.58; 95% CI 0.33-1.01, p = 0.05) and PFS (HR: 1.99; 95% CI 1.02-3.91, p = 0.043). Conclusions SAT ratio was an independent prognostic factor for survival in patients with mCRC. Higher SAT volume is correlated with longer survival in mCRC patients.Öğe The prognostic significance of the 18F-fluorodeoxyglucose positron emission tomography/computed tomography in early-stage nonsmall cell lung cancer(Wolters Kluwer Medknow Publications, 2020) Geredeli, Caglayan; Artac, Mehmet; Kocak, Ismail; Koral, Lokman; Sakin, Abdullah; Altinok, Tamer; Kaya, BugraContext: The prognostic criteria for early-stage nonsmall cell lung cancer (NSCLC) wait to be explored. Aim: In this study, our aim was to evaluate the prognostic significance of the positron emission tomography/computed tomography (PET/CT) maximum standardized uptake value (SUVmax) value of the primary tumor in patients with a diagnosis of early-stage NSCLC who received surgical treatment. Settings and Design: This was a multicenter retrospective design. Materials and Methods: Patients who had been diagnosed with early-stage NSCLC and who underwent surgery for the condition were included in this study. The preoperative fluorodeoxyglucose (18F-FDG) PET/CT results of the patients were retrospectively accessed from their medical files. The disease-free survival (DFS) rates of patients who had SUVmax values above and below the determined cutoff value were compared. Statistical Analysis Used: SPSS version 22 and Kaplan-Meier method were used for statistical analysis. Results: A total of 92 patients were included in the study. The median age of the patients was 60 years (range: 36-79). The determined cutoff SUVmax value of the primary tumor was 13.6. A comparison of the DFS rates of the patients with an SUVmax value above and below 13.6 revealed a significant difference in patients with Stage I (22.9 months vs. 50.3 months; P = 0.02) and Stage II (28 months vs. 40.4 months; P = 0.04), Stage I + II (43.5 months vs. 26.1 months; P = 0,02), and Stage IIIA (14.7 months vs. 13.6 months; P = 0.92) NSCLC. Conclusions: We found that in early-stage NSCLC patients, the SUVmax value of the primary mass in 18F FDG PET/CT was a prognostic indicator for the DFS rates.Öğe Prostate incidentaloma on 18F-fluorodeoxyglucose positron emission tomography: Diagnostic value of volumetric positron emission tomography parameters(Georg Thieme Verlag Kg, 2021) Sahin, Ozlem; Kaya, Bugra; Aydin, Zeynep; Sen, Ahmet Eren; Iyisoy, Mehmet Sinan; Aydin, ArifObjective To evaluate whether volumetric PET parameters such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) contributed to maximum standardized uptake value (SUVmax) in predicting prostate carcinoma in the prostate incidentalomas (PI) in 18F-FDG PET/CT. Materials and methods This retrospective study comprised 107 patients with PI of 4723 male patients who had undergone 18F-FDG PET/CT. SUVmax and volumetric PET parameters of PIs were assessed. MTV and TLG were acquired with each SUV threshold as 2.5, 3.0, 3.5, 4.0, 4.5, and 5.0. Results The PI incidence was 2.3 %, and the malignancy ratio of PI was 15.9 %. According to further analysis results, 17 patients were in the malignant group, and 46 patients were in the benign group. Malignant PIs had higher SUVmax (10.6 vs. 6.4 and p < 0.01), MTV (all p < 0.01) and TLG (all p < 0.01) than benign incidentalomas. All volumetric PET parameters had higher area under the curve (AUC) than SUVmax. SUVmax AUC was 0.835 [95 % confidence interval (CI): 0.728-0.942]. MTV 2.5 and TLG 2.5 had the highest performance for predicting malignant PI. MTV2.5 AUC was 0.871 (95 % CI: 0.775-0.968), and TLG2.5 AUC was 0.882 (95 % CI: 0.797-0.967). Using TLG 2.5 greater than 29.8 as the cut-off point, the sensitivity and specificity for malignancy prediction were 94.1 % and 82.6 %, respectively. Conclusion In this study, in which the effectiveness of volumetric parameters in the diagnosis of PI was evaluated for the first time, it was shown that they could potentially have clinical value along with SUVmax.Öğe A Rare Case of Pulmonary Alveolar Microlithiasis with Diffuse Lung Uptake on Bone Scintigraphy(Galenos Publ House, 2022) Sen, Ahmet Eren; Sahin, Ozlem; Aydin, Zeynep; Kaya, Bugra; Erol, Caglagul[Abstract Not Availabe]
