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Öğe A case of nodular scabies with atypical course(Wiley, 2020) Daye, Munise; Temiz, Selami Aykut; Kilinc, Fahriye[Abstract Not Availabe]Öğe Effects of garlic oil (allium sativum) on acetic acid-induced colitis in rats: Garlic oil and experimental colitis(Turkish Assoc Trauma Emergency Surgery, 2020) Tanrikulu, Yusuf; Sen Tanrikulu, Ceren; Kilinc, Fahriye; Can, Murat; Kokturk, FuruzanBACKGROUND: Inflammatory bowel disease (IBD) is an important health problem. The most important hypotheses for the pathogenesis of this disease are the deterioration of immune responses and loss of tolerance against bacteria in the enteric flora. Although IBD has been widely investigated, its treatment remains difficult. This study aims to investigate the effects of garlic oil (GO) on an experimental colitis model. METHODS: Twenty-eight rats were randomly divided into four equal groups as follows: group 1 (sham), group 2 (control), group 3 (topical treatment) and group 4 (topical and systemic treatment). An acetic acid-induced colitis model was produced in groups 2, 3 and 4 and was administered normal saline, topical GO and topical and systemic GO, respectively. RESULTS: Hydroxyproline levels were lower in the treatment groups than in the control group. TNF-alpha levels were significantly lower in group 3 than in group 2. Macroscopic scores were significantly lower in group 4 than in group 2. Significant differences were observed between the treatment and control groups according to their epithelial loss. CONCLUSION: GO can reduce colonic damage and inflammation in the acetic acid-induced colitis model, with effects on both local and systemic treatments, but with a more pronounced effect in local treatment.Öğe Effects of garlic oil (allium sativum) on acetic acid-induced colitis in rats: Garlic oil and experimental colitis(Turkish Assoc Trauma Emergency Surgery, 2020) Tanrikulu, Yusuf; Sen Tanrikulu, Ceren; Kilinc, Fahriye; Can, Murat; Kokturk, FuruzanBACKGROUND: Inflammatory bowel disease (IBD) is an important health problem. The most important hypotheses for the pathogenesis of this disease are the deterioration of immune responses and loss of tolerance against bacteria in the enteric flora. Although IBD has been widely investigated, its treatment remains difficult. This study aims to investigate the effects of garlic oil (GO) on an experimental colitis model. METHODS: Twenty-eight rats were randomly divided into four equal groups as follows: group 1 (sham), group 2 (control), group 3 (topical treatment) and group 4 (topical and systemic treatment). An acetic acid-induced colitis model was produced in groups 2, 3 and 4 and was administered normal saline, topical GO and topical and systemic GO, respectively. RESULTS: Hydroxyproline levels were lower in the treatment groups than in the control group. TNF-alpha levels were significantly lower in group 3 than in group 2. Macroscopic scores were significantly lower in group 4 than in group 2. Significant differences were observed between the treatment and control groups according to their epithelial loss. CONCLUSION: GO can reduce colonic damage and inflammation in the acetic acid-induced colitis model, with effects on both local and systemic treatments, but with a more pronounced effect in local treatment.Öğe Histopathological Analysis in Testicular Tumors: 10 Years of Experience(Sage Publications Inc, 2023) Kilinc, Fahriye; Tas Aycicek, Seda; Esen, Haci HasanIntroduction. This study aims to review the morphological and immunohistochemical features of testicular tumors and compare them with prognostic parameters. Methods. Testicular tumors diagnosed between January 2011 and September 2021 were reviewed. Patient age, tumor subtype, size, spread, lateralization, number of foci, and immunohistochemical results were recorded. Results. A total of 121 tumors were detected, of which 108 (89%) were germ cell tumors (GCTs). Of the germ cell tumors, 70 (65%) were found to be pure type, and 38 (35%) were mixed germ cell tumors. The ratio of pure seminoma among GCTs was 56/108 (52%). Lymphatic/vascular invasion (LVI) was detected in 48/121 (40%), rete testis invasion in 32/121 (26%), hilar soft tissue invasion in 10/121 (8%), epididymal invasion in 5/121 (4%), and spermatic cord invasion in 5/121 (4%) patients. Lymphatic/vascular invasion was observed in 6 (22%) of 27 germ cell tumors smaller than 3 cm in size, and rete testis invasion was observed in 2 (7%), while in 40 (55%) of the 73 germ cell tumors of 3 cm and above, lymphatic/vascular invasion was seen, and 26 (36%) of them had rete testis invasion. Immunohistochemical results contributed significantly to the determination of tumor components and rates, especially in mixed germ cell tumors. Conclusion. Most of the tumors were germ cell tumors, and the majority were seminomas. Lymphatic/vascular invasion and rete testis invasion rates increase as the tumor diameter increases, which is more evident when the 3 cm cut-off value is taken into account (P < 0.005).