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Öğe Bir üniversite hastanesinde yatarak tedavi gören hastalarda depresyon ve anksiyete bozukluklarının yaygınlığı(Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi, 2011) Kayhan, Fatih; Kucur, RahimBu çalışmada hastanede yatarak tedavi gören hastalarda depresyon ve anksiyete bozukluklarının yaygınlığını saptamayı, sosyodemografik faktörler, tıbbi hastalıklar ve uygulanan tedaviler arasındaki ilişkiyi ortaya koymayı amaçladık.Çalışmaya psikiyatri ve çocuk hastalıkları servisleri dışında yatarak tedavi gören 650 hasta basit rastgele örneklem yöntemiyle seçilerek dahil edildi. Dışlama kriterleri sonucunda 57 hasta çalışma dışı bırakıldı. Depresyon ve anksiyete bozukluklarının şiddetini değerlendirmek için HAM-D ve HAM-A ölçekleri kullanıldı. Depresyon ve anksiyete bozukluklarının tanılarını değerlendirmek için SCID-I/CV kullanıldı.Tüm örneklem ele alındığında, olguların %37,5'inde (s=226) bir psikiyatrik bozukluk, %14,3'ünde (s=86) bir duygudurum bozukluğu, %23,2'sinde (s=140) bir anksiyete bozukluğu, %2,3'ünde (s=14) alkol kullanım bozukluğu saptandı. Lojistik regresyon analizi sonuçlarımıza göre ise yatan hastalarda kadın cinsiyet ve geçirilmiş bireysel psikiyatrik öykü psikiyatrik bozukluk ile ilişkili bağımsız ilişkili etkenler olarak bulundu.Bulgularımız psikiyatrik bozuklukların hastanede yatarak tedavi gören ve kronik hastalığı olan bireylerde sağlıklı nüfusa göre daha sık olduğunu göstermektedir. Bireysel psikiyatrik bozukluk öyküsü olanlarda, kadınlarda depresyon ve anksiyete bozuklukları daha sık görülmekte ve hastalar için bir risk faktörü olarak görünmektedir. Psikiyatrik bozukluklar, yatan hastalarda sık görülmesine rağmen sağlık ekibi tarafından yeterince tanınamamakta ve tedavi edilemeğini düşündürmektedir. Erken dönemde tanınamayan ve tedavi edilmeyen psikiyatrik bozuklukların, hastaların hastanede yatış süresini uzattığı, sık hastane yatışlarına, sosyal ve maddi yönden kayıplara neden olduğu düşünülebilir.Öğe Bupropion XL-Induced Motor and Vocal Tics(Lippincott Williams & Wilkins, 2014) Kayhan, Fatih; Uguz, Faruk; Kayhan, Aysegul; Toktas, Fikriye IlayTics are stereotypical repetitive involuntary movements (motor tics) or sounds (vocal tics). Although the emergence of tics were reported in a few cases with the use of selective serotonin reuptake inhibitors, there was no case with bupropion extended-release (Bupropion XL). The current case report presents a male patient developing motor and vocal tics with the use of bupropion XL.Öğe Mood and anxiety disorders among inpatients of a university hospital in Turkey(Elsevier Science Inc, 2013) Kayhan, Fatih; Cicek, Erdinc; Uguz, Faruk; Karababa, Ibrahim Fatih; Kucur, RahimObjective: The aim of the study was to assess the prevalence of mood and anxiety disorders among inpatients and the relationship between sociodemographic factors, medical illnesses and treatments. Methods: In the present study, we selected 650 inpatients from all clinics except psychiatry and pediatrics in a general hospital by a simple random sampling method. Based on the exclusion criteria, 57 patients were excluded. Mood and anxiety disorders were determined by means of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Results: Of the participants, 226 (37.5%) had a psychiatric disorder, 87 (14.4) had a mood disorder and 146 (24.2%) had an anxiety disorder. The most common specific diagnoses were not otherwise specified as anxiety disorder (9.5%), major depression (8.6%) and generalized anxiety disorder (7.6%). While the overall prevalence was highest in the hematology clinic (60.0%), it was lowest in the clinic of infectious diseases (22.7%). Logistic regression analysis indicated that the independent factors associated with psychiatric disorders were being of the female gender and a personal history of psychiatric disorders. Conclusions: In conclusion, results of the present study suggest that mood and anxiety disorders were frequently observed among inpatients, particularly in female patients and those with an individual history of psychiatric disorder. Successful treatment of these disorders may positively contribute to the course of the disease in inpatients. However, this assumption should be confirmed by further studies. (C) 2013 Elsevier Inc. All rights reserved.