Yazar "Kaya, Zeynettin" seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Akut pulmoner emboli tanısı alan hastalarda çözünebilir CD40 ligand düzeyi ve ekokardiyografik parametreler(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2010) Kaya, Zeynettin; Özdemir, KurtuluşBu çalışmamızda, hayatı tehdit edici ve görece sık karşılaşılan acil bir kardiyovaskuler patoloji olan akut PE'nin patogenezini daha fazla aydınlatabilmek, erken tanı ve risk sınıflamasına katkıda bulunabilmek amacıyla özellikle enflamasyon ve tromboz ile ilişkili çCD40L düzeylerinin akut PE hastalarında benzer demografik özelliklere sahip olan kontrol grubu ile kıyaslanması hedeflenmiştir. Bunun yanında Akut PE hastalarında konvansiyonel ve doku Doppler ekokardiyografik parametrelerindeki farklılıklar ve bunların çCD40L değerleri ile ilişkisi araştırılmıştır.Metod: Tanımlayıcı ve kesitsel çalışmamıza, Ocak 2010 ve Temmuz 2010 tarihleri arasında Selçuk Üniversitesi Meram Tıp Fakültesi Hastanesi'nde akut PE tanısı konan 65 hasta ve hastalar ile benzer demografik özellikleri ve komorbiditeleri olan sağlıklı 29 gönüllü dâhil edildi. Hastaların tümünün, kontrol grubunun 21'nin çCD40L değerleri ELİSA yöntemi ile eBioscience (BenderMed Systems, Avusturya) kiti kullanılarak çalışıldı. Hasta ve kontrol grubunun geleneksel iki boyutlu ve Doppler ekokardiyografik verileri yanında doku Doppler ekokardiyografik parametreleri kaydedildi. Hasta ve kontol grubunda elde edilen değişkenler karşılaştırıldı.Bulgular: Hasta ve kontrol grupları arasında demografik özellikler ve komorbiditeler açısından istatiksel farklılık yoktu. çCD40L düzeyinin akut PE hastalarında (5.3 ng/ml), kontrol grubuna(1.4 ng/ml) göre istatiksel olarak anlamlı düzeyde artmış olduğu görüldü (P<0.001). çCD40L kestirim değeri 0.7 ng/ml olarak alındığında PE olgularını tanıma yönünden duyarlılık 0.71, özgüllük 0.52, pozitif tahmin değeri 0.82, negatif tahmin değeri 0.37 ve tanısal doğruluğu 0.65 olarak hesaplandı. çCD40L değerleri ile akut PE ciddiyetinin göstergesi olan ekokardiyografi parametreler arasında istatiksel anlamlı ilişki izlenmedi. Hasta grubunda SğV EF belirgin düşük (46.2 karşı 60.5 P<0.001), PAB anlamlı yükek (45 mmHg karşı 24.7 mmHg P<0.001) ve İVC kollaps indeksi istatiksel anlamlı düzeyde düşük (0.36 karşı 0.62 P<0.001) tespit edildi. Pulsed wave doku Doppler tekniği ile değerlendirilen SğV MPİ'nin akut PE hastalarında kontrol grubuna göre alamlı düzeyde arttığı (0.53 karşı 0.43 P<0.001), SğV E/Em oranının anlamlı olarak daha yüksek olduğu (6.5 karşı 5,0 P: 0.04) ve SğV İVRZ'nin anlamlı şekilde uzadığı(67msn karşı 57msn P<0.001) tespit edildi.Sonuç: çCD40L daha önce yapılan çalışmalarda aterotromboz ve enflamasyonda gösterilmiş olan rolü yanında venöz tromboz patogezinde de rolü olduğu, ilk olarak gösterilmiştir. Prediktif ve prognostik değeri açısından ileri çalışmalara ihtiyaç duyulmaktadır. Bunun yanında özellikle SğV EF, İVC kollpaps indeksi, Sm, MPİ, E/Em gibi ekokardiyografik parametreler PE olgularının tanısında kullanılabilecek değişkenler olarak tespit edilmiştir.Öğe The Association Between Peri-aortic Fat and Long-term Incidence of Major Adverse Cardiovascular Events(Elsevier Science Inc, 2013) Kaya, Zeynettin; Ulucan, Seref; Katlandur, Huseyin; Keser, Ahmet; Tuncez, Abdullah; Alihanoglu, Yusuf Izzettin; Efe, Duran[Abstract Not Availabe]Öğe The association between thoracic periaortic fat and major adverse cardiovascular events(Springer Wien, 2015) Kaya, Zeynettin; Ulucan, Seref; Kayrak, Mehmet; Akyurek, Omer; Katlandur, Huseyin; Keser, Ahmet; Efe, DuranThe study aimed to examine the association between thoracic periaortic fat tissue volume and the long-term incidence of major adverse cardiovascular events. This retrospective cohort study included 433 consecutive patients (372 male and 61 female). Periaortic fat tissue volume was measured via electrocardiogram-gated 64-multidetector computed tomography. The patients were evaluated on an average 3 years of follow-up for major