Öğe Inflammatory myofibroblastic tumor of the lung: histopathology and imaging findings(Turkish Assoc Tuberculosis & Thorax, 2020) Poyraz, Necdet; Yazar, Mehmet Emin; Kilinc, Fahriye; Korkmaz, Celalettin; Altinok, TamerInflammatory myofibroblastic tumor is a neoplasia of unknown clinical etiology that clinically and radiologically tends to mimic a malignant neoplasm. The tumor is histologically composed of a mixture of inflammatory cells, myofibroblastic spindle cells and plasma cells. It can occur in any part of the body. Although pulmonary inflammatory myofibroblastic tumor is the most common primary lung mass especially in childhood, this entity is usually not considered in differential diagnosis of lung nodules or masses. In this article, we aimed to disscus the pathology and imaging findings of the pulmonary inflammatory myofibroblastic tumor and increase the familiarity of radiologists and clinicians to this entity.Öğe Irinotecan-induced NASH and liver failure(Elsevier Masson, Corp Off, 2021) Araz, Murat; Kilinc, Fahriye; Kerimoglu, Ulku; Keskin, Muharrem; Kucukkartallar, Tevfik[Abstract Not Availabe]Öğe Measurement of Epidermis, Dermis, and Total Skin Thicknesses from Six Different Body Regions with a new Ethical Histometric Technique(Wolters Kluwer Medknow Publications, 2018) Oltulu, Pembe; Ince, Bilsev; Kokbudak, Naile; Findik, Sidika; Kilinc, FahriyeIntroduction: Although it is important to know the normal values of dermis, epidermis, or total skin thicknesses (ST) for some drugs and vaccine research, skin-related clinical investigations, and skin transfer operations used in plastic surgery, it would not be ethical to take new biopsies from healthy volunteers to measure their ST. This study aims to describe a new ethical histometric technique for the measurement of skin layers and to determine the mean ST of some major body regions in the people living in our region. Materials and Methods: A total of 180 skin samples from six major body regions of 90 males and 90 females were enrolled in the study. The measurements were performed histometrically from appropriate skin samples obtained from the pathology archive. The samples were classified according to the six different parts of the body (scalp, abdomen, back, dorsum of foot, dorsum of hand, and the breast). Results: The mean epidermal thickness ranged from 76.9 +/- 26.2 to 267.4 +/- 120.6 mu m. The thickest epidermis was found in the dorsum of foot in women (267.4 +/- 120.6 mu m) while the thinnest was found in the breast in women (76.9 +/- 26.2 mu m). The mean dermal thickness ranged from 2115 +/- 946.4 to 5888 +/- 2422.3 mu m. The thickest dermis was found in the breast in men (5888 +/- 2422.3 mu m), while the thinnest dermis was found in the dorsum of hand in women (2115 +/- 946.4 mu m). Conclusions: Human ST varies according to ethnic origin. It was determined that the dermis and epidermis of Anatolian people are thicker than that of the previously reported other ethnic groups. The skin pathology archive can be used to create maps of the body's skin structure.Öğe Methylene blue ameliorates colonic injury in acetic acid-induced colitis model(Bayrakol Medical Publisher, 2022) Tanrikulu, Yusuf; Sen Tanrikulu, Ceren; Kilinc, Fahriye; Can, Murat; Kokturk, Furuzan; Kargin, Suleyman; Yilmaz, GokhanAim: Inflammatory bowel disease (IBD) is a serious health problem affecting the quality of life. IBDs caused by various pathophysiological mechanisms, including genetic, immunological, inflammatory, and environmental factors. Although it has been widely investigated, treatment of IBDs remains a difficult clinical problem. We aimed to investigate the healing of mucosal damage and anti-inflammatory effects of methylene blue (MB) in experimental colitis model. Material and Methods: Twenty-eight rats were randomly divided into four equal groups: group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical and systemic treatment). In groups 2, 3, and 4, acetic acid-induced colitis model was created. Normal saline to group 2, topical MB to group 3, and topical and systemic MB to group 4 were given. Results: The levels of hydroxyproline were lower in the treatment groups than in the control group (p=0.017 for group 3 and p=0.004 for group 4). There was no difference between groups according to the TNF- alpha levels. The results of macroscopic scores were significantly lower in treatment groups (group 3-4) than In the control group (group 2) (p=0.005 for group 3 and p=0.002 for group 4). There was a significant difference between the treatment groups and the control group according to the epithelial loss and inflammatory infiltrate (p=0.022 for group 3, p=0.026 for group 4 for both histopathological values). Discussion: MB ameliorates colonic injury in acetic acid-induced colitis model This effect of MB was observed both locally and with local + systemic administration.