Öğe Mood, anxiety and personality disorders in patients with systemic lupus erythematosus(W B Saunders Co-Elsevier Inc, 2013) Uguz, Faruk; Kucuk, Adem; Cicek, Erdinc; Kayhan, Fatih; Tunc, RecepObjective: This study presents the current prevalence of mood, anxiety and personality disorders and factors associated with the existence of psychiatric disorders in patients with systemic lupus erythematosus (SLE). Methods: The study sample was comprised of 45 patients with SLE and 60 control subjects. Mood and anxiety disorders were ascertained by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition/Clinical Version. Personality disorders were diagnosed with the Structured Clinical Interview for DSM, Revised Third Edition Personality Disorders. The disease activity was assessed with SLE Disease Activity Index. Results: Of the 45 patients, 21(46.7%) had at least one mood or anxiety disorder, and 16 (35.6%) had at least one personality disorder. The most common Axis I and Axis II diagnoses in the patient group were major depression (22.2%) and obsessive compulsive personality disorder (20.0%), respectively. Specifically, major depression, generalized anxiety disorder and obsessive compulsive personality disorder were more prevalent in the SLE group compared to the control group. The existence of Axis I disorders was associated with a more severe disease activity of SLE. Conclusion: Mood and anxiety disorders, particularly major depression and generalized anxiety disorder, are frequently observed in patients with SLE. (C) 2013 Elsevier Inc. All rights reserved.Öğe Pregnancy-Onset Panic Disorder: Incidence, Comorbidity and Associated Factors(2015) Güler, Özkan; Kaya, Veli; Gezginç, Kazım; Kayhan, Fatih; Çiçek, Erdinç; Sönmez, Erdem ÖnderAmaç: Çalışmamızda öncelikle gebelik başlangıçlı panik bozukluğun insidans oranının saptanması amaçlanmış olup, ilave olarak bağımsız sosyo-demografik ve klinik risk faktörlerinin panik bozuklukla ilişkisinin olup olmadığı araştırılmıştır. Yöntem: Örneklem araştırma merkezi olan 2 obstetri polikliniğine ard arda gelen 1475 gebeden oluşmuş olup, bu 1475 gebeden gebelik baş- langıçlı panik bozukluk saptananlar (Grup 1, n20, %1,3) 1. grubu oluş- turmuştur. Kontrol grubu ise gebelik başlangıçlı depresyon ya da herhangi bir anksiyete bozukluğu olmayan 250 gebeden (Grup 2) oluşturulmuştur. Eksen I ve II tanıları yapılandırılmış klinik görüşme ölçekleri (Structured Clinical Interview for DSM-IV SCID ve Structured Clinical Interview for DSM-III-R Personality Disorders SCID II) kullanılarak saptanmıştır. Bulgular: Panik bozukluk için insidans %1,3 (n20) saptanmış olup, bu 20 kişiden 11'nin ilave anksiyete ya da duygudurum bozukluğuna sahip olduğu görülmektedir. Herhangi bir c kümesi kişilik bozukluğuna sahip olma oranı grup 1'de kontrollere göre anlamlı ölçüde yüksek saptanmıştır. Sonuç: Gebelik başlangıçlı panik bozukluğa sahip gebelerin kontrollere göre anlamlı derecede yüksek eksen II kişilik bozukluklarına ve gebelik öncesi anksiyete ve duygudurum bozukluklarına sahip olduğu anlaşılmıştırÖğe Quality of life in rheumatological patients: The impact of personality disorders(Sage Publications Inc, 2015) Uguz, Faruk; Kucuk, Adem; Cicek, Erdinc; Kayhan, Fatih; Salli, Ali; Guncu, Hatice; Cilli, Ali SavasObjectiveRheumatological diseases are associated with lower quality of life (QoL) levels. Psychiatric disturbances are frequently observed in these patients. This study examined the impact of personality disorders on the QoL of patients with rheumatological diseases. MethodThe study sample consisted of 142 participants including patients suffering from rheumatological disease with a personality disorder (n=30), without any personality disorder (n=112), and healthy control participants without physical or psychiatric disorders (n=60). The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I) and the Structured Clinical Interview for DSM, Revised Third Edition Personality Disorders (SCID-II) were used to determine Axis I and Axis II psychiatric disorders, respectively. QoL levels were assessed by means of the World Health Organization QoL Assessment-Brief. ResultsThe subscale scores of physical health, psychological health, and social relationships were significantly lower in patients with rheumatological disease regardless of the existence of personality disorder compared with the control participants. Rheumatological patients with a personality disorder had significantly lower subscale scores of psychological health (p=0.003) and social relationships (p<0.003) compared with patients without any personality disorder. ConclusionsPersonality disorders seem to be a relevant factor that maybe associated with QoL in patients suffering from rheumatological disease.