adverse cardiovascular events. The patients were divided into groups according to the presence of major adverse cardiovascular events. Major adverse cardiovascular events were noted in 44 (10.2 %) patients during follow-up. Periaortic fat tissue volume was significantly higher in the major adverse cardiovascular events (+) group (35.4 +/- A 26.1 cm(3) vs. 24.1 +/- A 14.9 cm(3), P = 0.001). The logistic regression model showed that periaortic fat tissue volume (hazard ratio: 1.03; 95 % CI: 1.01-1.05; P = 0.001), the glomerular filtration rate (hazard ratio: 0.98; 95 % CI: 0.96-0.99; P = 0.03), and male gender (hazard ratio: 4.76; 95 % CI: 1.08-20.90; P = 0.04) were independent predictors of major adverse cardiovascular events. Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.Öğe Clinical Characteristics and Outcome of Cardiovascular Implantable Electronic Device Infections in Turkey(Sage Publications Inc, 2016) Aydin, Mesut; Yildiz, Abdulkadir; Kaya, Zeynettin; Kaya, Zekeriya; Basarir, Ahmet Ozgur; Cakmak, Nazmiye; Donmez, IbrahimInfection is one of the most devastating outcomes of cardiovascular implantable electronic device (CIED) implantation and is related to significant morbidity and mortality. In our country, there is no evaluation about CIED infection. Therefore, our aim was to investigate clinical characteristics and outcome of patients who had infection related to CIED implantation or replacement. The study included 144 consecutive patients with CIED infection treated at 11 major hospitals in Turkey from 2005 to 2014 retrospectively. We analyzed the medical files of all patients hospitalized with the diagnosis of CIED infection. Inclusion criteria were definite infection related to CIED implantation, replacement, or revision. Generator pocket infection, with or without bacteremia, was the most common clinical presentation, followed by CIED-related endocarditis. Coagulase-negative staphylococci and Staphylococcus aureus were the leading causative agents of CIED infection. Multivariate analysis showed that infective endocarditis and ejection fraction were the strongest predictors of in-hospital mortality.Öğe Deterioration of heart rate recovery index in patients with erectile dysfunction(2016) Ulucan, Şeref; Kaya, Zeynettin; Keser, Ahmet; Katlandur, Hüseyin; Karanfil, Mustafa; Ateş, İsmailObjective: Heart rate recovery (HHR) after exercise is a function of vagal reactivation. This study aimed to evaluate HHR index in patients with erectile dysfunction.Methods: Men over the age of 18 years who were diagnosed with erectile dysfunction were included in the study. Ninety patients with erectile dysfunction (mean age56.1±8.3 years) and 50 healthy subjects as controls (mean age53.1±10.4 years) were compared. The erectile status of patients was evaluated using the sexual health inventory for men questionnaire. Basal electrocardiography, echocardiography, and treadmill exercise testing were performed in all patients and controls. The HHR index was defined as the reduction in heart rate from the rate at peak exercise to the rate at the first minute (HRR), second minute (HRR), third minute (HRR), and fifth minute (HRR) after terminating exercise stress testing. An independent sample t-test, Pearson correlation coefficient test, linear multivariate regression analysis, and receiver operating characteristic curve analysis were used for statistical assessment.Results: All HHR indices were found to be significantly decreased in patients with erectile dysfunction (p>0.001). Effort capacity was markedly lower (9.1±2.3 vs. 10.4±2.3 METs, p0.002) among patients with erectile dysfunction. HRR and HRR were found to be an independent risk factor for erectile dysfunction (Beta0.462, p>0.001; Beta0.403, p>0.001; respectively) in linear regression analysis.Conclusion: Decreased HHR index may be considered as one of the independent predictors of impaired autonomic function in patients with erectile dysfunction.