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Öğe The Evaluation of the Prevalence of Metabolic Syndrome and Lipid Profile According to Body Mass Index in Obese Women(Duzce Univ, 2015) Korkut, Yasemin; Kocak, Fatma Emel; Kilit, Turkan Pasali; Arikan, Inci; Teksen, Yasemin; Yontem, Mustafa; Birgul, MehmetObjective: We aimed to evaluate the prevalence of metabolic syndrome (MS) and lipid profile according to body mass index (BMI) in obese women. Methods: BMI and blood parameters were compared in 102 patients who applied to the clinic owing to the failure to lose weight complaint between December 2013 and January 2014. They were classified according to BMI; 30,0-34,9 kg/m(2) as 1st degree obese, 35,0-39,9 kg/m(2) as 2nd degree obese, and >= 40,0 kg/m(2) as 3rd degree (morbid) obese. Results: All the patients were women. Their age average was 45,01 +/- 11,0 yrs. 36,3% of these patients were at 1.st degree, 5% of them were at 2.st degree and 39,2% of them were at 3.st degree of obesity. We found the prevalence of MS as 56,9%. According to their degree of obesity increased prevalence of MS, the MS was increased with increasing age (p<0,05). With the evaluation of patients blood parameters according to obesity degrees we found a meaningful increase in blood glucose levels avarage (p=0,048), HOMA-IR (p=0,009) and in insulin levels (p=0,031) in upper levels of obesity. Whereas, while the obesity degrees were increasing there were in increase in triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and HbA1c levels but the rise was statically meaningless. Conclusion: In present study we found that as BMI was increasing the MS was increasing also. Although we didn't find a significant relationship between BMI increment and lipid profile in the women with MS but there was a direct proportion. Besides we found that as the BMI was increasing, blood glucose, HOMA-IR, insulin levels were increasing also. As a conclusion if the women and their family change their eating habits and life styles, the whole family will be affected positively and it is clear that the development of obesity, dsylipidemia and MS will decrease.Öğe SERUM LEVELS OF OXIDATIVE STRESS MARKERS IN SUBCLINICAL AND OVERT HYPOTHYROIDISM VERSUS CONTROL GROUP IN POPULATION OF KUTAHYA CITY, TURKEY(Gomal Medical Coll, 2021) Yontem, Mustafa; Arslan, Serap; Erdogdu, Behic Selman; Kocak, Fatma EmelBackground: Overproduction of oxygen-related free radicals and inadequate antioxidant defense are critical in hypothyroidism, as they might lead to future life-threatening diseases. The objectives of this study were to compare serum levels of oxidative stress markers; total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), paraoxonase-1 (PON-1), and arylesterase (ARYL) in patients with subclinical hypothyroidism (SH) and overt hypothyroidism (OH) versus healthy controls in population of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey, from July to December, 2016. Three study groups of 45 each were formed as healthy controls, patients with SH and OH. Serum levels of TOS, TAS, OSI, PON-1, and ARYL were five research variables with ratio scale, but skewed, so described by median and IQR with 95% Cl. Kruskal-Wallis and multiple comparison tests were used for hypotheses testing. Results: Serum levels of TOS and OSI were higher in SH group (p-values 0.032; <.0001; respectively) and OH group (p-values <.0001; <.0001, respectively) than healthy controls, while serum levels of TAS, PON-1 and ARYL were lower in SH group (p-values <.0001; <.0001; <.0001, respectively) and OH group (p-values <.0001; <.0001; <.0001, respectively) than control group. Conclusion: Our study showed that serum levels of TOS and OSI were higher in subclinical and overt hypothyroidism than in healthy controls; while serum levels of TAS, PON-1, and ARYL were lower in subclinical and overt hypothyroidism than in healthy controls.Öğe SERUM LEVELS OF OXIDATIVE STRESS PARAMETERS IN POSTMENOPAUSAL VERSUS FERTILE WOMEN OF KUTAHYA CITY, TURKEY(Gomal Medical Coll, 2021) Erdogdu, Behic Selman; Yontem, Mustafa; Kocak, Fatma Emel; Yazar, HayrullahBackground: Decreased concentration of both oestrogen hormone and vitamin D in postmenopausal period may lead to oxidative stress, lipid peroxidation, dyslipidaemia, osteoporosis, and cardiovascular diseases. The objectives of this study were to determine and compare the serum levels of oxidative stress parameters; TOS, TAS, OSI, PON-1, ARYL in postmenopausal and fertile women of Kutahya city, Turkey. Materials & Methods: This cross-sectional study was conducted at Department of Biochemistry, Faculty of Medicine, Kutahya University of Health Sciences, Kutahya, Turkey from July, 2016 to December, 2016. Kutahya is a city in western Turkey, with population of 237,804 as per 2011 estimates. Two samples were drawn from this population with consecutive technique. Study group included 40 menopausal women, while control group included 40 healthy fertile women. After overnight fasting, venous blood samples were collected, centrifuged, aliquoted into a polystyrene tube, and aliquots were stored at -80 degrees C until measurement for total oxidant status (TOS), total antioxidant status (TAS), paraoxonase-1 (PON-1), and arylesterase (ARYL) measurements were made. Levels of TOS, TAS, OSI, PON-1, ARYL were five research variables on ratio scale. `Normal' data were described by mean, range and SD and skewed data by median, Q1, Q3 and IQR with 95% confidence intervals. For normal data, independent-samples t-test and for skewed data Mann-Whitney U test was used for hypotheses testing. Results: Serum total oxidant status (TOS) and oxidative stress index (OSI) levels were significantly higher (p-value.015 &.003 respectively), and serum paraoxonase-1 (PON-1) and arylesterase (ARYL) levels were significantly lower in postmenopausal than fertile women (p-value <.0001 &.0005 respectively), with no statistical difference for serum total antioxidant status (TAS) levels between the two groups (p-value.186). Conclusion: Postmenopausal period is associated with oxidative stress and decreased antioxidant defence. HDL-c-dependent PON-1 and ARYL activities are also reducing due to a decrease of HDL-c with menopause. Elevated levels of TOS and OSI, decreased levels of PON-1 and ARYL may lead to various life-threatening diseases such as cardiovascular disorders or cancer.