Öğe Quality of life, family burden and associated factors in relatives with obsessive-compulsive disorder(Elsevier Science Inc, 2013) Cicek, Erdinc; Cicek, Ismet Esra; Kayhan, Fatih; Uguz, Faruk; Kaya, NazmiyeObjective: The aim of this study is to assess the quality of life (QoL), family burden and psychiatric disorders in first-degree relatives of patients with obsessive-compulsive disorder (OCD) and to compare them with healthy controls and their relatives. Methods: Forty patients with OCD and 47 of their first-degree relatives as well as 40 healthy subjects and 45 of their first-degree relatives were recruited in this study. OCD and comorbid anxiety or mood disorders were determined by means of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders. Comorbid Axis II disorders were diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition Personality Disorders. Type and severity of obsessive-compulsive symptoms were assessed with the Yale-Brown Obsessive-Compulsive Scale, and the disability of patients with OCD was evaluated with the WHO DAS II. Family burden and QoL in the relatives were evaluated with the Zarit Burden Interview (ZBI) protocol and the World Health Organization Quality of Life Assessment-Brief, respectively. Results: The mean ZBI score of family members of OCD patients was higher than the control relatives. Linear regression analysis indicated that the independent factors associated with ZBI were duration of OCD, comorbid major depressive disorder and poorer insight. Compared with those of control relatives, the QoL of relatives of patients with OCD was significantly lower in all domains. While the diagnosis of major depressive disorder in relatives of OCD patients was significantly higher than the control relatives, the diagnosis of any anxiety disorder did not differ. Conclusions: Our study provides evidence that OCD not only affects the lives of patients but also their family members. (C) 2013 Elsevier Inc. All rights reserved.Öğe The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: A prospective study(Pergamon-Elsevier Science Ltd, 2014) Cicek, Ismet Esra; Cicek, Erdinc; Kayhan, Fatih; Uguz, Faruk; Erayman, Ibrahim; Kurban, Sevil; Yerlikaya, F. HumeyraObjective: The aim of the study was to research the relationship between interferon (IFN) induced depression and sociodemographic characteristics, neurotrophic factors and oxidative stress. Methods: Sixty four cases, 34 with Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CNC), were included in the study. The patients were assessed with Structured Clinical Interview for DSM-IV (SCID-I), Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) at baseline on the 2nd and 6th weeks of treatment. S100 calcium binding protein B (S100B), brain-derived neurotrophic factor (BDNF), total antioxidant status (TAS) and total oxidative stress (TOS) levels were measured at the same visits. Results: In total, 20 patients were diagnosed with major depression (MD) on the sixth week. A significant relationship was found between depression developed after IFN therapy and baseline HARS scores and the type of IFN-alpha. When the pretreatment levels of HDRS, HARS, S100B, BDNF, TAS, and TOS were compared to those after treatment on the 2nd week, there was a significant increase in HDRS and HARS levels and a significant decrease in the levels of S1 00B and BDNF. No significant change was determined for TAS and TOS levels. Conclusions: Our study suggests that the pathogenesis of IFN induced depression may involve neurotrophic factors. (c) 2014 Elsevier Inc. All rights reserved.Öğe Sertraline-induced periorbital purpura: a case report(Sage Publications Ltd, 2015) Kayhan, Fatih; Eken, Zahide Eris; Uguz, FarukObjective: The incidence of mild to severe levels of spontaneous bleeding due to the usage of selective serotonin reuptake inhibitors (SSRIs) is relatively low. Although the exact mechanism is not known, it is thought that inhibition of the serotonin transporter together with a decrease in platelet serotonin could be responsible for the bleeding. Therefore, the use of SSRIs in conjunction with anti-aggregants may predispose to or exacerbate the risk of bleeding. In this case report, we describe a 44-year-old female patient with a diagnosis of anxiety disorder who spontaneously developed periorbital purpura during treatment with sertraline. Conclusion: Abnormal bleeding after treatment with an SSRI should be kept in mind, and alternative non-SSRI drugs of choice in such cases would be more appropriate. More extensive and comprehensive studies focusing on hemostasis and bleeding disorders are needed for SSRIs such as sertraline.
