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    Synthesis and Antimicrobial Activity of Some 2-aminothiazole and 2-aminothiadiazine Derivatives
    (Wiley, 2018) Sariguney, Ahmet Burak; Kocabas, Erdal; Erci, Fatih; Torlak, Emrah; Coskun, Ahmet
    In this study, some thiazole and thiadiazine ring bearing compounds were synthesized, characterized by spectroscopic techniques, and evaluated as potential antimicrobial agents. Their antimicrobial activities evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. From these compounds, Compounds 2, 5, and 9 have been found to selectively inhibit Gram positives.
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    Synthesis, Antibacterial and Cytotoxic Activities of New Thiazole Based Pyrrolidine Derivatives
    (Biointerface Research Applied Chemistry, 2021) Kocabas, Erdal; Sariguney, Ahmet Burak; Erci, Fatih; Cakir-Koc, Rabia; Kocabas, Hilal Ozen; Torlak, Emrah; Coskun, Ahmet
    In this study, some thiazole-based pyrrolidine derivatives were synthesized, characterized by FT-IR and H-1 NMR spectroscopic techniques, and evaluated as potential antibacterial agents. Their antibacterial activities were evaluated by broth microdilution method and expressed as minimum inhibitory concentration; against Escherichia coli, Salmonella typhimurium, Bacillus cereus, and Staphylococcus aureus. Cytotoxicity studies of synthesized compounds were also conducted to minimize the toxic effects on healthy mammalian cells. From synthesized compounds, 4-F-phenyl derivative compound (11) has been found to inhibit Gram-positive bacteria with minimum toxicity selectively.