Öğe The relationship between white coat hypertension and sleep quality(Springer Japan Kk, 2014) Kaya, Zeynettin; Kayrak, Mehmet; Demir, Kenan; Gunduz, Mehmet; Alibasic, Hayruddin; Karanfil, Mustafa; Akilli, HakanImpaired sleep quality is frequently associated with hypertension. The present study aims to examine self-reported sleep quality of patients with white coat hypertension. A total of 74 subjects who were evaluated in a cardiology outpatient clinic, including 39 normotensive subjects and 35 patients with white coat hypertension between the ages of 20 and 65 were included in this study. Patients with elevated office blood pressure (>= 140/90 mm Hg) and normal 24-h and daytime ambulatory blood pressure (<125/80 mm Hg and <130/85 mm Hg, respectively) were defined as white coat hypertension. Patient's sleep quality was evaluated using the Pittsburgh sleep quality index. Global Pittsburgh sleep quality index score was significantly higher in patients with white coat hypertension than normotensive subjects (7.2 +/- 3.7 vs. 5.1 +/- 3.8, P = 0.01). Poor sleep quality was present in 65% of patients with white coat hypertension, and in 30% of the normotensive group (P = 0.003). A multiple logistic regression analysis showed that white coat hypertension (odds: 6.7 (95% confidence interval [CI] 1.22-36.64), P = 0.03) and female gender (odds: 10.1(95% CI 1.35-76.32), P = 0.02) were independent predictors of poor sleep quality. In conclusion, white coat hypertension seems to be associated with impaired sleep quality.Öğe Renal Drug Dosage Adjustment According to Estimated Creatinine Clearance in Hospitalized Patients With Heart Failure(Lippincott Williams & Wilkins, 2016) Altunbas, Gokhan; Yazici, Mehmet; Solak, Yalcin; Gul, Enes E.; Kayrak, Mehmet; Kaya, Zeynettin; Akilli, HakanIt is of clinical importance to determine creatinine clearance and adjust doses of prescribed drugs accordingly in patients with heart failure to prevent untoward effects. There is a scarcity of studies in the literature investigating this issue particularly in patients with heart failure, in whom many have impaired kidney function. The purpose of this study was to determine the degree of awareness of medication prescription as to creatinine clearance in patients hospitalized with heart failure. Patients hospitalized with a diagnosis of heart failure were retrospectively evaluated. Among screened charts, patients with left ventricular ejection fraction,40% and an estimated glomerular filtration rate (eGFR) of <= 50 mL/min were included in the analysis. The medications and respective doses prescribed at discharge were recorded. Medications requiring renal dose adjustment were determined and evaluated for appropriate dosing according to eGFR. A total of 388 patients with concomitant heart failure and renal dysfunction were included in the study. The total number of prescribed medications was 2808 and 48.3% (1357 medications) required renal dose adjustment. Of the 1357 medications, 12.6% (171 medications) were found to be inappropriately prescribed according to eGFR. The most common inappropriately prescribed medications were famotidine, metformin, perindopril, and ramipril. A significant portion of medications used in heart failure requires dose adjustment. Our results showed that in a typical cohort of patients with heart failure, many drugs are prescribed at inappropriately high doses according to creatinine clearance. Awareness should be increased among physicians caring for patients with heart failure to prevent adverse events related to medications.Öğe The Role of Ischemia Modified Album in Acute Pulmonary Embolism(Elsevier Science Inc, 2013) Kaya, Zeynettin; Kayrak, Mehmet; Gul, Enes Elvin; Altunbas, Gokhan; Toker, Aysun; Kiyici, Aysel; Gunduz, Mehmet[Abstract Not Availabe]Öğe White Coat Hypertension and Poor Sleep Quality(Elsevier Science Inc, 2013) Kaya, Zeynettin; Kayrak, Mehmet; Demir, Kenan; Gunduz, Mehmet; Alibasic, Hayruddin; Karanfil, Mustafa; Akilli, Hakan[Abstract Not Availabe]