Öğe Molluscum contagiosum eruption in an adult patient using fingolimod and review of the literature(Galenos Publ House, 2023) Yildiz, Sibel; Temiz, Selami Aykut; Dursun, Recep; Uca, Ali Ulvi; Kilinc, FahriyeMolluscum contagiosum is a self-limiting viral eruption characterized by umbilical papules on the skin. Extensive, chronic, and larger lesions may occur in case of immunodeficiency. Fingolimod therapy used for the treatment of multiple sclerosis (MS) can also lead to immunosuppression and promote the development of molluscum contagiosum and other opportunistic infections. In this article, we discuss a case of extensive long-term molluscum contagiosum infection in the face of an adult patient treated for MS with fingolimod (after the discontinuation of which Molluscum contagiosum regressed), as well as similar cases from the literature.Öğe The ocular surface findings in alopecia areata patients: clinical parameters and impression cytology(Springer, 2022) Oltulu, Pembe; Oltulu, Refik; Turk, Huseyin Bugra; Turk, Nazli; Kilinc, Fahriye; Belviranli, Selman; Mirza, EnverPurpose The objective of this study was to examine the effects of alopecia areata (AA) on the ocular surface and conjunctival cytology. Methods A total of 48 subjects were included in the present study. Twenty-three subjects were assigned to group 1 as the patient group, and 25 healthy individuals were included in group 2 as the control group. The ocular surface examination was performed, and the right eyes of all participants were included in the analysis. Both groups underwent the following tests for evaluation of ocular surface: tear break-up time (TBUT), Schirmer I test, Ocular Surface Disease Index (OSDI), and conjunctival impression cytology (CIC). Results obtained from the tests were then analyzed and compared between the groups. Results The mean TBUT value was significantly lower in Group 1 compared to Group 2 (4.96 +/- 3.4 vs 10.52 +/- 4.8 s) (p < 0.001). There was no significant difference between Group 1 and Group 2 in terms of the mean Schirmer I test score (p = 0.129). The mean OSDI score was higher in Group 1 compared to Group 2 (15.48 +/- 10.4 vs 9.61 +/- 13.4), but the difference between both groups was not statistically significant (p = 0.1). The mean CIC score was statistically significantly higher in Group 1 than in Group 2 (1.65 +/- 0.7 vs 0.52 +/- 0.5) (p < 0.001). Conclusion The results of this study showed that AA was correlated with significant disturbances in conjunctival cytology and the tear function.Öğe Oral Rehabilitation of a Patient with Congenital Erythropoietic Porphyria: A Rare Case Report(Univ Indonesia, Fac Dentistry, 2020) Alan, Raif; Celebi, Hakki; Kilinc, Fahriye; Dursun, RecepCongenital erythropoietic porphyria (CEP) is an extremely rare disorder involved in chronic porphyrias. One of the recommended evaluations to determine disease severity and needs of a person with CEP is dental assessment. Objective: To present a case of CEP and its oral rehabilitation. Case Report: A 32-year-old female patient was admitted to the clinic with hyperkeratinization, skin fragility, fissures, and wounds in her perioral region and hands. Intraoral gingival bleeding, mucogingival stress, and missing teeth were recorded. After medical consultation, phase I and II periodontal therapies were performed. The patient expressed satisfaction of the results of the procedures in terms of the parameters evaluated. The rare occurrence of the disease may delay the diagnosis. An unmet need still exists for multidisciplinary orientation of patients with CEP. Conclusion: Dentists should have and follow guidelines for treating patients with CEP.Öğe Oral Rehabilitation of a Patient with Congenital Erythropoietic Porphyria: A Rare Case Report(Univ Indonesia, Fac Dentistry, 2020) Alan, Raif; Celebi, Hakki; Kilinc, Fahriye; Dursun, RecepCongenital erythropoietic porphyria (CEP) is an extremely rare disorder involved in chronic porphyrias. One of the recommended evaluations to determine disease severity and needs of a person with CEP is dental assessment. Objective: To present a case of CEP and its oral rehabilitation. Case Report: A 32-year-old female patient was admitted to the clinic with hyperkeratinization, skin fragility, fissures, and wounds in her perioral region and hands. Intraoral gingival bleeding, mucogingival stress, and missing teeth were recorded. After medical consultation, phase I and II periodontal therapies were performed. The patient expressed satisfaction of the results of the procedures in terms of the parameters evaluated. The rare occurrence of the disease may delay the diagnosis. An unmet need still exists for multidisciplinary orientation of patients with CEP. Conclusion: Dentists should have and follow guidelines for treating patients with CEP.Öğe Pigmented contact dermatitis development in a Sjogren's syndrome patient(Termedia Publishing House Ltd, 2021) Durmaz, Koray; Ataseven, Arzu; Ozer, Ilkay; Kilinc, Fahriye[Abstract Not Availabe]Öğe The prognostic role of HIF-1? and NF-?B expression in RAS wild-type metastatic colorectal cancer: A Turkish Oncology Group (TOG) study(Springer, 2023) Demirkiran, Aykut; Kilinc, Fahriye; Kocak, Mehmet Zahid; Demirkiran, Deniz; Korkmaz, Mustafa; Eryilmaz, Melek Karakurt; Araz, MuratBackground Not all RAS wild-type metastatic colorectal cancer (mCRC) patients experience the same benefit from anti-epidermal growth factor receptor (EGFR) treatments. Studies have shown that nuclear factor-kappa B (NF-kappa B), hypoxia-inducible factor-1 alpha (HIF-1 alpha), interleukin 8 (IL-8) and transforming growth factor beta (TGF-beta) may be therapeutic targets for mCRC. The aim of this study was to clarify the prognostic value of NF-kappa B, HIF-1 alpha, IL-8, and TGF-beta expression in patients with left-sided mCRC receiving EGFR inhibitors. Methods Patients with RAS wild-type, left-sided mCRC treated with anti-EGFR on the first line between September 2013 and April 2022 were included. Immunohistochemical staining for NF-kappa B, HIF-1 alpha, IL-8 and TGF-beta was performed from tumor tissues of 88 patients. Patients were divided into NF-kappa B, HIF-1 alpha, IL-8 and TGF-beta expression positive and negative group, moreover, expression positive group were also divided into two group as expression intensity low and high group. The median follow-up was 25.2 months. Results Median progression-free survival (PFS) was 8.1 (6-10.2) months in the cetuximab group, 11.3 (8.5-14) months in the panitumumab group (p = 0.09). Median overall survival (OS) was 23.9 (4.3-43.4) months in the cetuximab group, 26.9 (15.9-31.9) months in the panitumumab group (p = 0.8). Cytoplasmic NF-kappa B expression was present in all patients. The mOS was 19.8 (11-28.6) months in NF-kappa B expression intensity low group and 36.5 (20.1-52.8) months in high group (p = 0.03). The mOS of the HIF-1 alpha expression negative group was significantly longer compared with expression positive group (p = 0.014). There was no significant difference in IL-8 and TGF-beta expression status on mOS and mPFS (for all, p > 0.05). Positive expression of HIF-1 alpha was poor prognostic for mOS in the univariate analysis (HR:2.7, 95% CI 1.18-6.52, p = 0.02) and in multivariate analysis (HR 3.69, 95% CI 1.41-9.6, p = 0.008). High cytoplasmic expression intensity of NF-kappa B was found to have a good prognostic value for mOS (HR 0.47, 95% CI 0.26-0.85, p = 0.01). Conclusion High cytoplasmic expression intensity of NF-kappa B and negative expression of HIF-1 alpha could be a good prognostic marker for mOS in RAS wild-type left-sided mCRC.Öğe The protective and anti-inflammatory effect of methylene blue in corrosive esophageal burns: An experimental study(Turkish Assoc Trauma Emergency Surgery, 2019) Tannkulu, Ceren En; Tanrikulu, Yusuf; Kilinc, Fahriye; Bahadir, Burak; Can, Murat; Kokturk, Furuzan; Kefeli, AyseBACKGROUND: In developing countries, esophageal burns are quite common. They are caused by the ingestion of corrosive substances that may lead to esophageal perforation in the short-term and stricture formation in the long-term. Prevention of stricture progression in the esophagus is the main aim of the treatment for corrosive esophageal burns. We aimed to investigate the protective and anti-inflammatory effects of methylene blue (MB) treatment on corrosive esophageal burns. METHODS: Twenty-eight rats were used in the study and randomly divided into four equal groups; group 1 (Sham), group 2 (control), group 3 (topical treatment), and group 4 (topical plus systemic treatment). Except for group 1 (Sham group), all three groups received sodium hydroxide (NaOH) in order to generate esophageal burns. In addition, group 2 was given normal saline, group 3 topical MB, and group 4 topical and systemic MB. RESULTS: Hydroxyproline levels were found to be lower in each of the treatment groups as compared to the control group (p=0.005 for group 3 and p=0.009 for group 4). There were no differences in the tumor necrosis factor-alpha (TNF-alpha) levels between the groups. The stenosis index (SI) in the treatment groups was also lower than the control group (p=0.016 for group 3 and p=0.015 group 4). The histopathologic damage score (HDS) was prominently lower in group 4 as compared to the control group (p=0.05). CONCLUSION: MB is effective in treating tissue damage caused by corrosive esophageal burns and in preventing esophageal stenosis. Complication rates of corrosive esophageal burns may be decreased by using MB in the initial treatment stage.Öğe Pyruvate kinase M2 (PKM-2) expression and prognostic significance in glioblastoma patients(Springer, 2023) Yavuz, Berrin Benli; Kilinc, Fahriye; Kanyilmaz, Gul; Aktan, MeryemPurposePyruvate kinase M2 (PKM2) is a key enzyme that catalyzes the irreversible and final step of glycolysis. It is closely associated with cancer development and progression. The relationship between PKM2 and prognosis in glioblastoma (GB) patients is unknown. The aim of this study was to measure PKM2 expression and evaluate its effect on prognosis in GB patients.MethodsPatients who underwent radiotherapy (RT) for glioblastoma between 2010 and 2021 were evaluated immunohistochemically. A single pathologist evaluated pathology specimens of all patients. The intensity and extent of staining of tumor cells were scored. Patients were categorized as low and high PKM2.ResultsA total of 119 patients were evaluated. While 80.7% of the cases had a low score, 19.3% had a high PKM2 score. It was observed that the group with high PKM2 expression had lower performance, received more hypofractionated RT and received adjuvant chemotherapy (CT) less frequently. Median overall survival (OS) was 15.77 months in the low PKM2 expression group and 6.50 months in the high PKM2 group. In univariate analyses, PKM2 expression, age, performance status, type of surgery, RT scheme, and concurrent and adjuvant CT were prognostic factors in predicting OS. In multivariate analyses, PKM2 expression, type of surgery, RT scheme and receiving adjuvant CT were prognostic factors for OS.ConclusionPKM2 is an independent prognostic factor for survival and is associated with poor prognosis in GBM patients treated with radiotherapy. It may be a potential therapeutic target for anticancer therapy.Öğe Relationship between histomorphological findings and platelet activation in psoriasis(Wiley, 2022) Eren Karanis, Meryem Ilkay; Kucukosmanoglu, Ilknur; Oltulu, Pembe; Kilinc, Fahriye; Ozer, IlkayBackground Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity. Available studies examining the relationship between platelet activation markers and psoriasis have mostly focused on psoriasis area severity index. To the best of our knowledge, there is no study examining the relationship between histopathological features of a single psoriatic plaque and platelet activation. The present study examined the relationship between histomorphological findings obtained by morphometric analysis and psoriasis patients' PC, MPV, and PMI values. Materials and Methods Morphometric analysis was performed on hematoxylin and eosin-stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPETmin) and maximum epidermal thickness (ETmax), maximum suprapapillary keratosis thickness (SPKTmax), and maximum keratosis thickness (KTmax). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated. Results While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (p values = 0.015 and 0.005, r values = -0.238 and -0.271, respectively), no significant correlation was found between SPETmin and MPV (p value = 0.600, r value = -. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters. Conclusion We assume that an increased risk of platelet activation-related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.Öğe Secukinumab-induced Oral Lichen Planus: A Report of Case and Review of Literature(Istanbul Training & Research Hospital, 2021) Daye, Munise; Temiz, Selami Aykut; Gumus, Selim; Kilinc, FahriyeRecent years, we are witnessing a more frequent use of biological agent treatments. Secukinumab (SEC) has been used successfully in the management of psoriasis, psoriatic arthritis, and ankylosing spondylitis. However, the cases of SEC-related lichen planus (LP) are rarely encountered in the literature. Herein, this report presents a case of oral LP induced by SEC in a 33-year-old patient with psoriasis. In addition, this report aims to review the lichen reactions associated with SEC in the literature. In conclusion, LP cases attributable to SEC use are increasingly being observed in new reports. Clinicians who use SEC in their patients should be aware of this side effect and observe patients in terms of cutaneous-mucosal LP. With the introduction of new interleukin-17 (IL-17) inhibitors, the reporting of side effects is crucial for learning whether LP is class side effects or drug-specific side effects for clarifying pathogenesis. Dermatologists and rheumatologists should be aware of the very rare negative effect of IL-17 inhibitors.
